Sökresultat

Background: Prediction methods are increasingly used in biosciences to forecast diverse features and characteristics. Binary two-state classifiers are the most common applications. They are usually based on machine learning approaches. For the end user it is often problematic to evaluate the true performance and applicability of computational tools as some knowledge about computer science and stat

This is the first impact analysis that exclusively deals with R&D funding taking place after the foundation of VINNOVA. Since the long-term effects of R&D projects are visible only years after the ending of the projects the analysis deals with impacts expected to be found in a shorter time span. The focus of the present impact analysis is to identify and analyze the presence and strength o

On the history of Scotland.

The mixing process in a Lightnin Series 45 static mixer, 40 mm in diameter, has been investigated using computational fluid dynamics and the volume of fluid (VOF) method, a method developed for immiscible fluids but here used for miscible. The mixing process was investigated for two liquids that had viscosities ranging from 0.003 to 51.2 Pa s, and the volumetric flow rate proportion between the li

This paper explores the control effect of a moral brand through its brand culture. The moral brand culture distinguishes itself from other brand cultures by drawing on external claims for legitimacy. In this case, the brand drew upon a strong brand community, moral narratives in society, and the participative engagement with its values by many employees. As a consequence of these multiple and ofte

Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet a

A series of aromatic mono- or diamido-thiodigalactoside derivatives were synthesized and studied as ligands for galectin-1, -3, -7, -8N terminal domain, and -9N terminal domain. The affinity determination in vitro with competitive fluorescence-polarization experiments and thermodynamic analysis by isothermal microcalorimetry provided a coherent picture of structural requirements for arginine-arene

Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antib

This Letter describes the measurement of elliptic flow of charged particles in lead-lead collisions at root s(NN) = 2.76 TeV using the ATLAS detector at the Large Hadron Collider (LHC). The results are based on an integrated luminosity of approximately 7 mu b(-1). Elliptic flow is measured over a wide region in pseudorapidity, vertical bar eta vertical bar < 2.5, and over a broad range in transver

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy individuals, which has led to the assumption that the disorde

Differential heating of surface waters of lakes caused by shading from vegetation can induce convection, which could be significant for the ecosystem because the chemistry and biology can differ in the reed belt zone compared to the open lake. This process has been given little attention in the literature. In the present study surface currents just outside a reed belt as well as radiation and wate

The active phase of Pd during methane oxidation is a long-standing puzzle, which, if solved, could provide routes for design of improved catalysts. Here, density functional theory and in situ surface X-ray diffraction are used to identify and characterize atomic sites yielding high methane conversion. Calculations are performed for methane dissociation over a range of Pd and PdOx surfaces and reve

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2- h glucose level (rs10423928, beta (s.e.m.)

Innate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the metabolic gene, heme oxygenase-1 (HO-1) in tumor microenvironment imparts significant effects on prostate cancer progression. We showed that HO-1 is expressed in MARCO-positive macro

Synchronous e-learning has received much less research attention, as compared with asynchronous e-learning. Practitioners that consider using and designing synchronous e-learning are in urgent need of guidance. In order to address this need, we propose design exemplars for synchronous e-learning. They are directed towards a primary constituent community of teachers, administrators, managers and de

A method to compute antenna Q using an electromagnetic simulation at a single frequency is described. This method can easily be integrated into global optimization algorithms. In this way the optimization time of some antenna parameters, e.g., bandwidth, may be significantly reduced. The method is validated by direct comparison with the physical bound of the analyzed structure. Numerical examples

A considerable part of black alder swamps in Europe are situated in south Sweden. These swamps are frequently rich in bryophytes, but the variation in species composition is often large between sites. In this study we focus on environmental variables that best predict biodiversity in terms of species number, cover and bryophyte composition. The bryophyte vegetation was analysed in 71 plots of size