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p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. In response to DNA-damaging agents, the wild-type p53-activated fragment 1 (WAF1 also known as p21) is an important downstream effector in the p53-specific growth arrest pathway. In breast can
In the same way that the practice of cardiology has evolved over the years, so too has the way cardiology fellows in training (FITs) are trained. Propelled by recent advances in technology-catalysed by COVID-19-and the requirement to adapt age-old methods of both teaching and healthcare delivery, many aspects, or 'domains', of learning have changed. These include the environments in which FITs wor
INTRODUCTION: Inhibitor development against factor VIII (FVIII) is the most common complication of hemophilia A replacement therapy. One of the variables considered to influence inhibitor development is the ABO blood group. Patients with blood group O have, on average, a 30%-40% lower endogenous von Willebrand factor (VWF) concentration. It has been postulated that VWF levels influence inhibitor d
How animals react to violations of expectations offers a valuable lens into their perception of the world. Kea (Nestor notabilis) and Goffin’s cockatoos (Cacatua goffiniana) are optimal animal models to examine susceptibility to violations of expectations owing to their sophisticated physical exploration and cognition skills. This study involved a bait-and-switch of food items varying in desirabil
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NYTT FRÅN SACO-S SLU Innehåll: • Sommarhälsning • Information • Lönerevision • Digitalt medlemsmöte • Webbinarier • SACO-S SLU styrelse Sommarhälsning Saco-S SLU fick under våren en ny styrelse. Vi hälsar tre nya ledamöter välkomna: Malin Connysson, Dennis Andreasson och Ida Wallin. Vi vill även passa på att tacka Annie Drottberger för de år som hon arbetat i styrelsen och stöttat våra medlemmar,
https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/slu/nyhetsbrev/nyhetsbrev_2025-2.pdf - 2026-09-08
The concept of a circular economy (CE) has gained traction in the EU as a pathway towards sustainability. However, beyond the goal of closing resource loops there is no consensus on the key components of CE. Efforts to triangulate a definition of CE found that it is mainly a model for economic prosperity that aims to reconcile economic growth with sustainability. In 2020, the Swedish government ad
Popular Abstract in Swedish Vårt blod består av flera olika specialiserade typer av celler. Dessa utför allt från transport av syre (röda blodkroppar) och sårläkning (blodplättar) till att utgöra vårt immunsystem (vita blodkroppar). Vårt immunförsvar kommer ständigt i kontakt med virus, bakterier och sjuka celler som måste kännas igen och bekämpas. Därför finns det ett kontinuerligt behov av att bB-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. Among these are the transcription factors E2A, HEB, EBF1 and FOXO1 as well as the IL7 signaling cascade.
[The project Millora 2.0: Results 2018–2022] Based on repeated yearly surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southernmost Sweden, analysed in combination with speciesspecific traits and ecological indicator values (EIVs), changes in the flora and vegetation over the last four years are reported. Many of the changes observed, such as significant increasesBased on repeated yearly surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southernmost Sweden, analysed in combination with speciesspecific traits and ecological indicator values (EIVs), changes in the flora and vegetation over the last four years are reported. Many of the changes observed, such as significant increases in lightdemanding, shortlived, pollinatorind
At temperate latitudes, altricial birds and their nestlings need to handle night temperatures well below thermoneutrality during the breeding season. Thus, energy costs of thermoregulation might constrain nestling growth, and low nocturnal temperatures might require resources that parents could otherwise have invested into nestlings during the day. To manipulate parental work rate, we performed brAt temperate latitudes, altricial birds and their nestlings need to handle night temperatures well below thermoneutrality during the breeding season. Thus, energy costs of thermoregulation might constrain nestling growth, and low nocturnal temperatures might require resources that parents could otherwise have invested into nestlings during the day. To manipulate parental work rate, we performed br
Den främsta orsaken till en ökad växthuseffekt anses idag bero på en högre koncentrationav koldioxid i atmosfären. Sedan den industriella revolutionen harmänniskan påverkat mängden koldioxid i atmosfären genom aktiviteter så somförbränning av fossila bränslen, avskogning, förändringar i markanvändning, samtcementproduktion. För att kunna motverka framtida klimatförändringar krävs enfördjupad kunskThis thesis focuses on the development and application of efficient mathematicaltools for estimating and modelling the exchange of carbon dioxide (CO2) between the Earth and its atmosphere; here referred to as the global CO2 surface flux.There are two main approaches for estimating the CO2 flux: Processed based(bottom-up) modelling and atmospheric inversion (top-down) modelling. Thefirst part of t
Communication interventions are commonly proposed as a way to address people’sfear and negative attitudes to build tolerance in shared landscapes between humansand large carnivores. Therefore, managing authorities sometimes respond to people’sfear of brown bears (Ursus arctos) by organizing an information meeting. This studyincreases the understanding of the information meeting to address fear of Communication interventions are commonly proposed as a way to address people's fear and negative attitudes to build tolerance in shared landscapes between humans and large carnivores. Therefore, managing authorities sometimes respond to people's fear of brown bears (Ursus arctos) by organizing an information meeting. This study increases the understanding of the information meeting to address fear
Glas är ett genomsiktligt material som används i byggnader för att utforma miljöer som är ljusa och upplevs som öppna. Modernt byggnadsglas används i konstruktioner som utsätts för betydande laster jämfört med ett traditionellt fönsterglas. Som exempel kan nämnas trappsteg, balustrader, golv, tak och väggpaneler där glasets geometriska utformning kan vara mer eller mindre komplex. Det finns ett beNovel and increased use of glass in building construction has been made possible, as a result of methods of mass production introduced during the 20th century and advanced computational structural analyses. With modern use of glass structures, a range of demands emerge which need to be addressed in the strength design process. The aim of the thesis work has been to develop experimentally verified
Popular Abstract in English In the past ten years, homogeneous charge compression ignition (HCCI) combustion has been one of the subjects receiving great research interests in the combustion research community and the engine industry. This is because HCCI combustion processes have the potential of not only capable providing high efficiency like diesel engine combustion, but also producing much lowLarge Eddy Simulation (LES) modeling is developed to study homogeneous charge compression ignition (HCCI) combustion under different engine operation and mixture conditions, including real engine configurations and generic test cases. A previously developed HCCI model has been validated by comparing the simulation results with engine experiments. A new spark-assisted HCCI (SACI) combustion model h
Popular Abstract in English Typically, when we speak of ionic solutions we mean a salt (as solute) dissolved in some liquid (the solvent). In this thesis, we predominantly consider ionic solutions for which there is no solvent---room-temperature ionic liquids (RTILs). It follows that these liquids have a large concentration of charged particles, a property that causes them to be effective electrRoom-temperature ionic liquids (RTILs) are compounds composed entirely of ions, which are liquid at temperatures below 100 degrees Celsius. Their high ionic strength and strong coupling make them useful for a number of applications, e.g. as electrolytes in supercapacitors. These properties also make them interesting subjects for theoretical research, as the canonical theories of the electrical dou
Popular Abstract in English A biosensor is an analytical device that combines a transducer with a biological sensing element. This sensor is unique and has played an important role for a broad range of applications including clinical analysis and process monitoring. Between different types of biosensors, the capacitive biosensor has recently gained a lot of interest due to its analytical performanIncreasing demands for highly sensitive, accurate, fast and portable analytical assays have led to the development of new analytical tools. The integration of highly specific biological sensing elements and appropriate transducers has enabled design of even more efficient biosensor devices for the detection of target substances. In a clinical setting, early detection of biomarkers is crucial for
