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Background: Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflicting. Therefore this multicohort study assessed the age of onset in relation to the presence of autoantibodies. The association with characteristics of the anti-citrullinated protein
BACKGROUND—: Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake apoptotic cells (efferocytosis), promotes lesion growth and establishment of a necrotic core. The transcription factor Interferon Regulatory Factor (IRF)-5 is an important modulator of myeloid function and programming. We sought to investig
BACKGROUND: Although rare in the general population, highly penetrant germline mutations in CDKN2A are responsible for 5-40% of melanoma cases reported in melanoma-prone families. We sought to determine whether MELPREDICT was generalizable to a global series of melanoma families and whether performance improvements can be achieved.METHODS: 2,116 familial melanoma cases were ascertained by the inte
BACKGROUND: Risk factors for childhood diarrhea in industrialized countries are not well characterized, although diarrhea remains an important cause of morbidity.METHODS: We conducted a case-control study of 422 cases and 866 controls over 22 months in Denmark. We selected cases among children under 5 years of age with diarrhea. Age-matched healthy controls were selected from the background popula
Women treated with estrogen exhibit a higher risk of developing endometrial cancer. steroid hormones exert their effects on target tissue through specific cytosol receptor protein. Knowledge of this steroid receptor concentration in endometrial carcinoma might facilitate the treatment of recurrences. We have compared the concentrations of endometrial estrogen and progesterone cytosol receptors wit
Liquid biopsy allows assessment of multiple analytes, providing temporal information with potential for improving understanding of cancer evolution and clinical management of patients. Although liquid biopsies are intensely investigated for prediction and response monitoring, preanalytic variables are of primary concern for clinical implementation, including categories of collection method and sam
The ventral mesencephalon, containing the developing dopaminergic neurons of the substantia nigra-ventral tegmental region, was obtained from aborted human fetuses of 9-19 weeks of gestation. The tissue was grafted into the striatum of rats previously subjected to a 6-hydroxydopamine lesion of the mesostriatal dopamine pathway. The graft recipients were immunosuppressed by daily injections of Cycl
THE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception, square root singular near the crack-tip. For overstress exponents less, or equal to 2, a reasonably large regioTHE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception. square root singular near the crack-tip. For overstress exponents less. or equal to 2, a reasonably large re
The incidence of Candida dubliniensis in immunocomprimised patients in Turkey has not yet been determined. In this study the presence of C. dubliniensis in oral rinse samples of human immunodeficiency virus (HIV)-positive patients and healthy controls were investigated. Phenotypic tests like inability of growth at 45 degrees C, colony formation on Staib agar, intracellular beta-D-glucosidase activ
CONTEXT: Fear of pain resonates with most people, in particular, in relation to dying. Despite this, there are still people dying with unrelieved pain.OBJECTIVES: We quantified the risk, and investigated risk factors, for dying with unrelieved pain in a nationwide observational cohort study.METHODS: Using data from Swedish Register of Palliative Care, we analyzed 161,762 expected deaths during 201
Skiljedomsrätt är sedan urminnes tider en använd tvistelösningsmetod. Hänvisningar till skiljerätt finns att hitta i både romersk och gammalgrekisk rätt, så som Digesta, Codex Iustinianus och Novellae. Även Sverige har en lång tradition av kommersiellt skiljeförfarande och metoden har nyttjats som ända sedan Hansan etablerades. Förmodligen har skiljeförfarandet även använts för att avgöra kommersiArbitration is an immemorial dispute settlement method with references to be found in both Roman and ancient Greek law, such as Digesta, Codex Iustinianus and Novellae. Sweden also has a long tradition of commercial arbitration and it has been used as a dispute settlement method at least since the Hanseatic League was established. It is also believed that arbitration was used to settle commercial
I vissa fall uppfattas betalda samarbeten med influencers som genuina rekommendationer och som ett effektivt sätt att påverka konsumentens köpintention. Dock understryks oro för hur betalda samarbeten vilseleder konsumenten genom sublima budskap som sprids genom influencers. Inte bara forskare ifrågasätter trovärdigheten i det som kommuniceras genom betalda samarbeten på sociala medier, utan även
Syftet med denna studie är att undersöka hur Israel-Palestinakonflikten framställs i svensk nyhetsrapportering samt hur ideologiska perspektiv kan påverka mediernas språkbruk och framställning av konflikten. Studien utgår från svenska dagstidningar, Aftonbladet och Svenska dagbladet, vilka ofta uppfattas representera olika politiska orienteringar. Frågeställningen fokuserar på hur konflikterna ges
Människors köpmönster ändras i takt med att digitala lösningar blir en allt mer integrerad del i deras vardag. Det blir allt lättare att hitta produktinformation och inköp kan utföras var som helst. Denna förändring är lätt att se inom de flesta delar av detaljhandeln, men inom livsmedelsbranschen är förändringen inte lika tydlig. Syftet med detta examensarbete var att genomföra en analys av köpmAs digital solutions become a more integrated part of peoples’ everyday life, their purchasing patterns are changing. Today it is easier to research products and purchases can be performed anytime, anywhere. The change is apparent in most retail sectors but not as much in the fast moving consumer goods sector. By using a user-centred approach this master thesis aim to analyse the user behaviour wi
Syftet av detta arbete är att visa hur en person utan insiderinformation kan kartlägga nybyggnationen av kontorsfastigheter och utvärdera huruvida det är en balans mellan utbud och efterfrågan på denna marknad. Arbetet grundar sig i antagandet att det finns en obalans i utbud och efterfrågan på Malmös framtida kontorsmarknad. Till arbetet samlades information från hemsidor, marknadsundersökningar
Straffrätten är ett omfattande rättsområde som ständigt är under utveckling. Det är därför av stor relevans att undersöka och analysera från tid till tid, huruvida rådande principer och presumtioner som tillämpas fortfarande är aktuella i den rådande lagstiftningen, i samband med tillägg och lagändringar. Ett brott som är aktuellt och ett tema för diskussion för myndigheter och regeringen är hedCriminal law is a vast legal area that is constantly under development. For that reason it is important to examine and analyse, from time to time, if the ruling principles and presumptions are up to date with the changes and additions of the law. A crime that is being heavily discussed and is current to our time is honor related crime. Since the year 2020, honor motives are seen as aggravating c
An increased need for elderly care and health care is expected due to a population that is only getting older. Swedish health care is already known to be burdened. As a result, Sweden aims to become the best country in the world in using digitalisation and e-health solutions. This thesis was done in collaboration with Doro Care, an international company that offers digital solutions enabling dig
I dagsläget utförs fullskaliga kapacitetsprov på sprinkleranläggningar med syfte att undersöka om erforderligt tryck och flöde kan erhållas i händelse av brand. Fullskaliga kapacitetsprov är däremot relaterade till risker som lågt tryck i vattenledningsnät, blödning på gjutjärnsrör, översvämning av lågt belägna områden och tryckslag i rör. I detta arbete undersöks om reducerade kapacitetsprov sammTo this date, full-scale capacity tests are performed in sprinkler facilities in order to investigate if sufficient pressure and flow can be achieved in case of fire. Full-scale capacity tests may, however, cause problems such as low pressure in pipes, scaling of pipe walls, flooding of low topography areas, and water hammer. This report intends to research whether reduced capacity tests together
Denna fallstudie belyser hur ett ökat antal av godstransporter påverkar städers förmåga att skapa en hållbar citylogistik. Citylogistiken innefattar många olika intressenter som har olika mål vilket gör att utvecklandet av en hållbar citylogistik som gynnar alla blir komplext. Detta tillsammans med ökade godstransporter gör att städer står för en utmaning i att kunna tillgodose intressenterna behoThis case study highlights how a increasing amount of freight transport affects the citys ability to create an sustainable city logistics. The city logistics comprises multiple stakeholders with different visions which makes the development of an sustainable city logistics more complex. This along with a increased amount of transportations create a challenge in the ability to make the stakeholders
