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Background/Aims: The liver is a major target organ of graft versus host disease (GvHD) with massive infiltration of alloreactive lymphocytes resulting in hepatitis and hepatocyte injury. Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known. Methods: We have devel
To determine which chemokine receptors might be involved in T lymphocyte localization to the intestinal mucosa, we examined receptor expression on human intestinal lamina propria lymphocytes (LPL), intraepithelial lymphocytes (IEL) and CD45RO+beta7hi gut homing peripheral blood lymphocytes (PBL). Virtually all LPL and IEL expressed CXCR3 and CCR5, receptors that have been associated with Th1(Tc1)/
BACKGROUND: The house dust mite (HDM) Dermatophagoides pteronyssinus is an important source of allergens, which can cause allergic conditions. The cysteine protease activity of Der p 1 may enhance the potency of this major mite allergen through cleavage of CD23 and CD25 from the surface of immune cells, IgE independent mast cell activation, increases in epithelial cell permeability and inactivatio
Carvedilol, an antihypertensive drug with activity on adrenoceptors as well as on calcium channel activity, has recently been introduced. In the present study we investigated whether carvedilol interacts with the cytotoxicity induced by irradiation in vitro as well as in vivo. A daily injection of carvedilol in clinically relevant concentrations (3 mg/kg subcutaneously), 4 days before and 3 days a
We present a versatile and compact fiber optic probe for real-time determination of the absorption and the reduced scattering coefficients from spatially resolved continuous wave diffuse reflectance measurements. The probe collects the diffuse reflectance at six distances in the range 0.6 - 7.8 mm at four arbitrary wavelengths, which were 660, 785, 805, and 974 nm in these experiments. The maximum
Ultrafast time-resolved fluorescence spectroscopy has been used to investigate the excited-state dynamics of the basic eumelanin building block 5,6-dihydroxyindole-2-carboxylic acid (DHICA), its acetylated, methylated, and carboxylic ester derivatives, and two oligomers, a dimer and a trimer in the O-acetylated forms. The results show that (1) excited-state decays are faster for the trimer relativ
BACKGROUND: Reports of esophageal anastomotic complications often involve more gastric than colonic reconstructions and are incomplete because of fragmented followup by physicians unfamiliar with the surgical procedure. STUDY DESIGN: Three hundred ninety-three consecutive esophagectomy patients had prevalence and risk factors determined for graft ischemia and anastomotic leak; 363 of these patient
Patients with cold urticaria can after exposure to cold air or infusions react with hypotension and cardiovascular collapse. We here report on a patient having a severe cold urticaria who because of angina required myocardial revascularization: She was successfully operated in normothermic cardiopulmonary bypass with cardioplegia.
Among the more than 2,000 interments from the Phaleron Burial Ground, 79 individuals buried in the Esplanada mass graves are said to have died violently, perhaps bludgeoned to death. The Esplanada remains were observed in the field by Ingvarsson and Bäckström (2019); ten of these 79 were later excavated and studied by Buikstra and colleagues in a laboratory setting. The field and laboratory analysAmong the more than 2,000 interments from the Phaleron Burial Ground, 79 individuals buried in the Esplanada mass graves are said to have died violently, perhaps bludgeoned to death. The Esplanada remains were observed in the field by Ingvarsson and Bäckström (2019); ten of these 79 were later excavated and studied by Buikstra and colleagues in a laboratory setting. The field and laboratory analys
Precipitates of the topologically close-packed (TCP) phases can significantly impact a material’s mechanical and fracture properties. This theoretical study uses ab initio modeling to investigate the σ phase of WOs, focusing on composition-dependent mechanical and fracture-related properties. We find the effect of Os on WOs σ to be stronger than that of Re in WRe σ phase, with the WOs phase exhibiPrecipitates of the topologically close-packed (TCP) phases can significantly impact a material’s mechanical and fracture properties. This theoretical study uses ab initio modeling to investigate the phase of WOs, focusing on composition-dependent mechanical and fracture-related properties. We find the effect of Os on WOs to be stronger than that of Re in WRe phase, with the WOs phase exhibiting p
Inflammation is present in all stages of atherosclerosis, from fatty streaks to rupture of mature plaques. Tumour necrosis factor (TNF)-alpha is expressed in atherosclerotic lesions but its role in atherogenesis has not been defined. To clarify the role of this cytokine, we administered thalidomide, a compound known to inhibit TNF-alpha production, to homozygous apolipoprotein E-deficient (apoE(-/
This paper formulates a bio-economic model to analyze community incentives for wildlife management under benefit-sharing programs like the Communal Areas Management Programme for Indigenous Resources (CAMPFIRE) in Zimbabwe. Three agents influence the wildlife stock: a parks agency determines hunting quotas, outside poachers hunt illegally, and a local community may choose to protect wildlife by di
The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of complex biological processes. To test this concept, two previously published independent data sets on wounded human epidermis were re-analyzed. The prese
The origin of two large peaks in the atmospheric radiocarbon ((14)C) concentration at AD 774/5 and 993/4 is still debated. There is consensus, however, that these features can only be explained by an increase in the atmospheric (14)C production rate due to an extraterrestrial event. Here we provide evidence that these peaks were most likely produced by extreme solar events, based on several new an
Det övergripande syftet med avhandlingen var att belysa och kontextualisera fysioterapeutiska insatser för personer med schizofreniforma psykoser utifrån aktuell forskning om psykomotorisk funktion och självmedvetande. Självmedvetandeforskning, både experimentell och fenomenologisk, kopplar de mest grundläggande självmedvetandenivåerna till vårt kroppsliga ursprung; hur vi via den sensomotoriska f
Examensarbetets titel: Bland Kulturvetare, Småpåvar och Heliga kor: en Kvalitativ Fallstudie om Organisatoriska Värderingars Dynamik och Tvetydighet Seminariedatum: 2017-06-01 Ämne/kurs: FEKH49, Examensarbete i organisation på kandidatnivå, 15 högskolepoäng Författare: Jimmy Björklund, Andreas Jansson och Adrian Schmidt Handledare: Devrim Göktepe-Hultén Nyckelord: Organisatoriska Värderingar, OrgaTitle: Among Cultural Know-it-alls, Micro-popes and Sacred cows: A Qualitative Case Study of the Dynamics and Ambiguity of Organizational Values Seminar date: 2017-06-01 Course: FEKH49, Bachelor Degree Project in Organization Undergraduate level, 15 University Credit Points Authors: Jimmy Björklund, Andreas Jansson and Adrian Schmidt Advisor: Devrim Göktepe-Hultén Keywords: Organizational Values,
Syfte: Denna uppsats avser att undersöka hur köpprocessen ser ut för konsumenter i generationerna Baby Boomers och Silent Generation under pågående Coronapandemi. Arbetet kommer tydligt fokusera på de fem stegen i The five-stage model för att bidra med ytterligare teoretisk kunskap om köpprocessen online, för konsumenter inom de valda generationerna. Metod: Undersökningen har ett hermeneutiskt f
