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Mitochondrial components dynamically change in response to environmental and developmental cues. However, the regulatory pathways that underlie these changes are largely unknown. A global analysis of changes in mitochondrial components at the transcript, protein and metabolite levels was undertaken, to gain a greater insight into how mitochondrial functions are regulated and respond to various int
Cardiopulmonary resuscitation is started in 5000 victims of out-of-hospital cardiac arrest in Sweden each year and the survival rate is approximately 10%. The subsequent development of a global ischaemic brain injury is the major determinant of the neurological prognosis for those patients who reach the hospital alive. Induced hypothermia is a recommended treatment after cardiac arrest and has bee
Scholars have argued that we have compelling reasons to combat climate change because it threatens human rights, referred to here as ‘climate rights’. The prospects of climate rights are analysed assuming two basic desiderata: its accuracy in capturing the normative dimension of climate change (reasons to prevent/mitigate/adapt to climate change); and its ability to generate political measures. In
We consider a broad class of stochastic imitation dynamics over networks, encompassing several well known learning models such as the replicator dynamics. In the considered models, players have no global information about the game structure: they only know their own current utility and the one of neighbor players contacted through pairwise interactions in a network. In response to this information
This article draws attention to storytelling in public diplomacy. Based on interviews with officials in the European External Action Service (EEAS) and a campaign on social media, it explores storytelling in EU public diplomacy. It treats storytell-ing as narrative strategies that tap into the power of dramaturgy and visual elements to mediate emotions and identity in international politics. This
This paper discusses the COVID-19 pandemic as an opportunity to reconsider the foundations of the global aviation system. There is much evidence that air transport creates opportunities as well as risks. While the former accrue to businesses and individuals, risks are imposed on society. Pandemics, in which aviation has a role as a vector of pathogen distribution, as well as the sector's contribut
Introduction Longer travel times are associated with increased adverse maternal and perinatal outcomes. Geospatial modelling has been increasingly used to estimate geographic proximity in emergency obstetric care. In this study, we aimed to assess the correlation between modelled and patient-reported travel times and to evaluate its clinical relevance. Methods Women who delivered by caesarean sect
We are at a time when international law and the law of war are particularly important. The testing of nuclear weapons that is being used in the rhetoric surrounding threats of war is creating new fears and heightening current tensions. Richard Falk has for decades been an outspoken authority calling for nuclear disarmament and the enforcement of non-proliferation treaties. In this collection of es
Farmers as volunteers in research could potentially provide a rich resource for exploring sustainable agricultural research questions. To discern emerging patterns in citizen science-based studies on topics with relevance for sustainable agriculture, and reveal salient challenges and opportunities for conducting such studies, we conducted a systematic literature review of 27 peer-reviewed articles
Atmospheric nitrogen (N) deposition, an important component in the global N cycle, has increased sharply in recent decades in China. Here, we constructed national-scale inorganic N wet deposition (N dep) patterns in China based on data from 280 observational sites and analysed the effects of anthropogenic sources and precipitation on N dep. Our results showed that the mean N dep over China increas
The global public health problem of intimate partner violence against women (IPVAW) is typically tied to gender inequality. Contrary to what would be expected, however, a 2012 survey conducted by the European Union Agency for Fundamental Rights (FRA) showed lifetime prevalence rates of IPVAW in the Nordic countries which were among the highest of the 28 EU member states, despite these countries be
Migration represents a major transformation of the lives of those involved and has been transformative of societies and economies globally. Yet models of sustainability transformations do not effectively incorporate the movement of populations. There is an apparent migration-sustainability paradox: migration plays a role as a driver of unsustainability as part of economic globalisation, yet simult
Mainstreaming is a popular approach when seeking to address societal inequalities. Gender and migrant integration are mainstreamed within EU policy, both seeking to increase labour market participation as a means to redress inequality. However, there are limited references to migrant women within gender equality or integration policies at the EU level. The study dissects a subset of migrant integr
Biomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in the clinic but also to facilitate the development and monitoring of effective disease-modifying therapies. Positron emission tomography methods detecting amyloid-β and tau pathology in Alzheimer’s disease have been increasingly used to improve the design of clinical trials and observational studies. In recent
While there is much debate on transformative change among academics and policymakers, the discussion on how to govern such change is still in its infancy. This article argues that transformative governance is needed to enable the transformative change necessary for achieving global sustainability goals. Based on a literature review, the article unpacks this concept of transformative governance. It
Caffeine is a widely consumed psychoactive substance, but little is known about the effects of caffeine stimulation on global gene expression changes in neurons. Here, we conducted gene expression profiling of human neuroepithelial stem cell-derived neurons, stimulated with normal consumption levels of caffeine (3 μM and 10 μM), over a period of 9 h. We found dosage-dependent activation of immedia
To appropriately switch between sessile and motile lifestyles, bacteria control expression of biofilm-associated genes through multiple regulatory elements. In Pseudomonas aeruginosa, the post-transcriptional regulator RsmA has been implicated in the control of various genes including those related to biofilms, but much of the evidence for these links is limited to transcriptomic and phenotypic st
The location of the West African craton (WAC) has been poorly constrained in the Paleoproterozoic–Mesoproterozoic supercontinent Nuna (also known as Columbia). Previous Nuna reconstruction models suggested that the WAC was connected to Amazonia in a way similar to their relative position in Gondwana. By an integrated paleomagnetic and geochronological study of the Proterozoic mafic dikes in the An
