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CD44/CD70 blockade and anti-CD154/LFA-1 treatment synergistically suppress accelerated rejection and prolong cardiac allograft survival in mice.

Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD70 blockade and anti-C

Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols.

Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and hig

Changes to a Municipal Workplace

Det är en recension av en bok som handlar om omvandlingen av Köpenhamns elverk från kommunalt affärsverk till konkurrensutsatt bolag verksamt inom EU. En viktig aspekt är de anställdas anpassning till denna förändring.

RIFM fragrance ingredient safety assessment, Benzyl propionate, CAS Registry Number 122-63-4.

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp

Grammatikalisering i nutid - utvecklingen av typ fram till 2009

In modern Swedish, the word typ has a number of functions and meanings. Until about 1930, typ had, however, only a nominal function, and the other uses of typ have accordingly developed successively during the 20th century. In this article, which is based on a paper by Skärlund (2010), we track the grammaticalization of typ by utilizing electronic corpora, mainly comprising Swedish newspaper texts

Hypoxia increases susceptibility of non-small cell lung cancer cells to complement attack.

The complement system can be specifically targeted to tumor cells due to molecular changes on their surfaces that are recognized by complement directly or via naturally occurring antibodies. However, tumor cells often overexpress membrane-bound complement inhibitors protecting them from complement attack. We have previously shown that non-small cell lung cancer (NSCLC) cells, additionally to membr