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Objective: To develop a model and methodology for predicting the risk of Gleason upgrading in patients with prostate cancer on active surveillance (AS) and using the predicted risks to create risk-based personalised biopsy schedules as an alternative to one-size-fits-all schedules (e.g. annually). Furthermore, to assist patients and doctors in making shared decisions on biopsy schedules, by provid
Multiple sclerosis (MS) is a chronic neurological disease believed to be caused by autoimmune pathogenesis. The aetiology is likely explained by a complex interplay between inherited and environmental factors. Genetic investigations into MS have been conducted for over 50 years, yielding >100 associations to date. Globally, the strongest linkage is with the human leukocyte antigen (HLA) HLA-DRB5*0
Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD. Design, Setting
The purpose of this dissertation was to examine what Smart City concept entails in practice rather than a theory, with a clear secondary focus on digitization and collaboration as the means to deliver successful Smart City projects. This project sheds light on the public actor’s managerial perspective on many actual topics for the globalized world, where cities play a pivotal role. By interviewing
In order to answer the question in the title, a cross-cultural analysis of two countries was done. Countries chosen were the Republic of Latvia and the Kingdom of Spain. The need for this research was suggested by increased cross-border business activities inside the European Union, and the lack of previous studies involving new Member States. The aim of the research was to see what environmental
Public participation in environmental decision-making has been increasingly recognised in national, regional and international law in the last decades. In parallel, the World Bank - an inter-state development bank and international organisation - has developed a set of safeguard policies including provisions on public participation in environmental decision-making. Public participation is about re
It is frustrating for every reasonable human being to observe scenes of exploitation around the world in respect of children, because of their either naivety or vulnerability. It is unacceptable that still in the 21st century, children do not benefit from the protection, attention and love they deserve. An estimated 300 million children worldwide are subject to violence, exploitation and abuse inc
This thesis analyses whether intellectual property rights promote or restrain technology transfer to developing countries and what effect the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement have on technology transfer to developing countries. Technology transfer is traditionally used as a means to increase the technological knowledge of countries, and there hav
In the early 21st century, deflationary trends applied pressure on margins in a range of different industries and subsequently cost reductions were required. Improving efficiency in the supply chain was identified as one of the key sources of potential cost savings. Subsequently, a trend towards slimmer supply chains with less stockkeeping emerged. However, due to the covid-19 pandemic supply chai
Abstract Hydrogen as an alternative energy carrier has been up for discussion over decades. Perhaps this time, however, the political momentum and global technical context could be advantageous enough for the hydrogen economy to finally materialize. Despite investments from the EU commission up to €470 billion in renewable hydrogen, there are economical challenges in the way of decarbonisation of
The comprehensive use of plastic globally has raised many questions about how it will affect living organisms once it is disposed of and reaches the ecosystem. Disposing of plastic in high amounts without recycling could lead to several toxic effects for aquatic organisms and eventually humans. Accumulation of plastic for a long time leads to its aggregation and/or degradation into small sizes in
Title: The importance of creating a credible brand in the new digital world of social media influencer marketing. Submission date: May 29th, 2019 Course: BUSN39 Degree project in global marketing Authors: Sandra Juncker & Charlotta Carlquist Supervisor: Javier Cenamor Keywords: Social media, Social media influencer marketing, Social media influencer Influencer marketing, Influencers, Brand Cre
European rivers experience increasing concentrations of total organic carbon (TOC) from terrestrial sources due to factors involving changes in land use, climate and soil acidity. However, low interest is given to the evolution of total organic nitrogen (TON) concentrations in surface waters, the links with TOC concentrations and the influence of the surrounding land cover on nutrient inputs. Inve
Popular science Glaciers are very sensitive indicators of climate change. The major cause of melting glaciers is global warming. This rapid rate of melting has serious negative impact on the earth causing flooding, leaving impact on flora and fauna, resulting in shortage of freshwater and hydroelectricity. The long-term monitoring of glaciers and the knowledge gained from it can help governments,
The Tam Giang-Cau Hai lagoon system, two inter-connected and naturally occurring coastal lagoons located in the Thua Thien-Hue province of Vietnam, comprises two inlets: Thuan An and Tu Hien. The Thuan An and Tu Hien inlets connect the lagoon system to the South China Sea and they are subjected to morphologic changes due to sediment transport effects. The magnitude of sediment transport is determi
This master thesis analyzes the accounting and auditing reforms in the Post-Soviet world. It is the very interesting issue, because comparing with the rest of Europe and Asia the former soviet countries have extra challenges in this process. They are not only trying to adopt international accounting and auditing standards, but also move away from command economy which is not an easy task. The regu
The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.
Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certainty of evidence (CoE) domains and evidence-to-decision (EtD) criteria. Study Design and Setting We conducted a scoping r
In many machine learning tasks, the premise is designed around predetermined targets and clear expectations of model behaviour. In such cases, there is a direct definition of the optimal mappings between inputs and outputs, which can be learned given sufficiently sized datasets and models. However, in many real-world scenarios, tasks are often not as well-posed and instead defined around detecting
