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https://www.mgeo.lu.se/zoran-peric - 2026-10-01

Objective:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. Methods:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (M

BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 bioma

Apheresis with different procedures and devices are used for a variety of indications that may have different adverse events (AEs). The aim of this study was to clarify the extent and possible reasons of various side effects based on data from a multinational registry. The WAA-apheresis registry data focus on adverse events in a total of 50846 procedures in 7142 patients (42% women). AEs were grad

The European Prospective Investigation into Cancer and. Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153457 men, mostly aged 35-70 years) in 23 centres located in 10 European count

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We p

Achromatopsia is a congenital, autosomal recessively inherited disorder characterized by a lack of color discrimination, low visual acuity (<0.2), photophobia, and nystagmus. Mutations in the genes for CNGA3, CNGB3, and GNAT2 have been associated with this disorder. Here, we analyzed the spectrum and prevalence of CNGB3 gene mutations in a cohort of 341 independent patients with achromatopsia. In

We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130,544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were

Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European

A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using mathematical models to identify early somatic genetic deletions in tumor tissues followed by targeted linkage analysis. Comparative genomic hybridization was used to study 61 breast tumors from 37 breast c

Objective: To evaluate the consumption of added fats and oils across the European centres and countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design and setting: 24-Hour dietary recalls were collected by means of standardised computer-guided interviews in 27 redefined EPIC centres across 10 European countries. Subjects: From an initial number of

Background: Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. Methods: We performed a matched case-control study on 1311 pairs of women with known deleterious BRCA1

This thesis is based on five papers (A-E), all treating various applications of Rice's formula. The areas of application are oceanographic and environmental problems. The first three papers treat properties of encountering waves, that is, waves that a ship encounters while sailing on the ocean. Paper A addresses the problem of computing the intensity of such waves and, in particular, the intensit

A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example,

Popular Abstract in Swedish Genetisk information lagras i DNA, som är en mycket stabil molekyl. I våra celler finns samma gener i alla celler. Det är därför av yttersta vikt att uttrycket av generna kan regleras olika i olika vävnader. Bakterier, som är encelliga organismer, måste för att kunna överleva noga kontrollera uttrycket av olika gener beroende på växlingar i omgivningen. Jag har studeratGenetic information, which is stored in DNA, is transferred to messenger RNA (mRNA) in a process called transcription. mRNAs are then translated by ribosomes into proteins which, with some important exceptions, catalyze chemical reactions in cells. Since cells must be able to adapt to changes in the environment, mRNAs must be unstable. The present investigation concerns mRNA degradation mainly in

Denna rapport är skriven inom kursen ”VBRN70 - Brandteknisk riskvärdering” vid Lunds Tekniska Högskola. Rapporten omfattar en brand- och utrymningsanalys av Kungliga Dramatiska Teatern i Stockholm med fokus på personsäkerhet. Analysen inleddes med ett platsbesök för att få bättre kännedom om objektet. Utifrån observationer från platsbesöket och tillgänglig statistik identifierades därefter flertaThis report is a part of the course ”VBRN70 - Brandteknisk riskvärdering” given by Lund University of Technology. The report presents a fire and risk evaluation of the Royal Dramatical Theatre in Stockholm with focus on the safety of people in the building. The analysis started with a site visit to gain more knowledge of the object. From observations from the visit and available statistics on fi

Syftet med detta examensarbete är att studera hur punkt 3.2.1 i Svensk kod för bolagsstyrning har implementerats av bolag på Large Cap-listan och huruvida förändringar i styrelse-sammansättningar har skett sedan den trädde i kraft den 1 juli år 2005. Syftet är även att granska respondenternas syn på huruvida en lag om kvotering vore lämplig för svenska börsbolag. Därtill vill författarna ge försla