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Introduction: The operational definitions of treatment response, partial response, and remission in obsessive-compulsive disorder (OCD) are widely used in clinical trials and regular practice. However, the clinimetric sensitivity of these definitions, that is, whether they identify patients that experience meaningful changes in their everyday life, remains unexplored.Objective: The objective was t
Radiogenic isotopes provide an important means towards elucidating Archean crustal evolution. The global Hf and Nd isotope record of Archean crustal fragments has been instrumental to unveiling the history of ancient crustal growth and differentiation. The Rb-Sr system could provide valuable complementary constraints in this regard, as this system is particularly sensitive to magmatic fractionatio
Water purification is one of the most essential services provided by wetlands. A lot of concerns regarding wetlands subjected to climate change relate to their susceptibility to hydrological change and the increase in temperature as a result of global warming. A warmer condition may accelerate the rate of decomposition and release of nutrients, which can be exported downstream and cause serious ec
Terrestrial water storage (TWS) is a crucial indicator of regional water balance and water resources changes. Due to limited hydrological observations, we combined the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GRACE-FO) products using the Long Short-Term Memory (LSTM) neural network to monitor the TWS changes from April 2002 to March 2020 over the closed Qaidam Basin in
Background: The effect of interleukin 17-inhibitors on anterior uveitis (AU) in spondyloarthritis (SpA) is poorly understood. This study aimed to compare the risk of AU during treatment with secukinumab versus tumour necrosis factor inhibitors (TNFi). Methods: Patients with SpA starting secukinumab or a TNFi 2015 through 2018 were identified in the Swedish Rheumatology Quality Register. Occurrence
divided the data set temporally, assessing the persistence of identified subgroups over different periods. The reassessment of mortality risk used the targeted maximum likelihood estimation (TMLE) method to achieve more robust causal modeling. Results: We analyzed data from 21,005 children. The mortality risk (6 weeks to 3 years of age) was 5.2% (95% CI 4.8%-5.6%) for children born between 2003 an
The advancement of mobile technologies and their ability to utilize the Global Positioning System (GPS) to accurately locate their substantial number of users, prompt Location-Based Services (LBS) significantly. Ride-sharing is a popular means of transportation that utilizes LBS. With the rapid development of smart cities and their impact on addressing the critical issues of urban life such as tra
Climate change is expected to increase woody vegetation abundance in the Arctic, yet the magnitude, spatial pattern and pathways of change remain uncertain. We compared historical orthophotos photos (1952 and 1979) with high-resolution satellite imagery (2015) to examine six decades of change in abundance of white spruce Picea glauca and tall shrubs (Salix spp., Alnus spp.) near the Agashashok Riv
Operating enormous, integrated refineries and clusters, the petrochemical industry runs processes in which hydrocarbons are turned into the fundamental components for plastics and other synthetic materials. Continuing a historical trend of consistent output growth, petrochemicals are the largest current driver of oil demand growth. At the same time, the industry is under increasing pressure to tra
This thesis is composed of four papers, the first two show the attempts made to extend the Pythia event generator to simulate heavy-ion collision events. The other two papers show methods to improve the hadronization mechanism in the Pythia model for a bettter agreement with the experimental data of pp and heavy-ion collisions.Paper I introduces a new model named Angantyr for heavy-ion collision e
Highlights: Women predominantly exhibit HFpEF compared to men. Factors exclusive to women, such as adverse pregnancy outcomes and premature menopause, elevate the risk of HF. The establishment of sex-specific optimal drug dosages and concrete guidelines for device therapy is essential. Concerted multidisciplinary initiatives are crucial to bridge the existing sex disparities in HF management. Hear
Cardiometabolic diseases are the leading preventable causes of death in most geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic diseases vary greatly worldwide, as do the resources and strategies needed to prevent and treat them. Therefore, there is no single solution and health care should be optimised, if not to the individual (ie, personalised health care), the
Sustainable finance has become of great importance over the past years, especially due to global climate development, resulting in increased awareness among public and private sectors, and hence, more conscientious investors. In a market familiar with green bonds, Sustainability-Linked Bonds (SLBs) emerged as a new financial instrument posing a lesser greenwashing risk and, therefore, greater pote
Unsustainable use of natural resources has been the basis for economic growth since the industrial revolution. The linear model of extraction, processing, consumption and disposal has brought significant environmental consequences such as resource scarcity, pollution, biodiversity loss and climate change. The use of plastics is one example of unsustainable human behaviour. The use of them has offe
As we grapple with the existential threat of global climate change and biodiversity collapse, there is a growing recognition to address the ever-growing levels of consumption. There is an urgent need to clamp down on the excessive levels of lifestyle emissions fuelled by individuals in the developed world along with the growing middle class in the developing parts for us to have any chances of hav
During excavations, steel sheet piles are often installed through vibratory driving, to establish a retaining wall that resists soil instability and ground water leakage. The method of vibratory driving is that the sheet pile is driven into the soil with a vertical vibratory motion. This is especially effective in soft soils. In parts of Sweden, however, the most common type of soil is the glacial
Against the background of a conservative push against LGBTI+ and women’s rights, in which courts have already become battlefields, it is important to look at how the European Court of Human Rights, a leading human rights adjudicator both in Europe and globally, would respond to arguments made in the name of human rights but whose real purpose is to limit the rights and freedoms of women and LGBTI+
Bio-based plastics are increasingly considered as sustainable alternatives to fossil-based plastics. Up until now, their application in the food packaging industry has been limited. The purpose of this study is to investigate the applicability of bio-based polymer packaging films for bakery products, herbs and spices in the meal kit industry context and to assess their contribution towards a more
The Earth’s climate has always been changing, since the origin of our planet. The rate of change is now rapidly increasing in a substantial scale, leading to new challenges. The average temperature on Earth has risen 0.9 degrees since the 19th century and the oceans have absorbed a substantial amount of heat and carbon dioxide, believed leading to ocean acidification killing the marine life. Ice s
