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Background Sex differences in valvular heart diseases have been examined but rarely using a nationwide, comprehensive approach.ObjectivesThe aim of this study was to analyze the risk of different types of valvular heart diseases among males and females in Sweden.MethodsThis was a nationwide Swedish study of all individuals (N = 9,984,758; 4,969,472 males and 5,015,286 females). Valvular heart dise
This article examines Friedrich Schelling’s understanding of the beginning of reality through the concept of contraction and its relation to his view of life as struggle. Drawing on his rejection of mechanistic accounts of life, the article shows how Schelling envisions all life – divine as well as finite – as arising through tension, polarity, and dynamic becoming. God is not a static principle b
Variational Mode Decomposition (VMD) is a powerful formalism for the time-scale analysis of vibration signals from rotating machinery. However, its performance is often compromised by complex parameter configuration, where subjective manual tuning leads to mode mixing or information loss. In this study, we present a physics-guided framework that generalizes VMD optimization across diverse operatin
The capacity of nutrient-limited forests to enhance carbon (C) sequestration under elevated CO2 (eCO2) remains a critical uncertainty in C cycle modeling. While existing evidence suggests that low phosphorus (P) bioavailability may constrain CO2 fertilization effects on plant growth, the extent to which this limitation modulates ecosystem responses to eCO2 in forests adapted to P-deficient soils r
Once rooted in the Cold War experience of small and nonaligned European states, total defense has reemerged across Northern and Eastern Europe in response to Russia’s increasingly aggressive behavior. Finland, Norway, and Sweden are at the forefront of this revival, making total defense central to national security and societal resilience. This article examines why these three structurally similar
Pimavanserin was the first US Food and Drug Administration approved antipsychotic drug that does not block D2 dopamine receptors at therapeutic doses. Pimavanserin is a selective 5-HT2A receptor inverse agonist that reduces the frequency of hallucinations and delusions associated with Parkinson disease. Despite these attributes, pimavanserin prolongs the QT interval at therapeutic doses, limiting
Forskning visar att rika individer har ett större klimatavtryck än befolkningen i stort.Rikedom innebär också symbolisk makt, där de rikas liv och vanor kan påverkanormer för vad som uppfattas som ett gott och eftersträvansvärt liv. Men hur ser densvenska allmänheten på rikedom och rika individer i ljuset av klimatförändringarna?Har rika ett särskilt ansvar att sänka sina koldioxidutsläpp? Och fin
De ultrarikas höga utsläpp väcker frågor om miljardärernas klimatansvar. Ska de som släpper ut mest också minska sina utsläpp mest? Bör de ultrarikas inkomster begränsas eller styras om i ljuset av klimatkrisen? Vad tycker svenska folket? Det är frågor som välfärdsforskare i Lund och Göteborg just nu söker svar på.
Klimatavtryck från Sveriges och världens rikaste har ökat stadigt sedan 90-talet. Samtidigt har de med lägst inkomst minskat sina utsläpp. Nu undersöker forskare om begränsningar för superrika kan bidra till minskade utsläpp. Utopi eller frihetskränkande?
Background Treatment of severe hemophilia A (SHA) with FVIII concentrates is complicated by the development of neutralizing inhibitors in about 30% during the first 50 exposure days (EDs). Despite extensive research, inhibitor risk of different FVIII concentrates remains to be elucidated. Objectives This study aimed to analyze inhibitor development according to (classes of) individual FVIII concen
PURPOSE: We aimed to develop a predictive tool for anastomotic leakage (AL) following colon cancer surgery by combining a clinical early warning score (EWS) with the C-reactive protein (CRP) level.METHODS: The records of 1,855 patients who underwent colon cancer surgery at the Oxford University Hospitals NHS Foundation Trust between January 2013 and December 2018, with or without AL, were retrospe
BACKGROUND: Intestinal resection and a proximal stoma is the preferred surgical approach in patients with severe secondary peritonitis due to perforation of the small intestine. However, proximal stomas may result in significant nutritional problems and long-term parenteral nutrition. This study aimed to assess whether primary anastomosis or suturing of small intestine perforation is feasible and
The EU's Clean Energy Package introduced renewable and citizen energy communities (RECs/CECs) to strengthen citizen participation in electricity markets. Nordic countries, however, have long-standing traditions of community-based energy provision, including district heating cooperatives, small hydropower schemes, and wind cooperatives. This article examines how nationally embedded energy models in
Background: Clinical supervisors’ competence is central to student learning, particularly in the context of existing practical, organizational, and resource-related challenges in simulation-based education. This study explored clinical supervisors’ experience of acting as instructors during simulation-based learning in specialist nursing education in anesthesia and intensive care. Method: An explo
Given the reproducing kernel k of the Hilbert space Hk we study spaces Hk(b) whose reproducing kernel has the form k(1−bb⁎), where b is a row-contraction on Hk. In terms of reproducing kernels this is the most far-reaching generalization of the classical de Branges-Rovnyaks spaces, as well as their very recent generalization to several variables. This includes the so called sub-Bergman spaces [31]
Canopy decline is increasingly prevalent in high-elevation snow gum (Eucalyptus pauciflora) forests across the Australian Alps. This phenomenon, known as snow gum dieback, is associated with infestations by the wood-boring beetle, Phoracantha mastersi. The larvae of this beetle create feeding galleries in the tree trunk, leading to the exudation of kino, a tannin-rich resin produced as a defense r
