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While the associations of mid-life cardiovascular risk factors with late-life white matter lesions (WMH) and cognitive decline have been established, the role of cerebral haemodynamics is unclear. We investigated the relation of late-life (69–71 years) arterial spin labelling (ASL) MRI-derived cerebral blood flow (CBF) with life-course cardiovascular risk factors (36–71 years) and late-life white
Humanity has long battled mosquitoes and the diseases they transmit—a struggle intensified by climate change and globalization, which have expanded mosquito ranges and the spread of associated diseases.1 Additionally, widespread insecticide resistance has reduced the efficacy of current control methods, necessitating new solutions.2,3 Nootkatone, a natural compound found in grapefruit, shows promi
An astonishing number of bat fatalities (2,371 belonging to 15 species) were recovered in a provincial surveillance program at wind farms in Cádiz, at the southern tip of Spain, in 2005–2016. We carefully analysed a subset of this sample intending to estimate the true fatality rate in the year 2011, the year for which we had the richest data set (582 fatalities at 38 wind farms). To estimate the t
Inconsistent reporting of outcomes in clinical trials of treatments for whiplash associated disorders (WAD) hinders effective data pooling and conclusions about treatment effectiveness. A multidisciplinary International Steering Committee recently recommended 6 core outcome domains: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life an
Popular Abstract in Undetermined The thesis is written within the project Strengthening Legal Education in Vietnam.Well-known trademarks have been recognized as one of the most important types of trademark in the trademark system as reflected in both national law and in international treaties. The legal regime of well-known trademark protection has been continuously enhanced and developed over time due to the increasing importance of well-known trademarks becoming known to a worldwide public as well as develop
Popular Abstract in English These days we hear a lot about sustainability and most of us try to live in a more sustainable way. We use less water and energy, we sort our household waste and we prefer to consume products that are produced with less negative human impact. However, when it comes to our own excreta we definitely think of it as waste. And we are glad enough that wastewater treatment syEutrophication or the nutrient enrichment of water bodies, typically by nitrogen and phosphorus has adversely affected the aquatic life and the quality of water. Governments have been forced to take actions in order to reduce the release of these nutrients into the environment. To date the main global effort has been to remove such nutrients at source. However, with an increase in awareness of the
The effects of possible climate changes on a cold attic performance are considered in this work. The hygro-thermal responses of the attic to different climate data conditions are simulated using a numerical model, which has been made using the IBPT. Cold attic, which is the most exposed part of the building to the environment, is classified as a risky construction in Sweden. Mould growth on intern
Background and aimImproving the quality of health care is a global priority, yet many conventional quality improvement approaches, rooted in industrial models of standardisation and control, struggle to account for the uncertainty and complexity of clinical care. Trauma, defined as external injury and the body's physiological response, causes about 4.4 million deaths each year. The impact is great
Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. At first approved for the treatment of type 2 diabetes mellitus, tirzepatide represents one of the latest clinically approved and commercia
The global extraction of minerals is commonly located in areas populated by indigenous people; and while conflicts between multinational corporations and local activists and indigenous people are widespread today, the understanding of their dynamics are lacking. The Swedish government’s encouragement to an expanding mining industry has caused resistance due to environmental and social implications
Bone marrow mesenchymal stromal cells (BM-MSCs) are a rare population of cells that gives rise to skeletal tissues and the hematopoietic stroma in vivo. Recently, we have demonstrated that BM-MSCs fulfill stringent in vivo stem cell criteria when propagated as non-adherent mesenspheres but not as adherent-cultured cells. Motivated by these profound functional differences, the current study aimed t
Background: Intimate partner violence against women (IPVAW) is a global and preventable public health problem. Public attitudes, such as victim-blaming, are important for our understanding of differences in the occurrence of IPVAW, as they contribute to its justification. In this paper, we focus on victim-blaming attitudes regarding IPVAW within the EU and we apply multilevel analyses to identify
IMPORTANCE Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. OBJECTIVE To investigate whether amyloid-β aggregation is associated with cognitive functioning in
Buildings are responsible for a third of global greenhouse gas emissions, with much of their life cycle impacts stemming from embodied impacts of building materials. Both at EU and Member State level, circular economy and resource efficiency policies are promoting production of lower-impact building materials with secondary material input. However, secondary material strategies do not result in ca
Technological development, in particular the development of information and communicatiion technologies (ICT), is often presented as the answer to many social problems. Proponents of the Information Society suggest that poverty, failing integration, unemployment, and llack of democracy can be addressed with the appropriate technological means. Inequality iis often framed in terms of a digital divi
Climate change has made urban decarbonisation a global imperative. Cities are both a source of emissions and a leverage-point for the necessary transformation processes. Iceland is blessed with an ample supply of renewable energy sources. Hydropower and geothermal are widespread in the country and they dominate the country’s electricity and district heating systems. Despite this huge potential, pe
An extensive body of research has shown that episodic remembering involves spontaneous eye movements that largely reproduce the gaze patterns that were present during encoding (e.g., Brandt & Stark, 1997; Johansson et al., 2012). Recent work has further shown that fixation locations that overlap between encoding and recall promote cortical episodic reconstruction (Bone et al., 2018; Johansson
