The identification of novel antimetastatic therapeutic targets is necessary for improved treatment of patients with acquired BRAF inhibitor-resistant (BRAFi-R) melanoma, in whom metastasis is a major concern. Our present study focused on the identification of such targets to explore novel antimetastatic therapeutic options for BRAFi-R melanoma patients. We confirmed the development of BRAFi resist

The carbon cycle of the terrestrial biosphere plays a vital role in controlling the global carbon balance and, consequently, climate change. Reliably modeled CO2 fluxes between the terrestrial biosphere and the atmosphere are necessary in projections of policy strategies aiming at constraining carbon emissions and of future climate change. In this study, SMOS (Soil Moisture and Ocean Salinity) L3

Seminarierapport från 1998-01-29

Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample

Public language is generally considered to have become more informal in the Western world in the past few decades. The same holds true for Swedish public language and the language of Swedish newspapers in particular. However, two former studies of opinion articles in five Swedish newspapers revealed that the language used in this genre was surprisingly unchanged during the time period 1945–2000. T

The aim of this dissertation is to study how positioning among students in the music classroom interplays with music teaching activities as practised in Swedish comprehensive schools. The study uses a videoethnographic technique for documenting interactions between students in two different music classrooms. The one is in a music profile school with students for whom music may be assumed to be imp

Virtually every company has implemented a Business Performance Measurement System (BPMS) with the purpose of monitoring production and business performance and to execute the corporate strategy at all levels in a company. The purpose of this article is to shed light on common pitfalls related to the practical use of BPMS and further to present a life cycle model with the purpose of introducing str

Swedish labour market policy faces major challenges. Sweden has a labour deficit and a very low unemployment rate at the same time as unemployment is high among young people and immigrants. Unemployed in Sweden with high thresholds to enter the labour market are referred to the local labour market policy where the municipalities co-operates, competes and negotiates with the Public Employment Servi

Analyzing the frequency dependent dielectric properties can be used to identify and distinguish materials in biomedical instruments. In the millimeter-wave range, the dielectric properties of biological tissues are mainly determined by their water content. For instance, it has been shown, that cancer cells have a lower water content than healthy skin cells, resulting in a significant dielectric co

This chapter explores how nursing home managers grapple with local manifestations of the wicked problems that plague elderly care. It shows the tension between managers' lofty ideals of high-quality, individualized care and their continuous struggle to handle very basic troubles that ultimately appear to be grounded in a lack of resources, such as high personnel turnover and staff complaints about

This chapter provides the legitimacy of human rights as individual rights of all humans; and the justification of the universality of human rights. It deals with the legitimacy of the impact of the universality of human rights within religious and worldview-based communities. The chapter shows that the patterns of argumentation of different religious and worldview-based communities, or some groups

Non-typeable Haemophilus influenzae (NTHi), a commensal organism in pre-school children, is an opportunistic pathogen causing respiratory tract infections including acute otitis media. Adults suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized by NTHi. Previous research has suggested that, in some bacterial species, the intracellular elongation factor thermo-unst

The remarkable growth of e-commerce has defined the recent years of various industries worldwide. Driven by consumers, the e-commerce surge (e-retail in particular) stems from the final leg of the supply chain: the last mile. As the growing flow of e-commerce orders continues to generate new records for annual revenues, key actors in the last mile face the challenges of increasing customer demands