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INTRODUCTION: Proton (¹H ) magnetic resonance imaging (MRI) can be utilized to quantify pulmonary edema in endotoxin-induced pulmonary inflammation and hyperpolarized (HP) ³He MRI can assess pulmonary ventilation. Neither of the methods has been applied to assess the impact of a drug on endotoxin-induced pulmonary inflammation in vivo. The aim of the current study was to evaluate the capability of
Progressive joint destruction resulting from intra-articular bleeding is the major morbidity affecting patients with haemophilia (PWH), particularly those with inhibitors. Advances in understanding the detrimental processes set in motion by the exposure of joints to bleeding have shaped current management methods. However, to achieve optimal joint health in PWH, in addition to achieving haemostasi
Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of
The complete amino acid sequence of the single polypeptide chain of human complex-forming glycoprotein heterogeneous in charge (protein HC) isolated from a single individual is reported with the supporting data. The primary structure was determined by automatic degradation of the intact chain and of fragments obtained by chemical and enzymatic degradations of the native or reduced and S-carboxymet
Protein HC (human complex-forming glycoprotein, heterogeneous in charge) is a member of the lipocalin superfamily of hydrophobic ligand-binding proteins. The quantitatively dominating blood plasma form of protein HC is a protein HC-IgA complex (HC-IgA), which is the fourth most abundant immunoglobulin species in plasma. A photodiode array detection system on-line with a high performance liquid chr
Research on younger patients with hip fractures is limited. This study adds knowledge on patient and injury characteristics, and DXA was investigated at the time of the fracture. Risk factors for osteoporosis and fractures were numerous among young patients, and osteoporosis was markedly more prevalent than in the general population.INTRODUCTION: Knowledge on younger patients with hip fractures is
This paper presents a method for three-dimensional (3D) segmentation of blood vessels, using a combination of velocity data and magnitude images obtained using phase contrast MRI. In addition to standard MRI images, phase contrast MRI gives velocity information for blood and tissue. The proposed method uses a variational formulation of the segmentation problem which combines different cues; veloci
A case is presented of extragenital abdominal choriocarcinoma without uterine lesion in a postmenopausal woman. Nineteen years after her antecedent pregnancy, a legal abortion, and thirteen years after her menopause, the patient was admitted to the hospital because of intermittent abdominal pain. Explorative laparotomy revealed a large tumour mass in the greater omentum, mesosigmoideum, peritoneal
The development of the intraovarian adrenergic nervous system was investigated in the guinea-pig by use of chemical determination of catecholamines with high performance liquid chromatography (HPLC) and with the formaldehyde-induced fluorescence method for visualization of adrenergic nerves (Falck-Hillarp technique). Ovaries from fetuses (39-40, 45-50, 55-57, 60-63 days of gestation) and young ani
Wine is an important beverage with a long tradition, and its moderate consumption may be considered beneficial for human health. Although there are many studies regarding phenolic compounds in wines, there is a lack of information about antioxidants and phenolic content in South American wines. In this study, 35 South American red wines from four different countries, vintages 2004–2013, purchased
This project aimed to assess the consistency of hypnotizability over repeated assessments when measured by the Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C), and the Elkins Hypnotizability Scale (EHS) and to contrast score distribution and pleasantness of these scales. University students were administered either the SHSS:C or the EHS twice with a one-week delay by separate experimenters
OBJECTIVES: To examine patient willingness and possible shift in willingness for surgery and to investigate factors associated with this shift, following participation in the digital non-surgical osteoarthritis (OA) treatment program Joint Academy.METHODS: 458 individuals (mean age 62±5.6 years, 67% women) with diagnosed hip or knee were evaluated after six weeks in Joint Academy, comprising educa
Controlled experiments on software variants enable e-commerce companies to increase sales by providing user-adapted functionality. Our goal is to understand how the context of experimentation influences tool support. We performed a case study at Apptus that develops algorithms for e-commerce. We investigated how the case company uses experiments through five semi-structured interviews. We identifi
Background: The survival rate after childhood cancer has improved to 80%. The majority of childhood cancer survivors (CCS) will experience late complications which require follow up care, including access to their individual cancer treatment summary. The need to understand CCS needs and preferences in terms of ways to receive information e.g. digitally, becomes important. This study aims to throug
OBJECTIVE: To evaluate the effect of platelet:erythrocyte (P:E) ratios on Plasmodium falciparum erythrocyte invasion.BACKGROUND: Recent reports have shown that platelets are directly involved in the immune response towards P. falciparum during erythrocyte invasion. However, the literature both supports and conflicts with a role for platelets in limiting invasion. Also, the effect of platelet numbe
The iron-chromium (Fe/Cr) catalyst is used for high-temperature water-gas shift (HT WGS) reaction. A major concern using the Fe/Cr catalyst is that it contains hexavalent chromium (Cr+6) which is a potent carcinogen causing health and environmental issues. In order to reduce the usage of chromium in industrial HT WGS applications, a chromium-free catalyst needs to be developed. The aim of this the
Det har i svensk intern rätt införts regler när avdrag för ränteutgifter inte ska ske när hybrida finansiella instrument orsakar avdrag utan inkludering. Lagstiftningen bygger på OECD:s BEPS åtgärd 2 och EU direktiv. I detta arbete har det undersökts huruvida de svenska reglerna kan tolkas med hjälp av OECD:s BEPS åtgärd 2 när det gäller hybridmomentet och personer som agerar tillsammans. Min bedöIn Swedish internal law, rules have been introduced when deductions for interest expenses should not be made when hybrid financial instruments cause deductions without inclusion. The legislation is based on the OECD's BEPS action 2 and EU directives. In this work, it has been examined whether the Swedish rules can be interpreted with the help of the OECD's BEPS action 2 in terms of the hyb
