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Background: Oropharyngeal cancer (OPC) is an important cause of cancer-related mortality. Early detection of OPC results in a favorable prognosis and higher survival rates. Infection by high-risk types of human papillomavirus (HPV) is a risk factor for OPC with an upward trend globally. Medical students' knowledge and awareness of HPV-related OPC can be crucial in the preventive efforts. Aim: To a
Background and purpose: Radiation therapy treatment planning is a manual, time-consuming task that might be accelerated using machine learning algorithms. In this study, we aimed to evaluate if a triplet-based deep learning model can predict volumetric modulated arc therapy (VMAT) dose distributions for prostate cancer patients. Materials and methods: A modified U-Net was trained on triplets, a co
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM
The advancement of mobile technologies and their ability to utilize the Global Positioning System (GPS) to accurately locate their substantial number of users, prompt Location-Based Services (LBS) significantly. Ride-sharing is a popular means of transportation that utilizes LBS. With the rapid development of smart cities and their impact on addressing the critical issues of urban life such as tra
Climate change is expected to increase woody vegetation abundance in the Arctic, yet the magnitude, spatial pattern and pathways of change remain uncertain. We compared historical orthophotos photos (1952 and 1979) with high-resolution satellite imagery (2015) to examine six decades of change in abundance of white spruce Picea glauca and tall shrubs (Salix spp., Alnus spp.) near the Agashashok Riv
Operating enormous, integrated refineries and clusters, the petrochemical industry runs processes in which hydrocarbons are turned into the fundamental components for plastics and other synthetic materials. Continuing a historical trend of consistent output growth, petrochemicals are the largest current driver of oil demand growth. At the same time, the industry is under increasing pressure to tra
Ammonia (NH3) emerges as a promising carbon-free fuel, necessitating an understanding of its fundamental combustion properties, particularly the laminar burning velocity (SL), at very high unburnt temperatures (Tu). Despite this need, a consensus on the relationship between SL and Tu across a broad temperature range has not yet been established. This study investigated the SL vs. Tu relationship f
Objectives: Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse events. Methods. We included 100 patients treated with intravenous belimumab. Clinical data and biologica
Herbicides are one of the most heavily applied groups of pesticides globally. Whilst research on herbicides in relation to bees is growing, we still have more to learn about how bees may interact with herbicides and the subsequent consequences for bee health. As herbicides are designed to kill the plants they are applied to, bees and other pollinators may interact with them in a different way to o
One of the main themes in modern Islamic debate has been the relationship between universal and cultural particularistic norms regulating human affairs, the sphere which in classical Islamic tradition is designated as mu´amalat. A recurrent topic of contest has been the universal character of international conventions on human rights. In this paper I will discuss two attempts at accommodation by
Popular Abstract in Swedish Vi använder allt mer energi och efterfrågan kommer bara öka, fram till 2050 spås en fördubbling av världens efterfrågan av energi. Drygt 85 procent av den energi som produceras i dag kommer från fossila bränslen som bidrar till växthuseffekten. En ny rapport från FN:s klimatpanel, IPCC, visar att koldioxid står för runt 76 procent av det totala utsläppet av växthusgasAccelerating actions to mitigate CO2 emissions was one of the important messages at the UN Climate Summit 2014. About 85 % of the world’s energy is provided through the burning of fossil fuels, which is the main source of CO2 emissions. Increasing the share of renewable energy, and making energy efficiency improvements and savings were actions that were agreed upon to meet CO2 emission reductions.
This thesis deals with Chiral Perturbation Theory (ChPT), an effective field theory for the strong force used to describe meson interactions. The work done can be split in two parts. The first one is on ChPT in its standard formulation. This theory has been very successful so far in describing low energetic processes. However, it is still not entirely clear how much it can be trusted for precision
Background: The WHO and the World Bank ask countries to report the national volume of surgery. This report describes these data for Sweden, a high-income country. Methods: In an 8-year population-based observational cohort study, all inpatient and outpatient care in the public and private sectors was detected in the Swedish National Patient Register and screened for the occurrence of surgery. The
Local governments’ limited mandate and capacity to adequately deal with increasing climate risk and impacts means that citizen engagement is becoming increasingly important for adapting to hazards such as floods and storms. Stronger collaborative approaches are urgently needed. At the same time, there is little research and hardly any empirical evidence on what inspires adaptation engagement in di
Extensively managed grasslands are recognized globally for their high biodiversity and their social and cultural values. However, their capacity to deliver multiple ecosystem services (ES) as parts of agricultural systems is surprisingly understudied compared to other production systems. We undertook a comprehensive overview of ES provided by natural and semi-natural grasslands, using southern Afr
Access to clean and affordable energy is one of the cornerstones of the world’s society. Sincethe introduction of the internal combustion engine, diesel engines have become widely usedfor transportation in the commercial sector. These engines are attractive as they have lowfuel consumption, but are also associated with high emissions of air pollutants, such asNOX and soot. These emissions are direAccess to clean and affordable energy is one of the cornerstones of the world's society. Since the introduction of the internal combustion engine, diesel engines have become widely used for transportation in the commercial sector. These engines are attractive as they have low fuel consumption, but are also associated with high emissions of air pollutants, such as NO$_X$ and soot. These emissions a
Simultaneously planar laser-induced fluorescence (PLIF) measurements of OH, CH, CH2O and toluene are carried out to investigate the structures of turbulent premixed methane/air jet flames in the flamelet regime and the thin-reaction zones regime. A premixed flame jet burner of an inner diameter of 1.5 mm is employed. Stoichiometric methane/air mixtures introduced as a jet are ignited and stabilize
On Earth, the deep subsurface biosphere of both the oceanic and the continental crust is well known for surviving harsh conditions and environments characterized by high temperatures, high pressures, extreme pHs, and the absence of sunlight. The microorganisms of the terrestrial deep biosphere have an excellent capacity for adapting to changing geochemistry, as the alteration of the crust proceeds
