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A novel mutation in exon 9 of tau, I260V, is associated with a clinical syndrome consistent with frontotemporal dementia with extensive tau pathology; however, neurofibrillary tangles and Pick bodies are absent. Significantly, Sarkosyl- insoluble tau extracted from affected brain tissue consisted almost exclusively of four-repeat isoforms. Consistent with these findings, in vitro biochemical assay
The stress field in a finite, edge cracked specimen under load is computed using algorithms based on two slightly different integral equations of the second kind. These integral equations are obtained through left regularizations of a first kind integral equation. In numerical experiments it is demonstrated that the stress field can be accurately computed. Highly accurate stress intensity factors
In the normal setting, the release of digestive substances and hormones from the pancreas is closely regulated. However, a variety of diseases, such as acute pancreatitis (AP), may disturb this balance. A limited number of studies on exocrine function in the acute phase of pancreatitis have been performed, most of them in animals. In the convalescent phase of AP, a substantial number of patients w
An understanding of how the cementing technique influences cement penetration is important for surgeons to plan and conduct hip resurfacing procedures. Therefore the aim of this study is to determine the influence of the following parameters on cement penetration: use of pulse lavage, type of cement, and the standing period of the cement. Nine fresh frozen paired whole cadaver femora were used to
Contemporary understanding of the behaviour of surging glaciers and ice streams is hampered by the lack of data on landsystem evolution and sedimentary environments. This study concerns the ice-marginal environment of the surge-type Brúarjökull in Iceland. The sediment distribution in the glacier forefield as well as the morphology, sedimentology and tectonic architecture of the 1890 end moraine i
Today's handheld computing devices equipped with novel wireless network technologies can provide their users with features such as mobility, multimedia support and group communication. On the other hand, the administrative effort required to enable all these features increases beyond the level that an ordinary user can manage. Ad hoc networks, being able to quickly organise themselves without user
The dual-function phosphatase and tensin homolog deleted on chromosome 10 ( PTEN) is the second most frequently mutated gene in human cancers. PTEN counteracts the functions of many growth factors, the most prevalent of which is insulin-like growth factor II ( IGF-II). PTEN expression is stimulated by IGF-II forming a feedback loop. Investigating IGF-binding protein ( IGFBP) modulation of IGF-II a
A novel process modeling tool to facilitate the study of how various process changes in the paper dryer section affect the mill-wide energy system has been developed. A model library with steady-state block models describing paper dryers, heat recovery equipment, and auxiliary systems on component level have been developed using the software Extend. Process models are then created from these block
We present a generic approach for quantitative differential proteomics that reduces data complexity in proteome analysis by automated selection of peptides for MS/MS analysis according to their isotope-labeling ratio. Isotopic reagents were developed that give products which fragment easily to generate a unique pair of signature ions. Using the ion-pair ratio, we show that it is possible to select
Somatic hypermutation (SHM) features in a series of 1967 immunoglobulin heavy chain gene (IGH) rearrangements obtained from patients with chronic lymphocytic leukemia (CLL) were examined and compared with IGH sequences from non-CLL B cells available in public databases. SHM analysis was performed for all 1290 CLL sequences in this cohort with less than 100% identity to germ line. At the cohort lev
Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are only recently coming to light. Potential mechanisms include changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons
Piloderma sp., a wood ash-colonizing ectomycorrhizal (EM) fungus, was grown symbiotically with Norway spruce in microcosms which contained granules of hardened wood ash. Mycelium close to the granules was sampled 3 times over a period of 11 weeks and the elemental content was investigated with particle induced X-ray emission. Mycelium from microcosms without wood ash was used as controls. The cont
Several different factors may determine where species range limits are located within regions of otherwise continuously available habitat and suitable climate. Within the Arctic tundra biome many bird species are migratory and their breeding distributions are affected by migration routes that are in turn limited by factors such as suitable winter habitat, migratory stopover sites, geographical bar
Photofragmentation of small argon clusters with size below ten atoms is reported. In this size range significant modifications from the electronic properties and geometry take place. When tuning the photon energy through the argon 2p edge, the fragmentation pattern is changed. Specifically, cation dimer production is enhanced at the 2p(3/2)-> 4s resonance, while above the 2p edge almost complete a
Interdigitated electrodes made up of two individually addressable interdigitated comb-like electrode structures have frequently been suggested as ultra sensitive electrochemical biosensors. Since the signal enhancement effects due to cycling of the reduced and oxidized species are strongly dependent on the inter electrode distances, since the nature of the enhancement is due to overlying diffusion
We present a theory for two-particle entanglement production and detection in mesoscopic conductors at finite temperature. The entanglement of the density matrix projected out of the emitted many-body state differs from the entanglement of the reduced density matrix, detectable by current correlation measurements. Under general conditions reduced entanglement constitutes a witness for projected en
