Introduction: Head-to-head evaluation of valoctocogene roxaparvovec, the first gene therapy approved for haemophilia A, with emicizumab is not available. Therefore, phase 3 trial data were indirectly compared. Aim: To compare bleeding rates in trials evaluating 6 × 1013 vg/kg valoctocogene roxaparvovec (GENEr8-1; NCT03370913), 1.5 mg/kg emicizumab dosed every week (HAVEN 3; NCT02847637), and FVIII

We describe glaci-lacustrine sediments buried under thick tills in Folldalen, south-east Norway, a site located close to the former centre of the Scandinavian Ice Sheet. Thus, the location implies that the ice sheet had melted when the sediments were deposited. The exposed ground was occupied by arctic vegetation. The best age estimate from 20 quartz luminescence dates is 55.6 ± 4.6 ka. Due to pos

Företag marknadsför över 200 mjukvaror för artificiell intelligens (AI) inom radiologi.Vårdgivare behöver ha möjlighet till opartisk och kvalitetssäkrad utvärdering.Projektet Validering av AI inom bröst­radio­­­logi (VAI-B) startades för att möta detta behov, initialt inom mammografi­screening.

Smart contracts are programs with data (mutable state); stored on and executed by blockchain platforms. The transactions (or function invocations) dispatched to smart contracts often change their state. In the Ethereum blockchain, nodes (aka miners/validators) can schedule a set of transactions in any order in a block. Multiple transactions in a single block operating on a contract's shared state

The present communication describes the use of an emissions barrier to prevent spread of hydrolysis products from plastizisers in plastic mats and from the glue used to attach such mats onto a concrete slab. In particular, 2-ethylhexanol was focussed at. Elevated air concentrations of 2-ethylhexanol has been associated with a range of health symptoms such as e.g. cough, airways irritation, fatique

Objectives To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients. Setting Outpatient treatment. Participants Participants with a diagnosis of COVID-19 and the associated SARS-CoV-2 virus irrespective of age, sex and comorbidities. Interventions Dru

We present an updated version of the QCD-based colour reconnection model in Pythia8, where we constrain the range in impact parameter for which reconnections are allowed. In this way, we can introduce more realistic colour reconnections in the Angantyr model for heavy ion collisions, where previously only reconnections within separate nucleon sub-collisions have been allowed. We investigate how th

Hanteringen av stallgödsel i jordbruket orsakar en stor del av utsläppen av ammoniak i Sverige. För att uppnå Sveriges mål om att minska utsläppen av ammoniak behöver jordbrukare utföra åtgärder som minskar utsläppen av ammoniak. Samtidigt är det viktigt att ta hänsyn till hur åtgärder som minskar ammoniakutsläppen också kan bidra till att minska utsläpp av växthusgaserna metan och lustgas. Här di

Introduction: Female surgeons remain a minority within the field of orthopaedics, particularly in certain specialties such as arthroplasty. There is no scientific evidence on whether the surgeon's sex affects the patient-reported outcome after orthopaedic surgery such as total hip arthroplasty (THA). We therefore aimed to investigate the association between surgeon sex and health-related quality o

[Context] Accurate time estimation is a critical aspect of predictable software engineering. Previous work shows that low source code quality increases the uncertainty in issue resolution times. [Objective] Our goal is to evaluate how developers' project experience and file ownership are related to issue resolution times. [Method] We mine 40 proprietary software repositories and conduct an observa

In recent years, the need for sustainable practices within the food industry has become increasingly important and incorporating Industry 4 [...]

Cosmological models and their parameters are widely debated, especially about whether the current discrepancy between the values of the Hubble constant, H 0, obtained by Type Ia supernovae (SNe Ia) and the Planck data from the cosmic microwave background radiation could be alleviated when alternative cosmological models are considered. Thus, combining high-redshift probes, such as gamma-ray bursts

High-performance broadband photodetectors offering spectral tunability and a high gain-bandwidth product are crucial in many applications. Here, we report on a detailed experimental and theoretical study of three-terminal phototransistors comprised of three million InP nanowires with 20 embedded InAsP quantum discs in each nanowire. A global, transparent ITO gate all around the nanowires facilitat

In this chapter, we explore how audit professionals in transnational accounting firms feel about their professional identity in the digital age. Based on 15 interviews with audit professionals, our findings reveal that despite the dispositional and relational affordances of emerging digital technology, some auditors are experiencing professional insecurities. Our interviewees expressed concerns on

När de regionala högskolorna i Sverige expanderade förbättrades möjligheterna att utbilda sig i olika delar av landet avsevärt. Men frågan är om ökad tillgänglighet till högre utbildning får fler att stanna kvar på landsbygden. I den här rapporten undersöker vi hur avståndet till högskolan påverkar utflyttning från landsbygden.Vi finner att högutbildade lämnar landsbygden i högre utsträckning än a

The implementation of attosecond photoelectron-photoion coincidence spectroscopy for the investigation of atomic and molecular dynamics calls for a high-repetition-rate driving source combined with experimental setups characterized by excellent stability for data acquisition over time intervals ranging from a few hours up to a few days. This requirement is crucial for the investigation of processe

This chapter aims to enhance our understanding of the implications international standardisation have for audit innovation at the national level. The study analyses the ways in which transnational regulation effectuates institutional constraints on audit innovation in Sweden as a setting to discuss the capacity for the audit profession to innovate and make audits more socially relevant. Based on d

Complement-mediated kidney diseases are ultrarare conditions characterized by excess complement activation related in most cases to complement gene variants or circulating autoantibodies. These conditions are chronic and can lead to kidney failure. They include atypical hemolytic uremic syndrome (aHUS), C3 glomeru-lopathy (C3G), and, to a certain extent, immune complex-membranoproliferative glomer

I det här kapitlet beskrivs och diskuteras hur utvecklingen av etiska reglerför revisorer har skett i samverkan med utvecklingen av branschen ochsamhället. Det framgår hur regler använts för att disciplinera revisorernaoch för att öka intressenternas förtroende när det behövts för att stärkaden professionella legitimiteten och yrkets status i samhället.

Background: Peripheral nerve injuries cause substantial problems when not treated properly. A specific problem is reconstruction of nerve defects, which can be treated in different ways. This study aimed to systematically review whether processed nerve allograft (PNA) is justified in reconstruction of a nerve defect in patients after posttraumatic or iatrogenic peripheral nerve injury and to compa