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Abstract in UndeterminedBearing in mind the potential and importance of enzymatic processes it is somewhat surprising that we are not yet able to fully exploit the possibilities that such processes offer. The main reason is that we do not know the mechanism on the molecular scale in terms of the interaction between the enzyme and the substrate or rather the assembly of substrate molecules (see Fig
Popular Abstract in Swedish För att öka förståelsen för hur ljud sprider sig och strålar från byggnadskonstruktioner utförda i lättbyggnadsteknik så behövs teoretiska beräkningsmodeller. Sådana modeller presenteras i avhandlingen. Med lättbyggnadsteknik avses konstruktioner som inte är massiva, exempelvis väggar och bjälklag bestående av trä- eller stålreglar/bjälkar. Stegljudet, det vill säga detIn order to increase our knowledge of the sound transmission and radiation processes of lightweight wall and floor structures, theoretical models are needed. Detailed models may form a valuable tool. In lightweight floor structures, impact sound insulation is perhaps the most important property to consider. This thesis presents an overview of various solution strategies that may be useful in findi
Global land-use change has drastic consequences for biodiversity leading to losses of ecological functioning, ecosystem services and human well-being. While species dependent on undisturbed natural habitat are most affected by conversion to agriculture, even populations of disturbance-tolerant species can be endangered in landscapes dominated by high-input mono-cultural cropping systems. This has
Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. Our group has developed a recombinant antibody micr
Background: Recent randomized trials demonstrated that laparoscopic lavage compared with resection for Hinchey III perforated diverticulitis was associated with similar mortality, less stoma formation but a higher rate of early reintervention. The aim of this study was to compare 1-year outcomes in patients who participated in the randomized Scandinavian Diverticulitis (SCANDIV) trial. Methods: Be
NOx pollution from diesel engines has been stated as causing over 10 000 pre-mature deaths annually and predictions are showing that this level will increase [1]. In order to decrease this growing global problem, exhaust after-treatment systems for diesel engines have to be improved, this is especially so for vehicles carrying freight as their use of diesel engines is expected to carry on into the
We report the first successful use of miniature Global Positioning System loggers to track the ocean-going behaviour of a c. 400g seabird, the Manx Shearwater Puffinus puffinus. During three field seasons, breeding birds were tracked during the incubation and chick rearing periods on their foraging excursions from the large colony on Skomer Island, Pembrokeshire, UK. Foraging effort was concentrat
Popular Abstract in Swedish Det finns många skäl till varför streptomyceter är en intressant grupp av bakterier att undersöka. Den här avhandlingen fokuserar på celldifferentieringen hos dessa organismer och deras förmåga att bilda en specialiserad typ av tåliga celler som kallas sporer. Genom att studera sporuleringsprocessen hos dessa bakterier kan man lära sig mycket om fundamentala livsprocessStreptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i
The Arena and the Entrepreneurial City builds on a microhistory of the collaboration between public and private organizations in the creation of two public sports arenas. Several new arenas have been built in Sweden during the last 15 years and many of them have received a lot of attention because of cost overruns and design flaws. Previous research shows that there are no economic incentives for
The Siemens gas turbine SGT-800 is the largest industrial gas turbine produced by Siemens Industrial Turbomachinery (SIT) offering a dry low emission (DLE) capability below 15 ppm NOx. It has a very high reliability using an annular combustor system with passive damping and 30 DLE burners. To obtain a greater understanding of the mixing process and the flame dynamics and in order to further reduce
Abstract: Background: During breast cancer progression, the epithelial to mesenchymal transition has been associated with metastasis and endocrine therapy resistance; however, the underlying mechanisms remain elusive. To gain insight into this process, we studied the transition undergone by MCF7-derived cells, which is driven by the constitutive nuclear expression of a MKL1 variant devoid of the a
This is a review of the recent publication “Pharmaceutical Innovation, Competition and Patent Law – A Trilateral Perspective”, edited by Max Planck Director Josef Drexl and Finnish scholar Nari Lee (Edward Elgar 2013, 322 p., ISBN 978 0 85793 245 7). In summary, I conclude that the editors, who also contributed with excellent papers, have succeeded very well in the difficult task of structuring, s
Abstract Since the late 1970’s, China has rapidly increased its exports of industrial products and inflow of foreign direct investment (FDI) through the use of special economic areas (SEA), which offer special benefits to foreign investors and export producers. Common criticism against these SEAs, usually states that these areas show persistent low-standard working conditions and wages to remain c
Monitoring soil moisture at the Earth'surface is of great importance for drought early warnings. Spaceborne remote sensing is a keystone in monitoring at continental scale, as satellites can make observations of locations which are scarcely monitored by ground-based techniques. In recent years, several soil moisture products for continental scale monitoring became available from the main space age
A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In this large multicenter amyloid and tau positron emission tomography (PET) study (n = 1,325), we examined the
The possibility to have a strongly first order electroweak phase transition, which is one of the Sakharov conditions for electroweak baryogenesis together with $\mathcal{CP}$ violation and baryon number violation, in general Two-Higgs-Doublet Models (2HDMs) is here investigated. Different kinds of $\mathbb{Z}_{2}$ breaking beyond standard assumptions are studied, in particular by allowing it to be
Background: Alleviating poverty is critical for achieving sustainability (Zomorrodi et al., 2019). One business approach to alleviate poverty is the Bottom of the pyramid (BoP) approach which implies engaging the poor in doing business, and including them into supply chains with both profitability and poverty alleviation as objectives (Brix-Asala et al., 2021). The populations living in the BoP ar
