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Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions.

Amyloid fibrils are the most distinct components of the plaques associated with various neurodegenerative diseases. Kinetic studies of amyloid fibril formation shed light on the microscopic mechanisms that underlie this process as well as the contributions of internal and external factors to the interplay between different mechanistic steps. Thioflavin T is a widely used noncovalent fluorescent pr

Alcohol consumption and binge drinking in early pregnancy. A cross-sectional study with data from the Copenhagen Pregnancy Cohort.

Since 2007 the Danish Health and Medicines Authority has advised total alcohol abstinence from the time of trying to conceive and throughout pregnancy. The prevalence of binge drinking among pregnant Danish women has nevertheless been reported to be up to 48 % during early pregnancy. Since the introduction of the recommendation of total abstinence, no studies have examined pre-pregnancy lifestyle

Migratory refueling affects non-enzymatic antioxidant capacity, but does not increase lipid peroxidation.

All aerobic organisms are to some degree affected by oxidative stress, which is an imbalance between pro-oxidants and antioxidants in favor of the former. Pro-oxidants can damage DNA, proteins and lipids, and as such oxidative stress can carry considerably fitness costs. In mammals excessive calorie intake is a known cause of oxidative stress. We investigated whether in migrant birds, which typica

Complexes of surfactants with oppositely charged polymers at surfaces and in bulk

Addition of surfactants to aqueous solutions of polyelectrolytes carrying an opposite charge causes the spontaneous formation of complexes in the bulk phase in certain concentration ranges. Under some conditions, compact monodisperse multichain complexes are obtained in the bulk. The size of these complexes depends on the mixing procedure and it can be varied in a controlled way from nanometers up

Particle trajectories in linear water waves

We prove that in linear periodic gravity water waves there are no closed orbits for the water particles in the fluid. Each particle experiences per period a backward-forward motion that leads overall to a forward drift.

Influence of residual stress on the adhesive behavior of detonation gun sprayed WC-Co coatings

The residual stresses generated during D-Gun spraying process act as pre-existing stresses and seriously affect the various types of coating performance. To produce a reliable coating, it is necessary to know the influence of residual stress on the adhesive behavior of coating/substrate system. Based on the residual stress formula for thick coatings and accurate curvature measurements, the residua

Linear programming relaxations and marginal productivity index policies for the buffer sharing problem

We study the dynamic admission control for a finite shared buffer with support of multiclass traffic under Markovian assumptions. The problem is often referred to as buffer sharing in the literature. From the linear programming (LP) formulation of the continuous-time Markov decision process (MDP), we construct a hierarchy of increasingly stronger LP relaxations where the hierarchy levels equal the

Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP.

SUMMARY: The bacterial ω-transaminase from Chromobacterium violaceum (Cv-ωTA, EC 2.6.1.18) catalyzes industrially important transamination reactions by use of the coenzyme pyridoxal 5'-phosphate (PLP). Here, we present four crystal structures of Cv-ωTA: two in the apo form, one in the holo form and one in an intermediate state, at resolutions between 1.35 and 2.4 Å. The enzyme is a homodimer with

Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact

Background. Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters. Material and methods. In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and

Photon echo spectroscopy reveals structure-dynamics relationships in carotenoids

Based on simultaneous analysis of the frequency-resolved transient grating, peak shift, and echo width signals, we present a model for the third-order optical response of carotenoids including population dynamics and system-bath interactions. Our frequency-resolved photon echo experiments show that the model needs to incorporate the excited-state absorption from both the S-2 and the S-1 states. We

Metabolic alterations in patients with self-inflicted aggressive behaviour

Self-inflicted aggressive behaviour is a cross diagnostic phenomenon of major clinical relevance in psychiatric setting. Accumulating evidence speaks for a role of metabolic and immunological factors in aggressive behaviour. The aim of this thesis is to enlighten the role of leptin, insulin, glucagon, glucose and IL-1beta in the context of self-inflicted aggressive behaviour. We used cerebrospinal

Basic Concepts for Convection Parameterization in Weather Forecast and Climate Models: COST Action E50905 Final Report

The research network "Basic Concepts for Convection Parameterization in Weather Forecast and Climate Models" was organized with European funding (COST Action E50905) for the period of 2010-2014. Its extensive brainstorming suggests how the subgrid-scale parameterization problem in atmospheric modeling, especially for convection, can be examined and developed from the point of view of a robust theo

Step enhanced dehydrogenation of ethanol on Rh

We have investigated the adsorption and decomposition of ethanol on the Rh(111) and Rh(5 5 3) surfaces at room temperature with special emphasis on the dehydrogenation. We use high resolution Core level photoemission and density functional theory (DFT) based simulations. A detailed analysis of the C1s core level spectra, including analysis of the vibrational fine-structure and comparison to calcul

Hexadecane mechanisms: Comparison of hand-generated and automatically generated with pathways

In this paper, the automatically generated mechanism for hexadecane with both high and low temperature chemistry included is compared to a systematically generated mechanism by hand. In contrast to other systems for automatic generation, the REACTION system uses pathways to organize the application of reaction classes. A pathway is a sequence of reaction classes where only those species produced b

Contributions to the Teloschistaceae, with particular reference to the Southern Hemisphere

Thirty-five new species of the lichen family Teloschistaceae are described: Caloplaca aseptatospora S. Y. Kondr. & Kärnefelt, C. bartlettii S. Y. Kondr. & Kärnefelt, C. begaensis S. Y. Kondr. & Kärnefelt, C. burneyensis S. Y. Kondr. & Kärnefelt, C. cliffwetmorei S. Y. Kondr. & Kärnefelt, C. dorrigoensis S. Y. Kondr. & Kärnefelt, Caloplaca erichansenii S. Y. Kondr., A. Thell