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Climate change is altering aquatic environments in a complex way, and simultaneous shifts in many properties will drive evolutionary responses in primary producers at the base of both freshwater and marine ecosystems. So far, evolutionary studies have shown how changes in environmental drivers, either alone or in pairs, affect the evolution of growth and other traits in primary producers. Here, we
Candida albicans is a commensal fungus that causes systemic infections in immunosuppressed patients. In order to deal with the changing environment during commensalism or infection, C. albicans must reprogram its proteome. Characterizing the stress-induced changes in the proteome that C. albicans uses to survive should be very useful in the development of new antifungal drugs. We studied the C. al
Libraries of things, non-for-profit physical spaces where people borrow objects they would otherwise buy, have spread over Europe, the U.S., and Canada and have now emerged in Mexico City, where challenges to sustainability such as increased consumption levels and insufficient waste management abound. Collaborative economy initiatives like libraries of things are exposed as more sustainable altern
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of Aβ, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related Aβ-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstr
Recent global warming trends, particularly in the arctic regions and Himalayas are modifying forest structure and function, notably biogeographical changes in tree species distribution together with alteration in Net Primary Production (NPP), Leaf Area Index (LAI) and Carbon biomass. These alterations are most pronounced in mountain environments, carrying significant impacts on woody species which
Dagens samhälle står inför en stor klimatutmaning vilket ställer höga krav på alla branscher, inte minst bygg- och fastighetsbranschen. Byggnader och lokaler står idag för en tredjedel av Sveriges energianvändningen där 60 % går till uppvärmning. För att minska utsläppen från bostäder och lokaler har stort fokus lagts på byggnaders energianvändning under dess driftsfas. I takt med att byggnader blThe society is today facing a major climate challenge, which places high demands on all industries, not least the construction and real estate industry. Buildings are today accounting for one third of Sweden's energy use, of which 60 % is used for heating. In order to reduce emissions from buildings, great focus has been placed on the energy use of buildings during its operating phase. As buil
Popular Abstract in Swedish Livskvalitet, motivation och kostnader vid rehabilitering av patienter med långvariga muskuloskeletala besvär Långvariga muskuloskeletala besvär är ett omfattande medicinskt, socialt och ekonomiskt problem i utvecklade länder. Syftet med avhandlingen var att utvärdera ett multidisciplinärt rehabiliteringsprogram som fokuserade på Basal Kroppskännedom och kognitiv och Prolonged musculoskeletal disorders (PMSD) is an escalating medical, social and cost problem in developed countries. The complexity of PMSDs has emphasised the need of developing effective multidisciplinary rehabilitation programme with a holistic approach. The aim of the thesis was to evaluate the outcome of a multidisciplinary rehabilitation programme focusing on Body Awareness Therapy and cogn
Introduction: Although Alzheimer’s disease (AD) is associated with early death, its life expectancy differs greatly between patients. A better understanding of this heterogeneity may reveal important disease mechanisms underlying the malignancy of AD. The aim of this study was to examine the relation between AD pathologies and early death in AD caused by dementia. Methods: At a memory clinic, 247
Binding of calcium to the protein calmodulin leads to molecular reorganization that enables interaction with target peptides and activation of downstream processes. I have studied the dynamics of the calcium-loaded form of a C-terminal calmodulin mutant (E140Q-Tr2C) using NMR spin relaxation experiments. E140Q-Tr2C exhibits global conformational exchange on the microsecond time-scale. The populati
Process-based models can be classified into: (a) terrestrial biogeochemical models (TBMs), which simulate fluxes of carbon, water and nitrogen coupled within terrestrial ecosystems, and (b) dynamic global vegetation models (DGVMs), which further couple these processes interactively with changes in slow ecosystem processes depending on resource competition, establishment, growth and mortality of di
Background: Mental health problems are an increasing challenge for primary healthcare. It puts strain on the healthcare professionals with limited time and resources. In several countries, healthcare professionals can refer patients with mental health issues to structured arts programmes, namely Arts on Prescription (AoP). This study explores the qualitative findings from a 3-year study on Arts on
BACKGROUND AND OBJECTIVES: Tau accumulation pattern shows substantial variability in Alzheimer disease (AD), and 4 distinct spatiotemporal trajectories were distinguished using a data-driven approach called the Subtype and Stage Inference (SuStaIn). A visual method to validate and identify these subtypes is a requirement for their clinical translation. Our study aimed to provide a standardized top
Global warming and its effects on climate are of great concern. Climate change can affect buildings in different ways, i.e. it can change the energy demand or the moisture durability of buildings in the future. In Sweden, most of the last 20 years have been mild and wet compared to the 1961-1990 climate reference period. Future needs and risks of the building sector depend on the future climate wh
Aims: Social science literature suggests that unlimited trust in others may lead to adverse outcomes, and that moderate trust may be more optimal in social interactions. The aim was to analyze associations between generalized trust in other people and all-cause mortality using a four-alternative generalized trust item that includes moderate trust. Study design: Prospective cohort study. Methods: T
Background: Studies on risk factors for severe COVID-19 in people of working age have generally not included non-working persons or established population attributable fractions (PAFs) for occupational and other factors. Objectives: We describe the effect of job-related, sociodemographic, and other exposures on the incidence, relative risks and PAFs of severe COVID-19 in individuals aged 18–64. Me
Popular science summary: Potential Distribution for the Endangered Asian Wild Ass Over the past century, large mammals have been globally under increasing pressure of humanized landscapes. Since extirpations of large herbivores are likely to have complicated consequences for the entire ecosystem, their conservation is a priority. With almost 81% threatened species, Perissodactyla (odd-toad ungu
Disturbances such as wildfires are key players involved in the shape, structure and function of the ecosystems. Fire is rarely included in Dynamic global vegetation models due to their difficulty in implementing its processes and impacts associated. Therefore, it is essential to understand the variables and processes involved in fire, and to evaluate the strengths and weaknesses before going forwa
The focus of this work is to investigate and apply the remote sensing method of object-based image analysis (OBIA) for vegetation classification of a permafrost underlain peatland in sub-arctic Sweden, by using aerial imagery of high resolution. Since the northern landscapes are an important source of naturally stored CH4 and CO2, their contribution to the global carbon cycle is a focus in researc
