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Antigen-binding sites dominate the surface properties of antibodies

We have found a remarkable relationship between the specificity of antibodies and their chromatographic behavious upon liquid-liquid partition chromatography (LLPC). Well characterized human and murine monoclonal antibodies and Fab/Fv fragments thereof as well as mouse/human chimeric antibodies were employed. While, lgG 1, 2 and 4 antibodies with identical specificities (affinity constants) have i

Biological treatment of industrial wastes in a photobioreactor

An algal-bacterial consortium was tested for the treatment from a coke factory. A Chlorella vulgaris strain and a phenol-degrading Alcaligenes sp. were first isolated from the wastewater treatment plant to serve as inocula in the subsequent biodegradation tests. Batch tests were then conducted with samples from the real wastewater or using a synthetic wastewater containing 325 mg phenol/l and 500

A circumferentially flanged tibial tray minimizes bone-tray shear micromotion.

Aseptic loosening of the tibial component is the major complication of total knee arthroplasty There is an association between early excessive shear micromotion between the bone and the tray of the tibial component and late aseptic loosening. Using non-linear finite element analysis, whether a tibial tray with a circumferentially flanged rim and a mating cut in the proximal tibia could minimize bo

First measurement of charged current cross sections at HERA with longitudinally polarised positrons

Data taken with positrons of different longitudinal polarisation states in collision with unpolarised protons at HERA are used to measure the total cross sections of the charged current process, e(+) p -> nu X, for negative four-momentum transfer squared Q(2) > 400 GeV2 and inelasticity gamma < 0.9. Together with the corresponding cross section obtained from the previously published unpolarised da

Characterization of normal and polycystic ovaries using three-dimensional power Doppler ultrasonography

Purpose: To evaluate the characteristics of polycystic compared to normal ovaries using three-dimensional (3-D) power Doppler ultrasonography. Methods: We recruited 42 volunteers, all of whom were commencing IVF treatment. Each patient was examined in the cycle preceeding the start of drug therapy during the late follicular phase. IF eight or more subcapsular follicles of 2-8 mm in diameter in one

How large is the Swedish 'academic' sector really? A critical analysis of the use of science and technology indicators

Sweden is perceived to be top ranking. and a 'role model', in terms of its volume of academic R&D. This perception is based on analyses using two standard indicators. We assess the validity of these and argue that institutional features skew the result in favour of a high ranking. Swedish academic R&D is more appropriately characterised as average. or below average. in terms of input and a

Cytogenetic abnormalities in 106 oral squamous cell carcinomas

We report karyotypic features of 106 short-term cultured oral squamous cell carcinomas (SCC), 51 new and 55 previously reported cases, with clonal chromosome aberrations. The major cytogenetic findings were as follows: simple karyotypic changes were present in 38 cases (36%) and 68 tumors (64%) displayed complex karyotypes. The most common numerical changes were +7, +8, +9, +16, +18, +20, and -4,

The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery

The contractile and relaxant effects of the different P2 receptors were characterized in the rat isolated mesenteric artery by use of extracellular nucleotides, including the stable pyrimidines uridine 5'-O-thiodiphosphate (UDPbetaS) and uridine 5'-O-3-thiotriphosphate (UTPgammaS). The selective P2X receptor agonist, alphabeta-methylene-adenosine triphosphate (alphabeta-MeATP) stimulated a potent

Hydrogen exchange and hydration dynamics in gelatin gels

Gelatin, derived from the collagen triple helix, is the most widely used functional biopolymer and a prototype for studies of physical gels. Gelatin gels have also served as models for soft biological tissue in efforts to elucidate the molecular basis of the magnetic relaxation phenomena that govern magnetic resonance image contrast. Yet, the microstructure, hydration, and magnetic relaxation beha

Endovascular repair of descending thoracic aortic aneurysms: an early experience with intermediate-term follow-up

PURPOSE: The purpose of this study was to report an initial experience with the endovascular repair of descending thoracic aortic aneurysm. Complications and intermediate-term morphologic changes were identified with the intent of altering patient selection and device design. METHODS: Endografts were placed into 25 patients at high-risk for conventional surgical repair over a 3(1/2)-year period. D

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Abstract in Danish Benign paroksysmal positionel vertigo viser sig ved kraftige rotatoriske svimmelhedsanfald, når patienten bevæger sit hoved i bestemte stillinger. Tilstanden er, som navnet udsiger, benign, men medfører oftest væsentlig morbiditet. Fritflydende otolitter (ørekrystaller) antages at sedimentere i buegangene ved hovedbevægelser. Herved påvirkes cupula hydrodynamisk og dette medføreBenign paroxysmal positional vertigo presents with brief, episodic, positioning-provoked vertigo and characteristic findings on Dix-Hallpike and other positional tests. This article is based on a systematic review of the literature and describes epidemiology, etiology, pathogenesis, diagnostic positional tests and treatment using canalith repositioning, liberatory and 360 degrees rotation manoeuvr

A 10-bit wide-band CMOS direct digital RF amplitude modulator

This paper describes a low-distortion wide-band CMOS direct digital RF amplitude modulator, which uses a 10-bit linear interpolation current-steering digital-to-analog converter (DAC) and a Gilbert-cell-based mixer to generate an amplitude modulated RF signal directly. The linear interpolation increases the attenuation of the DAC's image components. The reconstruction filter is, therefore, elimina