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Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Both central and peripheral innate immune activation have been described as features of the disease. Isolated human HD monocytes have been shown to produce more cytokines upon LPS stimulation compared to control monocytes. Understanding alterations in the signalling c
Polyelectrolytes with amphiphilic counterions, PEACs, are water insoluble because the amphiphiles self-assemble into highly charged micelles that strongly associate with the equally highly charged polyions. However, in the presence of water soluble cyclodextrins (CDs) that form inclusion complexes with the amphiphiles and prevent micellization, PEACs become soluble as the dispersed amphiphiles beh
Obituary of Professor Lars Österlin (1923-2006)
In this article we consider how the operator of an electric power system should activate bids on the regulating power market in order to minimize the expected operation cost. Important characteristics of the problem are reaction times of actors on the regulating market and ramp-rates for production changes in power plants. Neglecting these will in general lead to major underestimation of the opera
Viral vector-mediated gene transfer is emerging as a novel therapeutic approach with clinical utility in treatment of Parkinson's disease. Recombinant adeno-associated viral (rAAV) vector in particular has been utilized for continuous l-3,4 dihydroxyphenylalanine (DOPA) delivery by expressing the tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) genes which are necessary and sufficient for
Addition of tri(2-furyl)phosphine. PFu(3), to [Os-3(CO)(10)(mu-H)(2)] at room temperature gives [HOs3(CO)(10)(PFu(3)) (mu-H)] (1), while in refluxing toluene the same reactants afford [Os-3(CO)(9)(mu(3)-PFu(2)(C4H2O))(mu-H)] (2) resulting from orthometallatation of a furyl ring. Reaction of PFu(3) with [Os-3(CO)(10-n)(NCMe)n] (n = 0, 1, 2) affords the substituted clusters [Os-3(CO)(12-n)(PFu(3))(n
This paper presents a complete characterization and solution to microphone position self-calibration problem for time-of-arrival (TOA) measurements. This is the problem of determining the positions of receivers and transmitters given all receiver-transmitter distances. Such calibration problems arise in application such as calibration of radio antenna networks, audio or ultra-sound arrays and WiFi
This paper analyzes the persistency in innovation behavior of firms. Using five waves of the Community Innovation Survey in Sweden, we have traced the innovative behavior of firms over a ten-year period, i.e., between 2002 and 2012. We distinguish between four types of innovations: process, product, marketing, and organizational innovations. First, using transition probability matrix, we found evi
Two fifths of the species in Ascomycota are lichen-forming, of which 10% and 3-4% have cyanobacteria as the primary and secondary photobionts respectively. To study the evolution of cyanobacterial symbioses, the phylogenetic relationships within the Ascomycota have been reconstructed. Phylogenetic analyses were made using direct optimization of nuclear SSU and LSU rDNA sequences under the parsimon
The utility analysis and integration model is a proposed business reference model that offers a structured framework to help utilities succeed on the enterprise level by facilitating the coordination and integration of people, process, and technology.
Background: The development of spasticity with age in children with cerebral palsy (CP) has, to our knowledge, not been studied before. In 1994, a register and a health care program for children with CP in southern Sweden were initiated. In the programme the child's muscle tone according to the modified Ashworth scale is measured twice a year until six years of age, then once a year. We have used
Critical review of Gunnar Granberg (ed.), "Kyrkan i Gamla Uppsala. Från katedral till församlingskyrka" (2014)
Abstract In recent years, more intensive chemotherapy regimens for mantle cell lymphoma (MCL) have been associated with prolongation of survival. In this study, our aim was to investigate prognostic factors and evaluate improvement in survival in MCL on a population level. The cohort included all patients diagnosed with MCL from 1 January 2000 to 31 March 2010 in the Swedish Lymphoma Registry. At
To study the causes of agricultural declines in south-west Sweden, a multi-proxy study including pollen analysis, bog surface wetness indicators and aeolian sediment influx reconstructions was carried out on the Store Mosse Bog, situated on the coastal plain of Halland. Patterns of agricultural changes during the past 6,000 years from this study were compared to one additional site on the coastal
The Struggle for a Women’s House. Ideological Dividing as Strategy or Remission?The Swedish shelter movement has on several occasions been disrupted due to bitter debates in the media. There appears to be a rift built in the movement. In this article I focus on the background to this by studying the formation of Stockholm’s first shelter for women in the late 1970s. In the struggle to get financiaThe Swedish shelter movement has on several occasions been disrupted due to bitter debates in the media. There appears to be a rift built in the movement. In this article I focus on the background to this by studying the formation of Stockholm's first shelter for women in the late 1970s. In the struggle to get financial support from the politicians it became clear that two different positions in t
We conducted an interlaboratory comparison between our radiocarbon-related research group at Lund University and the established ETH-Zurich facility to test the quality of the results obtained in Lund and to identify sources of potential background differences and scatter. We did find differences between the 2 laboratories in the contributions of chemical preparation, graphitization, and measureme
Introduction: The fight against maternal deaths has gained attention as the target date for Millennium Development Goal 5 approaches. Induced-abortion is one of the leading causes of maternal deaths in developing countries which hamper this effort. In Ghana, alcohol consumption and unwanted pregnancies are on the ascendancy. We examined the association between alcohol consumption and maternal mort
Photoreceptor cell death is the major hallmark of a group of human inherited retinal degenerations commonly referred to as retinitis pigmentosa (RP). Although the causative genetic mutations are often known, the mechanisms leading to photoreceptor degeneration remain poorly defined. Previous research work has focused on apoptosis, but recent evidence suggests that photoreceptor cell death may resu
