Osteopontin (OPN) is involved in various physiological processes and also implicated in multiple pathological states. It has been suggested that OPN may have a role in type 2 diabetes (T2D) by protecting pancreatic islets and interaction with incretins. However, the regulation and function of OPN in islets, especially in humans, remains largely unexplored. In this study, we performed our investiga

This paper contributes to the literature on internal migration by estimating parameters for push and pull factors by modelling the complete migration decision. Using data based on individuals linked between the complete Swedish censuses of 1880 and 1890, we consider both the push factors which determined whether an individual choose to leave their origin and the pulls factors which attracted migra

Chemical hypersensitivity is an immunological response towards foreign substances, commonly referred to as sensitizers, which gives rise primarily to the clinical symptoms known as allergic contact dermatitis. For the purpose of mitigating risks associated with consumer products, chemicals are screened for sensitizing effects. Historically, such predictive screenings have been performed using anim

The effects of fuel properties on the performance and emissions of an engine running in partially premixed combustion mode were investigated using nine test fuels developed in the gasoline boiling point range. The fuels covered a broad range of ignition quality and fuel chemistry.The fuels were characterized by performing a load sweep between 1 and 12 bar gross IMEP at 1000 and 1300 rpm. A heavy d

Contact allergy induced by certain chemicals is a common health concern, and several alternative methods have been developed to fulfill the requirements of European legislation with regard to hazard assessment of potential skin sensitizers. However, validated methods, which provide information about the potency of skin sensitizers, are still lacking. The cell-based assay Genomic Allergen Rapid Det

With the shift of focus of the regulatory bodies, from fixed process conditions towards flexible ones based on process understanding, model-based optimization is becoming an important tool for process development within the biopharmaceutical industry. In this paper, a multi-objective optimization study of separation of three insulin variants by reversed-phase chromatography (RPC) is presented. The

The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in

An experimental analysis of the fire behavior of stone wool composites with stainless steel and gypsum plasterboard linings was performed. The focus was to characterize the micro-scale behavior of stone wool, and identify the main processes occurring in stone wool composites when exposed to heat. Thermogravimetric analysis was applied to two different wools with varying densities and binder conten

Combination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burnCombination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burn

Endothelial progenitor cells (EPCs) contribute to neovasculogenesis and reendothelialization of damaged blood vessels to maintain the endothelium. Dysfunction of EPCs is implicated in the pathogenesis of vascular injury induced by homocysteine (Hcy). We aimed to investigate the role of Cyclin A in Hcy-induced EPCs dysfunction and explore its molecular mechanism. In this study, by treatment of EPCs

Assessment of neurologic prognosis after cardiac arrest. Updated recommendations from the Swedish CPR Council Expert Group European Resuscitation Council (ERC) issued updated guidelines for postresuscitation care in 2015. This paper provides updated Swedish recommendations for neurological prognostication of patients remaining unconscious after cardiac arrest (CA). The prognostication should be ba