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Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the brain. We previously showed the presence of PRR in neurons and glial cells in the nigrostriatal system of rodents and primates, including humans.

Overactivity of the angiotensin-type-1 receptor (AT1)/NADPH-oxidase axis enhances aging processes, neuroinflammation and neurodegeneration. The role of AT2 receptors in the above-mentioned AT1-related effects in the aged brain, particularly substantia nigra, was investigated in this study. In the nigra, we observed a progressive decrease in AT2 mRNA expression with aging, and AT2 deletion led to c

The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the ro

Collaboration with Swedish trio Kv.Arken. Premiere of the piece "Sånger från Svartsten" written specifically for the trio’s unique composition, drawing inspiration from both Swedish and Ukrainian folk tunes. Mats has found inspiration for the work from, among other things, Gammelsvenskby and the Jewish klezmer tradition in Ukraine, as well as from the farm Svartsten in Gåsborn in Värmland, where h

The Swedish botanist, Darwinist, socialist, and atheist Bengt Lidforss (1868–1913) passed away one hundred years ago, on September 23, 1913. His research was mainly focused on plant physiology, and the problem of speciation within the genus Rubus (blackberries) in particular came to follow him as a constant mystery. Besides his work as a teacher, researcher, and finally professor of botany at Lund

BACKGROUND: Rehabilitation following traumatic knee injury often focuses primarily on physical aspects. Lack of knowledge of psychological factors and appropriate strategies may be a barrier to meeting treatment recommendations to address these factors.PURPOSE: The aim of this study was to investigate whether, and to what extent, Scandinavian physical therapists address psychological factors in tr

In-cylinder pressure measurements serve as the gold standard for combustion diagnostics in Internal Combustion Engines. However, the associated costs render it unfeasible to equip engines with in-cylinder pressure sensors. For spark-ignited engines, using the more affordable in-cylinder ion current measurements as an alternative to the traditional pressure sensors has shown promising results for c

Sight, hearing, smell, taste and touch: that the senses should be enumerated in this way is not self-evident. The number and order of the senses are fixed by custom and tradition, not by nature. The regular order being subject to occasional change proves its arbitrariness. Therefore, we can describe the enumeration of the five senses as an artificial series of natural elements.

The MNS blood group system antigens (M, N, S, s, U, and other high- and low-frequency antigens) are carried on glycophorins A and B, or hybrid proteins thereof. Antibodies to these antigens can be clinically significant, especially anti-S, anti-s, and anti-U. The Duffy blood group system antigens (Fya, Fyb, Fy3) are carried on the atypical chemokine receptor 1 (ACKR1). Antibodies to the Duffy anti

A common and growing issue in scientific research and industry is that of storing and sharing ever-increasing datasets. In this paper we document the development and applications of Baler - a Machine Learning based tool for tailored compression of data across multiple disciplines.

The Cold War shaped the Danish landscape and cityscape profoundly. Numerous bunkers, military and civilian remain today as testimonies of a time where fear of a nuclear Third World War was imminent. This chapter delves into “the bunker” as materiality and myth, drawing inspiration from bunker studies from a broad range of fields including history, geography and architecture. Subsequently, this cha

Introduction: Understanding violent criminality and its impact on health and eventually the risk of premature mortality is important for efficient future interventions. This study aimed to explore the effect violent criminality had on premature mortality (i.e., death before the age of 65) among individuals with substance use disorders (SUDs). Methods: The cohort was created by identifying all Swed

Stable isotope analysis of plant remains recovered from archaeological sites is becoming more routine. There remains a lack of consensus, however, on how to appropriately select archaeological plant remains for isotopic analysis, how to account for differences in preservation and the effect of potential contamination, and how to interpret the measured isotope values in terms of the conditions in wStable isotope analysis of plant remains recovered from archaeological sites is becoming more routine. There remains a lack of consensus, however, on how to appropriately select archaeological plant remains for isotopic analysis, how to account for differences in preservation and the effect of potential contamination, and how to interpret the measured isotope values in terms of the conditions in w

A modern vehicle typically has up to ten different heat exchangers, ensuring prolonged technology life, improved performance, and passenger comfort. Heat exchangers for automotive applications are made of multilayer-clad brazed aluminium. They are mature products, having been used in passenger and commercial internal combustion engine vehicles for decades, and their use will continue in electrifie

Calcitonin gene-related peptide (CGRP) was suggested to play an important role in primary headaches as far back as 1985 and has been confirmed as playing a significant role in migraine pathophysiology. CGRP receptor antagonists are becoming more and more important for treatment of acute migraine attacks and for prophylaxis of episodic and chronic migraine. The development of drugs that bind CGRP o

Background: Digital work can be cognitively challenging especially for people with cognitive difficulties. New occupational therapy interventions are needed to empower these persons to self-manage challenges in digital work and everyday life. To address this need, the internet-based intervention 'Strategies for Empowering Activities in Everyday Life' (SEE 2.0) was tested.Aim: To explore and descri