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Invasive studies show that the glomerular sieving coefficients for 5–30 kDa plasma proteins in the human kidney may be selectively reduced compared to those for small molecules < 0.9 kDa, commonly used to measure glomerular filtration rate (GFR). Identification of this pathophysiological state, called shrunken pore syndrome (SPS), can easily and non-invasively be done by comparing estimations of G

Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.MethodsIn a cro

Ionotropic glutamate receptors are ligand-gated ion channels governing neurotransmission in the central nervous system. Three major types of antagonists are known for the AMPA-type receptor GluA2: competitive, non-competitive (i.e. negative allosteric modulators; NAMs) used for treatment of epilepsy, and uncompetitive antagonists. We here report a 4.65 Å resolution X-ray structure of GluA2, reveal

Understanding protein aggregation is essential to unveil molecular mechanisms associated with neurodegenerative diseases such as Alzheimer's, Huntington's and spongiform encephalopathy, particularly to determine the role of interaction with cell membranes. In this study, we employ Langmuir monolayers as cell membrane models to mimic interaction with the peptide KTNMHKHMAGAAAAGAVVGGLG−OH, a fragmen

(1) If policy-makers and businesses are to encourage consumers to participate in circular consumption systems, knowledge is needed about what motivates consumers to choose different disposal options. This paper aims to shed light on what motivates consumers to engage in circular home textile disposal practices. (2) Quantitative data was collected through a survey of members of the IKEA Family prog

Over the last few years, there has been a growing concern among academics and practitioners about the slow pace in which sustainability transformations unfold. While most socio-technical transformations tend to happen over extended periods, research shows that unless some dramatic changes are introduced, we are risking damaging the critical earth systems that sustain human life. In this context, u

Economic geographers have recently made important contributions to understanding of the relationship between regional transformation, industrial specialisation and innovation networks in the emergence of new industries. However, most contemporary research has focused on the influence of networks on regional trajectories, paying lip service to how regional trajectories also influence network config

We present a semi self-aligned processing scheme for III-V nanowire transistors with novel semiconductor spacers in the shape of Λ-ridges, utilising the effect of slow growth rate on {111}B facets. The addition of spacers relaxes the constraint on the perfect alignment of gate to contact areas to enable low overlap capacitances. The spacers give a field-plate effect that also helps reduce off-stat

Two sets of diesel injectors are tested in combination with common fuel additives in a multi-cylinder light-duty diesel engine. One set consists of new injectors and the other is aged by over 100,000 km use in a vehicle. Four fuels are tested with these injector sets to investigate the impact of fuel additives on combustion and emission characteristics. The results show that the aged injectors con

High-speed imaging of fuel sprays and combustion is conducted on a light-duty optical engine to investigate the effects of injector aging, with a focus on soot. The spray behaviors of one new and one aged injector are compared using Mie-scattering. In addition to this, the combustion process of a baseline diesel fuel and a blend with TPGME (tripropylene glycol monomethyl ether) are compared using

In this paper I want to examine some consequences that archival strategies of mass digitized environments might have on people’s relations to the history of recorded music. Archival strategies can make user-listeners connect tracks in surprising ways due to recommendation systems; they can make user-listeners get lost in the abundance of music; they can give user-listeners the impression that ther

PTCL patients exhibit poor survival with existing treatments. We investigated the efficacy of CHOP combined with alemtuzumab in 116 PTCL patients age 61–80 in an open-label, randomized phase 3 trial. Alemtuzumab was given on day 1, to a total of 360 mg in 21 patients, or 120 mg in 37. Hematotoxicity was increased with A-CHOP resulting in more grade ≥3 infections (40% versus 21%) and 4 versus 1 dea

Lifetimes of low-lying states in 73Ga and 70,72,74Zn were measured using the Recoil Distance Doppler Shift (RDDS) method. These nuclei were produced in deep-inelastic reactions in inverse kinematics with a 208Pb beam impinging on a 76Ge target. Prompt γ rays were detected using the AGATA tracking array coupled to the VAMOS++ spectrometer. Lifetime of the 5/2- state in 73Ga, measured for the first

Objective: Observational studies point to an inverse correlation between low-density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically elevated LDL is associated with reduced risk of ICH. Methods: We constructed one polygenic risk score (PRS) per lipid trait (total ch

Background: Intravesical instillation of bacillus Calmette-Guérin (BCG) is an accepted strategy to prevent recurrence of non–muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity. Objective: NIMBUS assessed whether a reduced number of standard-dose BCG instillations are noninferior to the standard number and dose in patients with high-grade NMIBC. Design, setting, and par