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Rapporter visar att det sker en ökning bland sjukskrivningar på grund av stressrelaterade sjukdomar, främst bland yngre. Stress orsakas av att man har en obalans mellan sina aktiviteter och denna aktivitetsobalans är en stor riskfaktor för ohälsa. Arbetsterapeuter har som mål att skapa aktivitetsbalans och de har en viktig roll i rehabiliteringen av patienter som upplever aktivitetsobalans orsakad
Syfte: Syftet med denna studie är att undersöka vilka faktorer vid företagens börsintroduktioner, på NASDAQ OMX Stockholm och NGM Equity under åren 2001-2008, som påverkar sannolikheten att en efterföljande nyemission inträffar inom en kort tidsperiod (tre år). Metod: Studien är en kvantitativ undersökning där faktorer vid företagens IPO påverkar sannolikheten att en efterföljande SEO inträffar i
Changing people's attitude towards fire safety is the most important goal in this research. Looking closely how the fire safety education effects the peoples response in unannounced evacuation drill was the aim of the study. Constant changes in the process of the training made the improvements possible and weaknesses were identified. The staffs' attitude towards fire safety changed to the
Oxidativ stress i celler är en bakomliggande faktor till många dödliga sjukdomar. Detta kan kroppen reglera till en viss del med olika proteiner. Ett av proteinerna är Alfa-1-mikroglobulin (A1M) som kan sänka oxidativ stress i kroppen genom att t.ex binda till fria radikaler och bidra till vävnadsreperation. A1M transkriberas tillsammans med ett annat protein, bikunin, som har anti-inflammatoriska
Digitalisering inom högre utbildning är ett länge pågående projekt som fått sig en upptrappning under Covid-19-pandemin. Lärosäten världen över fick snabbt anpassa sig och ställa om till onlineundervisning för att skydda folkhälsan. Efter perioden av påtvingad onlineundervisning har högskolor och universitet mestadels återgått till campus-undervisning med en fortsatt strategi för digitalisering avDigitalization in higher education is a long-running project that has escalated during the Covid- 19 pandemic. Higher education institutions around the world had to adapt quickly and switch to online teaching to protect the public health. After this period of forced online teaching, universities have mostly returned to campus teaching with a continued strategy for digitization within higher educat
Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized (3)He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in regions of interest (ROIs) that were d
Introduction: Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic disease with symptoms that limit activities and affect quality of life. RA is associated with an increased risk of developing comorbidities, some of which are also known to be associated with lifestyle habits such as physical activity, diet, smoking, and alcohol. There has been an augmented focus on the implementation
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide association study (GWAS) identified six alleles associated with risk of ovarian cancer for women in the general population. We evaluated four of these loci as potential modifiers of ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Four single-nucleotide polymorphisms (SNP
Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA sequencing to examine ventral midbrain development in human and mouse. We found 25 molecularly defined human cell types, including five subtypes
Progressive supranuclear palsy and Parkinson's disease have distinct underlying neuropathology, but both diseases affect cognitive function in addition to causing a movement disorder. They impair response inhibition and may lead to impulsivity, which can occur even in the presence of profound akinesia and rigidity. The current study examined the mechanisms of cognitive impairments underlying disin
Following systemic injection, hematoporphyrin derivative (HPD) is known to be selectively retained in malignant tissue. This property can be used in a two-fold way: a) for localizing tumours by observing the characteristic dual-peaked laser-induced fluorescence from HPD, and b) for photodynamic therapy (HPD-PDT) using a localized HPD-assisted singlet oxygen release induced by irradiation of 630 nm
BACKGROUND: It is not known if modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer-specific) over 10 years. Cox regression was used to estimate associations between risk factors and
Aim: To compare effects of early insulin vs. glibenclamide treatment on beta-cell function, metabolic control and quality of life (QL) in recently diagnosed patients with type 2 diabetes. Methods: Forty-nine patients with type 2 diabetes diagnosed 0-2 years before inclusion were randomized to two daily injections of premixed 30% soluble and 70% NPH insulin or glibenclamide at six diabetic clinics
No rock at the Earth's surface escapes weathering. This process is the primary source of all the essential elements for organisms, except nitrogen and carbon. Since the onset of terrestrial life, weathering has been accelerated under the influence of biota. The study of biological weathering started at the end of the 19th century. Although the role of bacteria (Eubacteria, Archaea) has attracted a
Background and Objectives: Hand eczema is a chronic disease with negative impact on quality of life (QoL). In this study, QoL in hand eczema patients is assessed and related to age, sex, severity, and diagnostic subgroups. Methods: A total of 416 patients with hand eczema from 10 European patch test clinics participated in the study. Data on QoL were obtained from a self-administered questionnaire
PURPOSE: Epinephrine is used in local anesthetics to induce vasoconstriction and thus reduce bleeding and prolong the anesthetic effect. Finding the optimal delay between the administration of the anesthetic and skin incision to ensure vasoconstriction and minimize bleeding is important and has recently become the subject of debate. This is the first study to assess blood perfusion and oxygen satu
Surface guidance systems enable patient positioning and motion monitoring without using ionising radiation. Surface Guided Radiation Therapy (SGRT) has therefore been widely adopted in radiation therapy in recent years, but guidelines on workflows and specific quality assurance (QA) are lacking. This ESTRO-ACROP guideline aims to give recommendations concerning SGRT roles and responsibilities and
