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Objective: To investigate the expression and clinical significance of DNA helicase RecQL1 in cervical carcinoma and cervical intraepithelial neoplasia(CIN). Methods: The expression of DNA helicase RecQL1 were determined with reference to clinicopathological features and patient survival. 75 cervical carcinoma, 60 CIN and 20 normal control cases were collected for immunohistochemical analysis. Resu
Objective: To investigate the expression of Pyruvate dehydrogenase kinase 1(PDK1), phosphorylated Pyruvate dehydrogenase (p-PDH) and Pyruvate kinase isozyme type M2 (PKM2) based on Warburg effect pathway in cervical cancer tissues, and explore the roles of these molecules on prognosis and recurrence after postoperative radiation. Methods: The expressions of PDK1, p-PDH and PKM2 in primary tissues
Precisely determining the oxidation states of metal cations within variable-valence transition metal oxides remains a significant challenge, yet it is crucial for understanding and predicting the properties of these technologically important materials. Iron oxides, in particular, exhibit a remarkable diversity of electronic structures due to the variable valence states of iron (Fe 2+ and Fe 3+). A
During the last decade the intersection between social welfare research and the ecological crisishas been gaining increasing interest through discussions about sustainable welfare and eco-social policies. Less attention has been paid, however, to eco-social risks and to how climatechange “will impact the nature and distribution of social risks across di!erent parts of thepopulation” (Hirvilammi et
Presentationen rör barn och ungas vardagliga geografier samt det sociala arbetets etablerade förhållningssätt till desamma. Särskilt fokus kommer riktas mot hur erfarenhetsnära tolkningar av barn och ungas egna berättelser om ”den vanliga vardagen” kan utvidga det sociala arbetets förståelse för barn och ungas geografier, och hur dessa tolkningar kan be
Om assassinerna.
Hjärtat består av fyra hålrum; två kammare och två förmak, som separeras av fyra hjärtklaffar. Dessa säkerställer att blodet enbart flödar åt ett håll och ger därmed hjärtat förutsättningarna för effektiv pumpning av blodet. Mitralisklaffen är en av dessa fyra hjärtklaffar och separerar vänster förmak från vänster kammare, vilket gör att den utsätts för det högsta trycket i hjärtat. För att mitralThe heart consists of four chambers, two atria and two ventricles, separated by four valves that ensure unidirectional blood flow and efficient cardiac function. Among these, the mitral valve regulates blood flow between the left atrium and left ventricle and is one of the most mechanically loaded structures in the heart, stabilized by the chordae tendineae, which are connective structures. Conseq
The eighteenth century marks a watershed in European intellectual history. It witnessed the development of many civil rights ideas that were prerequisites for the emergence of modern political systems. One principle that appears to be supported by numerous empirical examples is that evolving political pluralism fostered the right to express one’s views with a certain degree of freedom. This articl
From the perspective of the Swedish education system, rural knowledge does not seem to be particularly important. Many young people in rural areas have deep and important knowledge that is invisible in school and during school time, both to teachers and to the young people themselves. This paper examines knowledge used in agriculture and animal husbandry, a type of knowledge that is particularly uFrom the perspective of the Swedish education system, rural knowledge does not seem to be particularly important. Many young people in rural areas have deep and important knowledge that is invisible in school and during school time, both to teachers and to the young people themselves. This paper examines knowledge used in agriculture and animal husbandry, a type of knowledge that is particular
This forum discusses and celebrates the career and impact of Jens Bartelson in and on Nordic academic International Relations. Through engagement with his central works and concepts, the contributions highlight the intellectual impact and development of Bartelson’s work over three decades.
Human dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in pyrimidine de novo synthesis and represents a promising target for cancer therapy. However, current inhibitors of DHODH have limited clinical effectiveness and adverse effects. Herein, we report NK-A 17E-233I, a novel small-molecule inhibitor of the human DHODH enzyme, identified through a prospective virtual screening metho
I denna artikel presenteras en närstudie av uppmaningar av typen Om ni är tysta, det vill säga om-inledda af-satser med uppmanande funktion. Syftet med studien är att undersöka funktionen hos uppmaningar som uttrycks med om-inledda af-satser i en idrottspedagogisk kontext. Materialet som ligger till grund för studien består av inspelningar från 26 idrottsaktivitetstillfällen. I detta material kan
The problem of reconstructing a spatial sound field from microphone signals and a coarse, partial, and/or uncertain point cloud representation of the boundaries of the room is considered. This problem has downstream applications within sound field control for which precise reconstruction is essential. Typical for these applications is that only microphone measurements are considered, resulting in
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are becoming an increasingly global concern. PFASs are highly fluorinated organic chemicals that represent a serious risk for environmental and human health. Due to their toxicological impact, PFASs are now included in several emission regulations. Even if the global level of PFASs use is decreasing much of present concentrations in the environ
PFAAs emission to the environment represents a potential risk to human health. Although, long-term global scale fate and transport models have been used to investigate potential trends in environmental levels, temporal trends and transports mechanisms of PFAAs are not fully understood. Due to high solubility in water, the behaviour of PFAAs in soil is important for environmental fate estimation an
The influence of three organic compounds and bakers' dry yeast on growth of external mycelium and phosphorus uptake of the arbuscular mycorrhizal fungus Glomus intraradices Schenck and Smith (BEG 87) was examined. Two experiments were carried out in compartmentalized growth systems with root-free sand or soil compartments. The sand and soil in the root-free compartments were left untreated or unif
Soil microbes drive ecosystem function and play a critical role in how ecosystems respond to global change. Research surrounding soil microbial communities has rapidly increased in recent decades, and substantial data relating to phospholipid fatty acids (PLFAs) and potential enzyme activity have been collected and analysed. However, studies have mostly been restricted to local and regional scales
Studies in temperate systems provide evidence that the abundance of arbuscular mycorrhizal fungal (AMF) depends on soil nutrient availability, which is mainly explained in the context of resource stoichiometry and differential plant biomass allocation. We applied this concept to an understudied ecosystem - tropical montane forest - analyzing root and AMF abundance along an elevational gradient wit
Deforestation and the use of fire to clear land have drastic effects on ecosystem functioning and compromise essential ecosystem services, especially in low-income tropical countries such as Madagascar. We evaluated the effects of local slash-and-burn practices on soil nutrients and arbuscular mycorrhizal (AM) fungi abundance in a southwestern Madagascar forest. Nine sampling plot pairs were estab
