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Epidemiological evaluation of cytogenetic biomarkers as potential surrogate end-points for cancer

Various occupational exposures have been monitored by chromosomal aberrations, sister chromatid exchanges and micronuclei in peripheral blood lymphocytes. During the last decade, epidemiological studies have evaluated whether any of these markers foreshadows cancer risk. Results from Nordic, Italian and Czech cohorts support an approximately twofold cancer risk among subjects with high frequencies

Primary production in two shallow lakes with contrasting plant form dominance: A paradox of enrichment?

We estimated total lake plant biomass and primary net production in two shallow Swedish lakes that differ in nutrient loading and plant form dominance. In clearwater Lake Krankesjon (10 mu g chlorophyll a L-1), submerged macrophytes contributed more than phytoplankton and epiphyton to the estimated plant biomass. Estimated net primary production during May to September was 90-130, 1.2, and 14 g C

Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women

The relationships between abdominal and pelvic fat compartments and glucose and lipid metabolism were investigated in early postmenopausal women. Fifty-five healthy, postmenopausal women aged 52-53 yr participated in the study. Fat distribution (intra-abdominal and sc abdominal fat, and intrapelvic and sc pelvic fat) was estimated by computed tomography. Insulin sensitivity was assessed by euglyce

Appropriating civic information and communication technology: a critical study of Swedish ICT policy visions

With 71 percent of its households owning computers and having internet access, Sweden is one of the world's leading information and communication technology (ICT) nations. The prevalence of ICT has inspired the Swedish government to ascribe it as a civic tool, capable of cultivating more active citizenship and a stronger democracy. However, despite its lofty intentions, Sweden's ICT policy has a s

Dopamine dysregulation of movement control in l-DOPA-induced dyskinesia.

The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by l-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that th

A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans

Respiratory tract deposition data of ultrafine aerosol particles, hygroscopic particles and ambient particles in general are scarce. Measurements are associated with several difficulties. The objective of this work was to design a method for fast determination of highly size-resolved fine and ultrafine particle deposition, to be used on larger groups of human subjects in exposure studies and in ty

The trajectories of particles in Stokes waves

Analyzing a free boundary problem for harmonic functions we show that there are no closed particle paths in an irrotational inviscid traveling wave propagating at the surface of water over a flat bed: within a period each particle experiences a backward-forward motion with a slight forward drift.

Approximation algorithms for time-dependent orienteering

The time-dependent orienteering problem is dual to the time-dependent traveling salesman problem. It consists of visiting a maximum number of sites within a given deadline. The traveling time between two sites is in general dependent on the starting time. For ε greater than or equal 0, we provide a (2+ ε)-approximation algorithm for the time-dependent orienteering problem which runs in polynomial

Determination of stellar ages from isochrones: Bayesian estimation versus isochrone fitting

We present a new method, using Bayesian estimation, to determine stellar ages and their uncertainties from observational data and theoretical isochrones. The result for an individual star is obtained as the relative posterior probability density as function of the age ("G function"). From this can be derived the most probable age and confidence intervals. The convoluted morphology of isochrones an

Response of zooplankton to nutrient enrichment and fish in shallow lakes: a pan-European mesocosm experiment

1. Responses of zooplankton to nutrient enrichment and fish predation were studied in 1998 and 1999 by carrying out parallel mesocosm experiments in six lakes across Europe. 2. Zooplankton community structure, biomass and responses to nutrient and fish manipulation showed geographical and year-to-year differences. Fish had a greater influence than nutrients in regulating zooplankton biomass and es

Size Matters More Than Chemistry for Cloud-Nucleating Ability of Aerosol Particles

Size-resolved cloud condensation nuclei (CCN) spectra measured for various aerosol types at a non-urban site in Germany showed that CCN concentrations are mainly determined by the aerosol number size distribution. Distinct variations of CCN activation with particle chemical composition were observed but played a secondary role. When the temporal variation of chemical effects on CCN activation is n

Algorithm and implementation of the K-best sphere decoding for MIMO detection

K-best Schnorr-Euchner (KSE) decoding algorithm is proposed in this paper to approach near-maximum-likelihood (ML) performance for multiple-input-multiple-output (MIMO) detection. As a low complexity MIMO decoding algorithm, the KSE is shown to be suitable for very large scale integration (VLSI) implementations and be capable or supporting soft outputs. Modified KSE (MKSE) decoding algorithm is fu

Parameter estimation of beta distribution for unit hydrograph derivation

Traditionally used methods for developing a synthetic unit hydrograph (SUH) are well known for their limitations. In last few decades, use of probability distribution functions in developing SUHs has received much attention. In this study, the potentials of a three-parameter beta distribution are explored. Using a analogy between the three-parameter beta-distribution shape and the SUH shape, appro

Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis

The water channel aquaporin-1 (AQP1) is considered as the molecular counterpart of the ultrasmall pore predicted by the three-pore model of fluid transport across the peritoneal membrane. However, the definitive proof of the implication of AQP1 in solute-free water transport, sodium sieving, and ultrafiltration (UF) during peritoneal dialysis (PD) is lacking, and the effects of its deletion on the

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes.

OBJECTIVE: Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the drawback of the short half-life of GLP-1, inhibitors of the GLP-1-degrading enzyme dipeptidyl peptidase IV (DPP IV) have been examined. Such inhibitors improve glucose tolerance in insulin-resistant rats and mice. In this study, we examined the 4-week effect of 1-[[[2-[(5