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Variations in laser properties and data acquisition times introduced inconsistencies in Geoscience Laser Altimeter System (GLAS) data. The effect of data inconsistencies, on two GLAS height retrieval methods, from three study sites, are investigated and validated against airborne laser scanning (ALS) percentile heights, from three data sources: all/first return point clouds, and raster canopy heig
Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo using cerebrospinal fluid (CSF). We investigated the aggregation mechanism of Aβ42 in human CSF thro
The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised of experts across many fields, including genomics, data analysis, engineering, public health, and architecture. The ultimate goal of the MetaSUB Consortium is to improve city utilization and planning through the detection, measurement, and design of
There is extensive duplication of accessions among collection holders globally. To save costs, unwanted duplication should be avoided. This issue has been addressed internationally. In Europe, there are currently 35 Brassica collections located in 24 countries. Duplication may be identified not only by surveying passport data and seed transactions, but also by applying morphological or genetic cha
Definitive hematopoiesis emerges via an endothelial-to-hematopoietic transition in the embryo and placenta; however, the precursor cells to hemogenic endothelium are not defined phenotypically. We previously demonstrated that the induction of hematopoietic progenitors from fibroblasts progresses through hemogenic precursors that are Prom1+Sca1+CD34+CD45- (PS34CD45-). Guided by these studies, we an
Many signals must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. However, the exact molecular regulatory mechanisms remain elusive. To unravel the essential internal and external signals required for sustaining the ESC state, we conducted a short hairpin (sh) RNA screen of 104 ESC-associated p
Ultrafast transient absorption spectroscopy and single-wavelength anisotropy measurements were used to study the effect of isomerization on the excited-state properties of fucoxanthin in polar and nonpolar solvents. The excitation wavelengths were 477 nm for all-trans-fucoxanthin, and 333 and 477 nm for cis-fucoxanthin. All transient absorption spectra of the fucoxanthin isomers in polar solvents
Popular Abstract in Swedish BAKGRUND Fokus riktas allt mer mot försörjningskedjan och allt mindre mot det enskilda företaget i takt med att konkurrens mellan enskilda företag ersätts av konkurrens mellan försörjningskedjor. Det är emellertid endast det enskilda företaget som kan fatta beslut och vidta åtgärder, men dessa beslut och åtgärder måste idag ske utifrån ett kedjeperspektiv. Med ökat foBackground Today's modern, industrialized society is based on globalization, specialization and mass-production. It is a society dependent upon highly integrated, continuously ongoing supply chain flows. Disruptions in those flows may cause devastating negative consequences, both for the individual company, for the supply chain, and for the society at large. Purpose and objectives The purpose o
In the global market of air transport, integration of products and services is now seen as being necessary for the long-term success of engine manufacturers. This paper describes research stimulated by a fundamental shift that is occurring in the manufacture and marketing of aero engines for commercial and defence purposes, away from the selling of products to the provision of services. Our collab
The implementation of sustainability in the construction sector depends to varying extents at global, national, regional, local, corporate and individual levels. In addition, it appears to be a lack of knowledge transfer to local construction project management according to managing the process towards sustainability. Accordantly to environmental legislation, it is the client that is the responsib
Spin-polarized calculations in solids have generally been confined to a global quantization axis to simplify both the theoretical model and its implementation in self-consistent codes. This approximation is justified as many materials exhibit a collinear magnetic order. However, in recent years much interest has been directed towards noncollinear magnetism in which the magnetization density is a c
BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD
Study objectives: We examined and compared cross-sectional and longitudinal associations between self-reported sleep disturbances and various cognitive domains in five separate Nordic European longitudinal aging studies (baseline N = 5631, mean age = 77.7, mean follow-up = 4.16 years).Methods: Comparable sleep parameters across studies included reduced sleep duration/quality, insomnia symptoms (sl
Agriculture is key to sustainable development globally – particularly incountries where agriculture both accounts for most of the land use andprovides a livelihood for most of the population. We map out a collaborativeresearch agenda aimed at tackling the urgent but poorly understood issue ofthe role of farmer organisations in overcoming political barriers tosustainable and inclusive agricultural
Diagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood-based biomarkers (BBMs) for AD holds promise in enabling early detection of pathology and timely intervention. However, several critical considerations, such as the lack of consistent guidelines for assessing cognition, limited un
Despite a growing body of research on the role of the Sustainable Development Goals (SDGs) at the local level, knowledge on how they are taken up in local governance processes remains limited. This article contributes to knowledge on SDG implementation by examining how the SDGs can contribute to governance change at the local level. We develop a process-oriented analytical framework that examines
BACKGROUND: The transition to undertaking rehabilitation in the home or local neighbourhood calls for an extensive understanding of which aspects of the built environment are important for people with stroke.OBJECTIVE: This qualitative study aims to explore how home and local neighbourhood environments support or hinder rehabilitation for people who have had a stroke from the perspectives of vario
Plastic waste has come to the forefront of academic and political debates as a global problem that demands an urgent solution. Promoted by policymakers, academia, and corporations alike, the circular economy model presents a viable path to reach more sustainable levels of development. Emerging and disruptive technologies can catalyse the transition to a circular economy, but their application to t
