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Popular Abstract in Swedish Mesenkymala stamceller (MSC) kan isoleras från en rad olika vävnader i kroppen, bland annat från benmärg. De kan differentiera till ben, brosk, fett- och bindvävnad men deras exakt roll i kroppen är inte väl känd. Den senaste forskningen tyder dock på att en av deras huvuduppgifter är att stödja blodbildningen som sker av blod- eller hematopoetiska stamceller. Man Primary mesenchymal stem cells (MSC) play a central role in bone marrow (BM) and during haematopoiesis. Yet, the exact phenotype and spatial distribution of primary MSC in the human BM are unknown. Their cultured progeny are promising candidates for clinical applications. MSC cultures however, are heterogeneous and, while critical for clinical applications, their exact composition is not known. W

We hypothesize that cerebral ischemia leads to enhanced expression of endothelin (ET), 5-hydroxytryptamine (5-HT), and angiotensin II (ANG II) receptors in the vascular smooth muscle cells. Our aim is to correlate the upregulation of cerebrovascular receptors and the underlying molecular mechanisms with the reduction in regional and global cerebral blood flow (CBF) after subarachnoid hemorrhage (S

Metalloenzymes are proteins that contain one or more metal ions bound to protein. They constitute about one-third of all enzymes known so far and they often perform hard chemical reactions involving small substrates, like H2 and N2. In our research, we focus on those metal ions that are located in the active sites and perform redox reactions, i.e. involving electron transfer. Why enzymes?Metalloenzymes catalyse a wide variety of reactions in nature. In the thesis, I have studied the reaction mechanism of three metalloenzymes, viz. [NiFe] hydrogenase (H2ase), dimethyl sulfoxide reductase (DMSOR) and formate dehydrogenase (FDH), by theoretical methods, namely quantum mechanics (QM), combined quantum mechanical and molecular mechanics (QM/MM), as well as QM/MM thermodynamic cycle per

Mild cognitive impairment in Parkinson's disease is associated with progression to dementia (Parkinson's disease dementia) in a majority of patients. Determining structural imaging biomarkers associated with prodromal Parkinson's disease dementia may allow for the earlier identification of those at risk, and allow for targeted disease modifying therapies. One hundred and five non-demented subjects

Great hopes have been placed in the sharing economy to provide a new business model based on peer-to-peer (P2P) exchanges of underutilized assets. As a model, the sharing economy has been expected to make significant contributions to sustainability, providing new opportunities for entrepreneurship, more sustainable use of resources, and consumer co-operation in tight economic networks. However, in

With Paul Wolfowitz now heading the World Bank, fighting corruption has become a top priority, with the Bank actually holding back funds to various countries due to corruption. USAID has also allocated hundreds of millions of dollars to anticorruption and governance. At the same time, there exist grassroots anticorruption initiatives, many of whom are linked to the international NGO Transparency I

Popular Abstract in Swedish Svensk sammanfattning Slaganfall (stroke), hjärtstillestånd eller överdosering av insulin är tillstånd som leder till en minskning av syre- och/eller glukos till hjärnvävnaden. Då tillförseln av glukos och syrgas minskar, kan cellerna inte längre upprätthålla en normal energiproduktion. Eftersom en stor del av energin går åt till bevara den spänning som finns över cellIn this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. The influence of bioenergetic failure on K+e concentration and Ca2+e homeostasis were also investigated in transient focal ischemia. Moreover, the free radical formati

To enter new markets is not easy. The most obvious challenge, at least judging from the majority of literature on internationalization, is to understand the new market thus taking a market(ing) perspective. External aspects of internationalization are often stressed, while internal aspects, focusing on why organizations fail, are less developed or examined. In order to better understand the intern

Popular Abstract in Swedish Ett material som utsätts för varierande last, även under gränslasten för statisk kollaps, riskerar att utveckla sprickor som i sin tur kan orsaka brott. Denna typ av materialnedbrytning kallas utmattning och är ett ständigt aktuellt forskningsområde. Väldigt korta sprickor är kända för att växa på ett sätt som avviker från hur längre utmattningssprickor beter sig, ävenThe growth of short fatigue cracks deviates from the behaviour of long fatigue cracks even if subjected to the same nominal driving force. The influence from the microstructure is pronounced, while crack closure effects may not be that important as for longer cracks. The objective of this thesis is to study the local conditions for crack growth for two different short crack problems, and to develo

Popular Abstract in Swedish Efterfrågan på shikimsyra, vilken återfinns i biosyntesvägen för bl.a. de aromatiska aminosyrorna tryptofan, fenylalanin och tyrosin, har under de senare åren ökat. Orsaken till detta är mestadels att den är råmatrial till antiinfluensamedicinen Tamiflu?. Den ökade efterfrågan har drivit fram nya tillverkningsmetoder såsom produktion via E.coli- fermentation. Även om maShikimic acid production using recombinant E.coli has been developed during the past 15 years due to the increased demand of this product, primarily as a starting material for the anti-influensa medicine Tamiflu?. A detailed metabolic analysis of a shikimic acid producing E.coli strain was made in the current work in order to increase the understanding of shikimic acid production and identify mean

We study transportation networks controlled by dynamical feedback tolls. We consider a multiscale transportation network model whereby the dynamics of the traffic flows are intertwined with those of the drivers' route choices. The latter are influenced by the congestion status on the whole network as well as dynamic tolls set by the system operator. Our main result shows that a broad class of dece

Study region: The Tibetan Plateau (TP) is a high-altitude region characterized by harsh environmental conditions and limited accessibility, making the monitoring of its numerous lakes a significant challenge. This region is crucial for hydrological studies, and its numerous lakes play an important role in regional water dynamics and climate change research. Study focus: This study evaluates the ap

In this special session we wish to critique and reimagine the anthropocentric present. In contemporary consumerist society (Schmitt et al., 2022), the global “free market” is presented as the solution to the environmental and climate urgency through pillars like unlimited growth, responsibilized consumers, and not least, the domination of Nature (e.g. Hornborg 2019). There are alternatives, but thIn this special session we wish to critique and reimagine the anthropocentric present. In contemporary consumerist society (Schmitt et al., 2022), the global “free market” is presented as the solution to the environmental and climate urgency through pillars like unlimited growth, responsibilized consumers, and not least, the domination of Nature (e.g. Hornborg 2019). There are alternatives, but th

National greenhouse gas inventories (GHGIs) are submitted annually to the United Nations Framework Convention on Climate Change (UNFCCC). They are estimated in compliance with Intergovernmental Panel on Climate Change (IPCC) methodological guidance using activity data, emission factors and facility-level measurements. For some sources, the outputs from these calculations are very uncertain. Invers

Climate change has diverse effects on the planet’s environment, including changes and shifts in the distribution and abundance of species. In this paper, we present a robust prediction ensemble algorithm for the current and future species distribution of Aegilops tauschii. Four modeling approaches were trained using various environmental variables (bioclimatic and soil variables) to accurately pre

The purpose of this thesis is to examine the United States’ influence on the international community’s ability to prohibit the Rwandan genocide of 1994. Over the course of 100 days government forces and Hutu militia implemented an elimination campaign with the main objective of ethnically cleansing Rwanda of the Tutsi minority, and effectively slaughtered 800,000 civilians. By rhetorically analyzi