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Recent gene knockout studies on mice have shown the role of toll-like receptor 9 (TLR9) in resolution of venous thromboembolism (VTE) through sterile inflammation. However, the role of a putative functional TLR9 polymorphism (rs5743836) in risk assessment of VTE recurrence remains unknown. The aim of our study was to investigate the TLR9 rs5743836 polymorphism in VTE patients and its association w
Objective. To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients
Fontan palliation patients are at risk for ventricular arrhythmias post-operatively. This study aimed to evaluate whether differences in the spatial QRS-T angle can reliably predict ventricular arrhythmias in patients who had undergone Fontan palliation. A total of 117 patients who had the Fontan palliation and post-Fontan catheterization were included. Ventricular arrhythmias were identified in n
Background: Several interventions have been carried out to tackle health inequalities between migrant groups, especially refugees, and native-born European populations. These initiatives are often address language or cultural barriers. One of them is the International Health Advisors (IHA) in Sweden; a peer education intervention aimed at providing health information for recently settled migrants.
Objective: Healthcare professionals (HCPs) are required to assess and train patients in the correct use of inhalers but are often unable to demonstrate correct technique themselves. We sought to assess the level of training required for HCPs to master and maintain device mastery when using two different dry powder inhalers (DPIs). Methods: We conducted a randomized, un-blinded, crossover study in
Moving from the analysis of some Italian case law the article point out which are the limits of the employer’s power to control the workers with remote instruments following the Italian law, with specific attention on the notion of “remote control instrument” in the context of the contemporary digital society.
Lung Clearance Index (LCI) provides an overall measurement of ventilation inhomogeneity. This population-based study examines whether LCI predicts pulmonary obstruction and incidence of chronic obstructive pulmonary disease (COPD) events over a long-term follow-up. Multiple breath nitrogen washout and spirometry were performed in 674 men from the cohort “Men born in 1914” at age 55 years. Subjects
Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization, cytokine gene expression, T cell survival, proliferation, and differentiation. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are the main enzymes involved in PIP2 biosynthesis by phosphorylating phosphatidylinositol 4-monophosphate (PI4
Background: To determine the feasibility and efficacy of a retinal telephotocoagulation treatment plan for diabetic macular edema. Methods: Prospective, interventional cohort study at two clinical sites. Sixteen eyes of ten subjects with diabetic macular edema underwent navigated focal laser photocoagulation using a novel teleretinal treatment plan. Clinic 1 (King Khaled Eye Specialist Hospital, R
Moving from some Italian case law the article analyses several aspect linked to the transfers of undertaking such as its legal notion (and its differences between the transfers of a plurality of goods), the right to raise a legal claim following the Italian civil procedure and the consequences of the violation of the information duty of the trade unions.
DEBATT - av STEFAN LARSSON, docent och föreståndare, Lunds universitets internetinstitut (LUii) och forskare vid tankesmedjan Fores samt JONAS LEDENDAL, jur.dr. i handelsrätt och forskare vid Institutionen för handelsrätt, Ekonomihögskolan, Lunds universitet. Forskarna skriver i Dagens Juridik om personuppgifter som en konsumentfråga, dvs till skillnad från att bara förstå och reglera data utifrån
Precipitation can be quantified using a rain gauge network, or a remotely sensed precipitation product. Ultimately, the choice of dataset depends on the particular application, the catchment size, climate and the time period of study. In a region with a long record and a dense rain gauge network, the elevation-modified ground-based precipitation product, PRISM, has been found to work well. However
Background Human epidermal growth factors 2 and 3 (HER2 and HER3) are members of the EGFR family that drives oncogenesis mainly through activation of the RAS-RAF-MEK-ERK pathway. While the prognostic value of HER2 and HER3 alterations in colorectal cancer (CRC) remains uncertain, KRAS and BRAF mutations confer resistance to targeted therapies and poor prognosis. Sidedness of the primary tumour has
Malaria is a disease spread by mosquitoes, and it is a major global cause of morbidity and mortality. Most of the deaths in malaria are caused by the Apicomplexan parasite Plasmodium falciparum. Immunity against the disease is dependent on repeated exposure, and it usually takes several years to develop. Antibodies against different antigens are an important part of immunity, but cellular immunity
Flame stabilized by a bluff-body is a common scene in many engineering applications due to the enhanced mixing characteristics, improved flame stability, and ease of combustion control. We recently designed a burner which has a conical bluff body with a central air injector. In the current work, effects of the central air jet on the heat load of the bluff body, the flame structures and the flame b
Throughout history, Jewish notions of justice, hope and redemption have inspired political visions within as well as beyond the Jewish tradition. In the past century, examples can be drawn from Ernst Bloch to Walter Benjamin and Jacques Derrida. Also in the present politico-philosophical debate, a number of prominent voices draw explicitly on Jewish sources in their attempts to formulate radical v
This paper presents the mathematical conditions and the associated design methodology of an active fault diagnosis technique for continuous-time linear systems. Given a set of faults known a priori, the system is modeled by a finite family of linear time-invariant systems, accounting for one healthy and several faulty configurations. By assuming bounded disturbances and using a residual generator,
We consider flow-inducing networks, a class of models that are well-suited to describe important biochemical systems, including the MAPK pathway and the interactions at the trans-Golgi network. A flow-inducing network is given by the interconnection of subsystems (modules), each associated with a stochastic state matrix whose entries depend on the state variables of other modules. This results in
Slotted wing tips of birds are commonly considered an adaptation to improve soaring performance, despite their presence in species that neither soar nor glide. We used particle image velocimetry to measure the airflow around the slotted wing tip of a jackdaw (Corvus monedula) as well as in its wake during unrestrained flight in a wind tunnel. The separated primary feathers produce individual wakes
