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Depletion interaction between spheres in an ideal equilibrium polymer fluid: Exact asymptotic results

We use a continuum chain model and develop an analytical theory for the interaction between two spheres immersed in a fluid of ideal equilibrium polymers. The theory can be applied to both adsorbing and nonadsorbing spheres. Here we focus on two nonadsorbing spheres and determine the classical depletion interaction between them. Compact, and exact, results are derived for the asymptotic behavior o

Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation.

Because of the continuous increases in lifetime expectancy, the incidence of age-related diseases will, unless counteracted, represent an increasing problem at both the individual and socioeconomic levels. Studies on the processes of blood cell formation have revealed several shortcomings as a consequence of chronological age. They include a reduced ability to mount adaptive immune responses and a

An alternative methodology for the analysis of electrical resistivity data from a soil gas study

The aim of this paper is to present an alternative method for the analysis of resistivity data. The methodology was developed during a study to evaluate if electrical resistivity can be used as a tool for analysing subsurface gas dynamics and gas emissions from landfills. The main assumption of this study was that variations in time of resistivity data correspond to variations in the relative amou

Motor and non-motor predictors of illness-related distress in Parkinson's disease.

OBJECTIVE: To identify motor and non-motor symptoms independently associated with distress in Parkinson's disease (PD). METHOD: Clinical and patient-reported data from 118 people with PD (mean age and PD-duration, 64 and 8 years) were analyzed regarding associations with patient-reported distress using multiple regressions (controlling for age). RESULTS: Non-motor symptoms independently associated

Identifying dietary patterns using a normal mixture model: application to the EPIC study

Background Finite mixture models posit the existence of a latent categorical variable and can be used for probabilistic classification. The authors illustrate the use of mixture models for dietary pattern analysis. An advantage of this approach is taking classification uncertainty into account. Methods Participants were a random sample of women from the European Prospective Investigation into Canc

Anxiety in close relationships is higher and self-esteem lower in patients with irritable bowel syndrome compared to patients with inflammatory bowel disease.

BACKGROUND: Previous research has suggested an interaction between personality factors and inflammatory bowel disease (IBD) as well as irritable bowel syndrome (IBS). We therefore aimed to elucidate differences in psychological and coping functioning between patients with IBD and IBS, and to assess the relationship of disease activity with these functions. METHODS: Seventy-four patients with IBD (

Cost of multiple sclerosis in the Czech Republic: The COMS study

Background: Information about cost of multiple sclerosis (MS) is available from a number of European countries, but no data from the Czech Republic have been published so far. Objective: The objective of this study was to establish the cost of MS in the Czech Republic, overall and by level of disease severity. Methods: Data on demographics, disease history, resource consumption and production loss

Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative

The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes. We performed a subanalysis among 4,220 individuals with diabetes in a large ongoing individual participant data meta-analysis involving 56,194 subjects from 17 population-based cohorts worldwide. We first refitted

Generation of miniaturized planar ecombinant antibody arrays using a microcantilever-based printer.

Miniaturized (Ø 10 μm), multiplexed (>5-plex), and high-density (>100 000 spots cm(-2)) antibody arrays will play a key role in generating protein expression profiles in health and disease. However, producing such antibody arrays is challenging, and it is the type and range of available spotters which set the stage. This pilot study explored the use of a novel microspotting tool, Bioplume(TM)-cons

The role of Grassroot Leaders in building Networks and organizing Learning Groups

In recent years questions concerning whether and how networks between small and medium-sized enterprises (SMEs) can serve as platforms for inter-organizational collective learning have attracted interest. In the present paper it is argued that two prerequisites for this are recognition of common needs and goals that contribute to the construction of a collective identity and the presence of promot

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and impor

Eemian interglacial reconstructed from a Greenland folded ice core

Efforts to extract a Greenland ice core with a complete record of the Eemian interglacial (130,000 to 115,000 years ago) have until now been unsuccessful. The response of the Greenland ice sheet to the warmer-than-present climate of the Eemian has thus remained unclear. Here we present the new North Greenland Eemian Ice Drilling ('NEEM') ice core and show only a modest ice-sheet response to the st

Spallation target cryogenic cooling design challenges at the European Spallation Source

The European Spallation Source (ESS) project is a neutron spallation source research facility currently being designed and built outside of Lund, Sweden. A linear accelerator delivers a 5 MW, 2.0 GeV, 62.5 mA proton beam to a spallation target to generate fast neutrons. Supercritical hydrogen circulates through two moderators surrounding the target, and transforms the fast neutrons emitted into sl

Phylogenetic relations of the dinoflagellate Gymnodinium baicalense from Lake Baikal

Freshwater dinoflagellates still remain poorly studied by modern biological methods. This lack of knowledge prevents us from understanding the evolution and colonization patterns of these ecologically important protists. Gymnodinium baicalense is the most abundant, and possibly endemic, planktonic dinoflagellate from the ancient Lake Baikal. This dinoflagellate species blooms in the spring under t