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Background: The immune checkpoint receptor lymphocyte-activation gene 3 (LAG3) is a new target for immune checkpoint blockade (ICB), but the effects of LAG3 on atherosclerosis are not known. Objectives: The aim of the study was to evaluate the role of LAG3 on plaque inflammation using murine hypercholesterolemic models of atherosclerosis. Methods: To study the role of LAG3 in atherosclerosis, we i
Molybdenum clusters, characterized by their unique structure and intriguing catalytic properties, have gained significant attention in recent years. In several existing studies, density functional theory (DFT) methods have been used to find the lowest energy Mo clusters and explore their electronic and magnetic structure. In all cases, with the exception of a single recent study, where a genetic a
Background: The global incidence of stroke is on the rise, primarily due to an increase in the aging population and the prevalence of vascular risk factors among the elderly. However, stroke is a treatable condition if promptly recognized and managed effectively. To optimize stroke management, it is crucial to establish a well-prepared infrastructure comprising adequately trained physicians workin
IMPORTANCE AND AIMS: Diabetic microvascular complications significantly impact morbidity and mortality. This review focuses on machine learning/artificial intelligence (ML/AI) in predicting diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic neuropathy (DN).METHODS: A comprehensive PubMed search from 1990 to 2023 identified studies on ML/AI models for diabetic microvascular comp
Around the world, paid work without appropriate structural support is a key barrier to optimal breastfeeding practices. To better protect, promote, and support optimal breastfeeding practices among working women in Africa, this scoping review sought to understand how paid work influences infant feeding practices in the first 6 mo of life and what support women need to manage work and optimal infan
Background: Musculoskeletal disorders (MSK) are a global burden causing significant suffering and economic impact. Systematic identification and targeting of research questions of highest interest for stakeholders can aid in improving MSK disorder knowledge and management. Objective: To obtain Swedish MSK researchers' opinions and views on a collaborative Swedish MSK network (SweMSK) and identify
OBJECTIVE: Traumatic brain injury is a major global public health problem for which specific therapeutic interventions are lacking. There is, therefore, a pressing need to identify innovative pathomechanism-based effective therapies for this condition. Thrombus formation in the cerebral microcirculation has been proposed to contribute to secondary brain damage by causing pericontusional ischemia,
The Corporate Sustainability Reporting Directive (CSRD) transitions sustainability reporting from voluntary to mandatory, aiming to enhance transparency and improve sustainability practices. A new demand from the directive is that companies need to report information on their supply chain, ensuring cooperation throughout supply chains as essential for implementing the CSRD effectively while mainta
The construction sector accounts for a significant portion of Sweden's total greenhouse gas emissions and is a contributing factor to several other current environmental issues. Given this, demolitions are problematic from an environmental perspective. The aim of this study is to examine demolition permits granted within the City of Stockholm and assess the associated climate impact. The resea
The building sector uses about 40% of the total global energy use. Sweden aims to reach its new goal to reduce the energy use in their residential sector as well as commercial sector by 20%, which should be reached by year 2020 and 50% by year 2050. To find a solution to this problem European Union (EU) collaborated with IVL (Swedish environmental Research Institute) and LKF (lunds Kommuns Fastigh
This thesis investigates the role of sense of place narratives in the scaling of conflicts, using the Israel-Gaza conflict as a critical case study. Existing literature has extensively discussed scale framing and the significance of scale in conflict resolution but has not fully explored the mechanisms through which the scaling of conflicts occurs. The study aims to address this gap by proposing a
With increasing country-level gender equality, country-level gender differences in personality are found to increase. This is known as the Gender-Equality-Personality-Paradox (GEPP). Possibly, the GEPP is a methodological artefact. So far, the personality trait scoring method has not been investigated as a potential source of the GEPP. Three kinds of scores were investigated in the present study:
Poly(vinyl chloride) has a long history of use in the flooring industry. Throughout the years, several environmental and health issues have arisen concerning the production, usage and disposal of PVC. Forbo Flooring Systems is a company striving to provide environmentally friendly products for their customers, and therefore has an investigation of alternative polymers to PVC been initiated. The ai
Plastic pollution is a severe global problem and every year approximately 368 million tons of plastic is produced. Both terrestrial and marine environments are impacted and hundreds of species affected. Marine plastic debris accounts for a weight of 268 940 tons and affects hundreds of marine species through habitat degradation, entanglement and ingestion. Microplastics (MPs) are a type of plastic
The thesis aims at supplementing a critique of the existing international instruments, regional responses and national legislation of the Arctic related to marine environmental protection. With this aim in view, the thesis satisfies its objective by proposing a Bipartite “Arctic Council” acting as a conglomeration of the Arctic States and the Flag States with a hybrid “Arctic treaty”, which is an
The start-up company LEVTEK is launching a new ultralight electric utility vehicle called the LEVKART. The Levkart uses a combination of robotics and AI-technology to offer semi-autonomous or autonomous riding and usage. The purpose of the vehicle is to serve as an alternative to cargo bikes and electric scooters designed for easy usage and as a more sustainable option to fossil-based transport. T
