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In Europe, 6,000 young people die of cancer yearly, the commonest disease causing death beyond the age of 1 year. In addition, 300,000-500,000 European citizens are survivors of a childhood cancer and up to 30% of them have severe long-term sequelae of their treatment. Increasing both cure and quality of cure are the two goals of the European paediatric haematology/oncology community. SIOPE coordi
An integrated study of palynology, Mossbauer spectroscopy, mineralogy and osmium isotopes has led to the detection of the first K-Pg boundary clay layer in a Southern Hemisphere terrestrial setting. The K-Pg boundary layer was independently identified at centimetre resolution by all the above mentioned methods at the marine K-Pg boundary site of mid-Waipara and the terrestrial site of Compressor C
Constraining past changes in the strength and configuration of the geomagnetic field provides a valuable perspective on the processes that govern the geodynamo. Here we update a modelled dipole tilt reconstruction for the last 9000 years by using palaeomagnetic records that originate from globally well-distributed sites. Some features predicted by earlier dipole models become more distinct due to
Soil salinization is a growing threat to global agriculture and carbon (C) sequestration, but to date it remains unclear how microbial processes will respond. We studied the acute response to salt exposure of a range of anabolic and catabolic microbial processes, including bacterial (leucine incorporation) and fungal (acetate incorporation into ergosterol) growth rates, respiration and gross N min
Widespread negative correlations between summertime-mean temperatures and precipitation over land regions are a well-known feature of terrestrial climate. This behavior has generally been interpreted in the context of soil moisture atmosphere coupling, with soil moisture deficits associated with reduced rainfall leading to enhanced surface sensible heating and higher surface temperature. The prese
Identification of breeding sites remains a critical step in species conservation, particularly in procellariiform seabirds whose threat status is of global concern. We designed and conducted an integrative radiotelemetry approach to uncover the breeding grounds of the critically endangered New Zealand Storm Petrel Fregetta maoriana (NZSP), a species considered extinct before its rediscovery in 200
The effects of possible climate changes on a cold attic performance are considered in this work. The hygro-thermal responses of the attic to different climate data conditions are simulated using a numerical model, which has been made using the IBPT. Cold attic, which is the most exposed part of the building to the environment, is classified as a risky construction in Sweden. Mould growth on intern
The rise of antibiotic-resistant soil microbial communities is a critical global issue. Evidence suggests that heavy metals can select or co-select for tolerance to metals and antibiotics in soil bacteria, but it is unclear if this tolerance varies with land use. We tested the potential of bacterial communities to develop resistance to copper (Cu) or tetracycline (Tet) after amending soils from pr
In the last decade, more than 22 million ha of land have been contracted to large-scale land acquisitions in Africa, leading to increased pressures, competition, and conflicts over freshwater resources. Currently, 3% of contracted land is in production, for which we model site-specific water demands to indicate where freshwater appropriation might pose high socioenvironmental challenges. We use th
What takes place during the monitoring cycles of UN treaty bodies, and what impact do these cycles have both locally and globally? Movement in the Rights Direction explores these questions through the lens of the UN Human Rights Committee, the treaty body responsible for overseeing state compliance with the International Covenant on Civil and Political Rights (ICCPR), often considered the UN’s mos
Background and ObjectivesThe number of older adults living alone is increasing globally, often with varied risks and resilience capacities. Digital technologies may help mitigate these risks, but their potential remains poorly understood. This review maps evidence on digital technologies in social and health care interventions for older adults living alone, focusing on technology types, functions,
In order to preserve the variety of life on Earth, we must understand it better. Biodiversity research is at a pivotal point with research projects generating data at an ever increasing rate. Structuring, aggregating, linking and processing these data in a meaningful way is a major challenge. The systematic application of information management and engineering technologies in the study of biodiver
BACKGROUND: Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Because of reported health risks, diisononyl phthalate (DiNP) has been introduced as a replacement for di(2-ethylhexyl) phthalate (DEHP) in soft PVC. This raises concerns because animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP. The a
The predicted global warming may affect freshwater systems at several organizational levels, from organism to ecosystem. Specifically, in temperate regions, the projected increase of winter temperatures may have important effects on the over-winter biology of a range of organisms and especially for fish and other ectothermic animals. However, temperature effects on organisms may be directed strong
Objectives To develop a score for assessment of patients' symptoms in primary Sjogren's syndrome (SS): the EULAR SS Patient Reported Index (ESSPRI). Methods Dryness, pain, somatic and mental fatigue were identified as the main symptoms of patients with primary SS, in studies developing the Profile of Fatigue and Discomfort (PROFAD) and Sicca Symptoms Inventory (SSI). It was suspected that a single
In these times, when global warming is escalating and the finite resources of the world are consumed in a fast pace, it is very important to find sustainable solutions for the near future. Transport is one of the sectors that need to find alternative solutions to the utilisation of fossil fuels. This master thesis investigates biogas production from ley crops, which is a mixture of different speci
Sustainable development “which meets the needs of the present without compromising the ability of future generations to meet their own needs,” (WCED 1987) is a global development objective of paramount importance. However, on the ground, ‘sustainable development’ is – in my experience – often little more than a buzzword for securing grants. From a strong sus-tainability standpoint, this thesis doc
Popular Abstract in Swedish Septisk shock (shock utlöst av blodförgiftning) är en potentiellt dödlig komplikation till infektion med bakterier eller andra mikroorganismer. Inte bara de infekterande organismerna i sig, men också de inflammatoriska system och signalsubstanser som aktiveras, orsaker ett generaliserat inflammatoriskt tillstånd. Om obehandlat, kan detta leda till att ett eller flera orNitric oxide (NO) is important in the control of blood pressure and organ perfusion. In septic shock, NO produced by inducible NO-synthase (NOS) has been claimed to mediate pathological vasodilation and cell injury, while NO produced by constitutive NOS may be protective in counteracting hypoperfusion and organ injury. This thesis comprises studies on the effects of inhaled NO on pulmonary functio
