Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacologic

The retrospective investigation was carried out to assess whether subjects who fulfilled our proposed recruitment criteria responded more favorably to anterior cruciate ligament reconstruction (ACLR) than those who did not. We retrospectively analyzed 109 skeletally mature subjects (78 men and 31 women) according to the following proposed criteria of recruitment: (1) pre-injury Tegner activity sco

Cone calorimeter and controlled atmosphere cone calorimeter experiments were conducted on various samples. The intent of the tests was to examine the behavior of uniform and composite samples in a range of thicknesses, irradiances, and oxygen concentrations. Single, uniform layers of acrylonitrile butadiene styrene (ABS) were compared to a composite mix, comprising of ABS with a surface layer of c

Various weather phenomenon are difficult to model and forecast with high precision. This study has modelled and forecasted the various parameter namely maximum and minimum temperature, morning and evening relative humidity using parametric models namely Autoregressive Integrated Moving Average (ARIMA) and Generalized Autoregressive conditional heteroskedasticity (GARCH)) models. The data consisted

Current global change substantially threatens pollinators, which directly impacts the pollination services underpinning the stability, structure and functioning of ecosystems. Amongst these threats, many synergistic drivers, such as habitat destruction and fragmentation, increasing use of agrochemicals, decreasing resource diversity, as well as climate change, are known to affect wild and managed

Calmodulin (CaM) is a ubiquitous Ca2+ sensing protein that binds to and modulates numerous target proteins and enzymes during cellular signaling processes. A large number of CaM-target complexes have been identified and structurally characterized, revealing a wide diversity of CaM-binding modes. A newly identified target is creatine kinase (CK), a central enzyme in cellular energy homeostasis. Thi

The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part,

Aquaporins (AQPs) are membrane channel proteins that facilitate the movement of water down osmotic gradients across biological membranes. This protocol allows measurements of AQP-mediated water transport across the plasma membrane of live mammalian cells. Calcein is a fluorescent dye that is quenched in a concentration-dependent manner. Therefore, on short timescales, its concentration-dependent f

The main premise of Self-Service Business Analytics (SSBA) is to make business employees autonomous during the data analytical process. To empower business employees, organizations are decentralizing their analytical capabilities through an SSBA approach. Yet, little is known about how employees integrate resources, such as, among others, personal competencies, environment resources including tech

Data philanthropy, which is firm donations of data, data scientists, and data technologies for social good, is a powerful new phenomenon that offers benefits to both donor firms and society. In this explorative research we unpack data philanthropy, providing definitions, and examples along with a theoretical perspective from corporate philanthropy and strategic management. We view data through a l

Among the major IT security challenges facing organizations is non-malicious employee behavior that nevertheless poses significant threats to an organization's IT security. Using a grounded theory methodology, this paper finds that organizational security behaviors are inherently related to employee assumptions regarding the importance of IT security policy compliance and regarding the reason why

Striving to promote the health and well-being of their workforce and decrease insurance expenditures, many organizations are incorporating wearable fitness trackers into their corporate wellness programs. Research suggests that these devices encourage individuals to make healthier choices; however, little is known about the drivers and impact of fitness trackers on employee health and wellbeing. W

In this introduction we provide an overview of research on gender issues in the rescue services in combination with introducing the different contributions in this book. The overview is primarily concerned with three national contexts, the US, the UK and Sweden, and we focus on the most prevalent themes in the literature as well as pointing out under-researched areas. The empirical contributions i

In this paper, super-resolution imaging is described and evaluated for x-ray tomography and is compared with standard tomography and upscaling during reconstruction. Blurring is minimized due to the negligible point spread of photon counting detectors and an electromagnetically movable micro-focus x-ray spot. Scans are acquired in high and lowmagnification geometry, where the latter is used to min

Objective To understand and report on the impact of the COVID-19 pandemic on the everyday lives of frail older persons living in nursing homes by exploring their experiences of how the pandemic-related restrictions had influenced them and in what way. Design Empirical qualitative interview study. Setting A publicly run nursing home in an urban area in Sweden in June 2020. The nursing home had visi

In vitro differentiation of human pluripotent stem cells (hPSCs) offers a genetically tractable system to examine the physiology and pathology of human tissue development and differentiation. We have used this approach to model the earliest stages of human B lineage development and characterize potential target cells for the in utero initiation of childhood B acute lymphoblastic leukemia. Herein,

Cooperative binding is a key feature of metabolic pathways, signaling, and transport processes. It provides tight regulation over a narrow concentration interval of a ligand, thus enabling switching to be triggered by small concentration variations. The data presented in this work reveal strong positive cooperativity of α-synuclein binding to phospholipid membranes. Fluorescence cross-correlation