BACKGROUND: For muscle-invasive bladder cancer (MIBC), no tissue biomarkers are available for clinical use to predict response to neoadjuvant chemotherapy.OBJECTIVE: To investigate how molecular subtypes impact pathological response and survival in patients receiving preoperative cisplatin-based chemotherapy.DESIGN, SETTING, AND PARTICIPANTS: Classification of a retrospective cohort of 149 patient

A compact soft X-ray emission spectrometer for the energy region of 50-600 eV has been designed and constructed for the long undulator beamline BL-09A in the NewSUBARU synchrotron radiation (SR) facility. The optical design of the spectrometer is based on a grazing incidence flat-field spectrometer using a valid line-spacing grating. The average groove density of the grating is 2000 L/mm, and the

A study of the excitation energy dependence of resonant X-ray emission spectra across the O1s absorption edge in combination with X-ray absorption spectroscopy and density functional theory reveals the site-specific valence electronic structure of liquid acetic acid under ambient conditions.

During atrial fibrillation (AF), the heart relies heavily on the atrio-ventricular (AV) node to regulate the heart rate. Thus, characterization of AV-nodal properties may provide valuable information for patient monitoring and prediction of rate control drug effects. In this work we present a network model consisting of the AV node, the bundle of His, and the Purkinje fibers, together with an asso

Derivatives of 3-ethyl-3-(hydroxymethyl)oxetane (trimethylolpropane oxetane), potentially useful in cationic UV-curable formulations, were prepared by the simple acid-catalyzed addition of alcohols to 1-alkenyl ethers. Examples include several difunctional oxetane derivatives along with one fluorinated and one acryloylated oxetane derivative. These new materials may find use as reactive diluents o

The cationic photopolymerization of trimethylolpropane tripropenyl ether (TPE), initiated by a diaryl iodonium salt, has been investigated. The influence of the presence of different alcoholic additives on the rates of photopolymerization and on the properties of the networks obtained has been studied. New 1-propenyl ethers (trimethylolpropane dipropenyl ether (DPE) and its acetyl ester) were synt

A kinetic investigation of the photoinitiated cationic copolymerization of 1-propenyl ethers with vinyl ethers monomers was performed by using FT-IR and 1H-NMR analysis. FT-IR results, obtained in bulk, indicate a higher reactivity of the vinyl ether with respect to the 1-propenyl ether double bond. 1H-NMR analysis, in CDCl3 solution, confirms these results which agree with the literature data con

Thiol-ene photocurable systems based on a trifunctional thiol [trimethylolpropane tris-(3-mercaptopropanoate)] and two different multifunctional allyl ethers (trimethylolpropane triallyl ether and Boltorn U2, an allyl functional dendritic polyester) were examined. To these systems, small amounts (

Despite profound progress made in reducing neonatal mortality, it remains one of the major global health challenges. In 2019, the World Health Organization estimated that 2.4 million neonatal deaths occurred, accounting for over 45 percent of under-5 deaths worldwide. Most of these neonatal mortalities occur in low-and middle-income (LMIC) with East African countries of Kenya, Uganda and Tanzania

Characteristics of polyol mercaptoalkanoates, polyol allyl ethers and coatings produced thereof are reported. The viscosities of examined thiols are in the range of 110-410 mPas (23 °C) and the density of functional groups 4-8 mmol/g. The corresponding data for the studied polyol allyl ethers are 3-240 mPas (23 °C) and 7.5-13.3 mmol/g, respectively. Formulations of these components were made and p

Alla svenska lärare har enligt skollagen ett dubbelt uppdrag, kunskapsuppdraget och demokratiuppdraget. Demokratiuppdraget uppfattas som problematiskt av utvärderande myndigheter, lärare och skolans huvudmän. Alla gymnasielärare i svenska ska enligt senaste läroplanen GY11 explicit arbete med retorik. Finns det retoriska övningar som kan integrera såväl litteratur- och språkundervisning med demokr

We analyzed the impacts of drought severity on a variety of sectors in a topographically complex basin (the upper Aragón basin 2181 km2) in the Central Spanish Pyrenees. Using diverse data sources including meteorological and hydrological observations, remote sensing and tree rings, we analyze the possible hydrological implications of drought occurrence and severity on water availability in variou

Background Mycobacterium tuberculosis (TB) is the deadliest disease that claims millions of deaths globally. Ethiopia is among the countries heavily hit by the disaster. Despite the effective directly observed treatment and TB infection control (TBIC) measures provided by the world health organization (WHO), the rate of new cases increased daily throughout the country. Healthcare workers (HCWs) ar

The climate-vegetation coupling exerts a strong control on terrestrial carbon budgets and will affect the future evolution of global climate under continued anthropogenic forcing. Nonetheless, the effects of climatic conditions on such coupling at specific times in the growing season remain poorly understood. We quantify the climate-vegetation coupling in Europe over 1982–2014 at multiple spatial

Background: Integrated community case management (CCM) has led to reductions in child mortality in Malawi resulting from illnesses such as malaria, pneumonia, and diarrhea. However, adherence to CCM guidelines is often poor, potentially leading to inappropriate clinical decisions and poor outcomes. We determined the impact of an e-CCM app on the referral, reconsultation, and hospitalization rates

MOTIVATION: Gene expression-based multiclass prediction, such as tumor subtyping, is a non-trivial bioinformatic problem. Most classifier methods operate by comparing expression levels relative to other samples. Methods that base predictions on the expression pattern within a sample have been proposed as an alternative. As these methods are invariant to the cohort composition and can be applied to

A search for new phenomena is presented in final states with two leptons and one or no b-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full run-2 proton-proton collision dataset recorded at a center-of-mass energy of s=13 TeV by the ATLAS experiment at the LHC, corres

PD-L1 expression assessed by immunohistochemical staining is used for the selection of immunotherapy in non-small cell lung cancer (NSCLC). Appropriate validation of PD-L1 expression in cytology specimens is important as cytology is often the only diagnostic material in NSCLC. In a previous study comprising two different cohorts of paired biopsies and cytological specimens, we found a fairly good