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Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 h
The purpose of this work was to compare technetium-99m-diphosphono-propanedicarboxylate (DPD) and iodine-123-metaiodobenzylguanidine (MIBG) scans in the diagnosis and follow-up of neuroblastoma, and to study the role of histological differentiation in the uptake of MIBG. The uptake of MIBG and of DPD were studied retrospectively in 27 patients with neuroblastoma (primary, residual and recurrent tu
Spatial variations in nutrient concentrations and turnover may contribute to variations in productivity within forest ecosystems and be responsible for creating and maintaining diversity of plant species. The aim of this study was to relate spatial patterns in soil nutrient availability and microbial properties in the forest floor and mineral soil in order to explore the controls on variations in
Due to the scarcity of reliable antibodies, RBC typing for Doa and Dob is notoriously difficult. Inaccurate typing can place patients at risk for hemolytic transfusion reactions. The molecular basis of the DOA/DOB polymorphism is associated with three nucleotide changes:378 C>T, 624 T>C,and 793 A>G of DO. While the 378 C>T and 624 T>C are silent mutations, the 793A>G polymorphism in codon 265 enco
Treatment with adrenocorticotrophic hormone (ACTH) has a well-documented cholesterol-lowering effect. Increased uptake of low-density lipoprotein (LDL) by HepG2 cells in response to incubation with ACTH has been demonstrated but the precise cholesterol-lowering mechanism has resisted elucidation. Since apolipoproteins are important determinants of lipoprotein metabolism, we sought to extend the kn
An autoregressive process with Markov regime is an autoregressive process for which the regression function at each time point is given by a nonobservable Markov chain. In this paper we consider the asymptotic properties of the maximum likelihood estimator in a possibly nonstationary process of this kind for which the hidden state space is compact but not necessarily finite. Consistency and asympt
Radiative lifetimes of 15 Tl I levels belonging to the 6s(2)ns(2)S(1/2) (n = 7-14) and 6s(2)nd(2)D(3/2) Rydberg series (n = 6-12) have been measured using a time-resolved laser-induced fluorescence technique. All the measured levels have been excited from the ground state 6s(2)6p(2)P(1/2)(0) (odd parity) with a single-step excitation process. The general perturbation of the ns series by the 6s6p(2
Stimulation of endogenous kinin receptors promotes growth of androgen-independent prostate cancer PC3 cells via activation of the mitogenic extracellular-signal-regulated kinase (ERK) pathway. In the present study, we show that kinin-mediated mitogenic signalling and prostate-cell growth involves two subtypes of bradykinin (BK) receptors, B1R and B2R. Specific stimulation of either B1R or B2R by t
We construct hadronic potentials that describe the spectrum and decays of electromagnetic bound states of hadrons, and are consistent with Chiral Perturbation Theory. This procedure enables one to clarify the status of the calculations-based on potential models-of the electromagnetic corrections to the observables of hadronic atoms and to the strong scattering amplitudes at low energy.
Alteration of the transforming growth factor beta (TGFB) signalling pathway is important in pancreatic carcinogenesis, as shown by the frequent inactivation of the downstream target SMAD4. We recently analysed a series of pancreatic carcinoma cell lines with respect to alterations of five SMAD genes involved in TGFB signalling, and showed that SMAD4 was structurally rearranged in 42% of these. Thi
In 1990, a joint Nordic-Russian project was initiated in order to make independent estimations of the effective dose to selected groups of inhabitants in a highly contaminated area around the city of Novozybkov In the western Bryansk region of Russia. The inhabitants were living in six villages with initial contamination levels of Cs-137 between 0.9 and 2.7 MBq m(-2). Some villages had been decont
Popular Abstract in Swedish I Sverige har intranät inom loppet av ett par år införts i drygt hälften av alla organisationer – privata och offentliga. Intranät har av många setts som ett verktyg för att effektivisera kommunikationen och lärandet. Behovet av effektiv kommunikation och lärande har accelererat under 1990-talet med en allt större konkurrens mellan organisationerna. En god tillgång tillDuring the 1990s, communication and learning attracted heightened attention in organizational contexts. Generally speaking, there is great faith in the significance of ICT for people’s learning. One form of technology which has had a great impact on Swedish organizations is the intranet. Within the course of a few years, intranets have been implemented in just over half of all Swedish organization
Aim: To investigate whether there is any pharmacokinetic rationale for the common practice of administering vincristine to adolescents at relatively lower doses than those to younger children. Methods: A total of 98 children, aged 1.3-17.3 y, with acute lymphoblastic leukaemia (ALL) were studied on day I of induction therapy. Plasma samples were drawn before and 10, 30, 360 and 1380 min after inje
Sediment successions in coastal cliffs around Mezen Bay, southeastern White Sea, record an unusually detailed history of former glaciations, interstadial marine and fluvial events from the Weichselian. A regional glaciation model for the Weichselian is based on new data from the Mezen Bay area and previously published data from adjacent areas. Following the Mikulinian (Eemian) interglacial a shelf
Please cite this paper as: Källén B, Finnström O, Lindam A, Nilsson E, Nygren K-G, Otterblad Olausson P. Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies. BJOG 2010; Objective To compare neonatal outcome among twins conceived after in vitro fertilisation (IVF) with that of spontaneously conceived twins. Design Comparison of different-sex (dizygotic) twins born aft
The radiative lifetime of the 1s2p(1)P state of helium is measured in a two-colour ionization experiment with a 5% accuracy. The state is excited by the 13th harmonic of a tunable 80 ps laser and ionized by a synchronous ultraviolet laser, with a variable time delay. This experiment demonstrates that the high harmonics generated in a jet of rare gas exposed to an intense laser field provide a tuna
