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Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian
The antilipolytic effect of insulin on human abdominal subcutaneous adipose tissue and skeletal muscle during local inhibition of cAMP-phosphodiesterases (PDEs) was investigated in vivo, by combining microdialysis with a euglycaemic, hyperinsulinaemic clamp. During hyperinsulinaemia, the glycerol concentration decreased by 40% in fat and by 33% in muscle. Addition of the selective PDE3-inhibitor a
The physico-chemical aspects of three native Andean starches from Arracacha xanthorriza, Canna edulis and Oxalis tuberosa were investigated. Scanning electron microscopy-investigations showed that granules of A. xanthorriza were the smallest with irregular shape and sizes between 7 and 23 pm, whereas granules of O. tuberosa and C. edulis were both ovally shaped with granular sizes between 20 and 5
Background: To examine whether neighbourhood non-employment is associated with daily smoking after adjustment for individual characteristics, such as employment status. Methods: Cross-sectional study of a simple, random sample of 31,164 women and men aged 25-64, representative of the entire population in Sweden. Data were collected from the years 1993-2000. The individual variables included age, s
SummaryThe expansion of the European Union during the last 2 yr has resulted in the need for a revision of existing guidelines to further harmonize education and training in the specialty of anaesthesiology throughout the European Union. Although each individual country is responsible for its own training and certification, these guidelines are intended to reflect minimum criteria for specialist t
The Streptococcus pyogenes cysteine protease SpeB (streptococcal pyrogenic exotoxin B) is important for the invasive potential of the bacteria, but its production is down-regulated following systemic infection. This prompted us to investigate if SpeB potentiated the host immune response after systemic spreading. Addition of Spa to human plasma increased plasma-mediated bacterial killing and prolon
Reversible changes of the height of a polymer brush containing phenylboronic acid were studied. The polymer brush thickness underwent reversible changes of 0.5-1 nm, in response to the changes in composition of the contacting aqueous phase from deionized water to bicarbonate buffer and vice versa, apparently due to the conformational transition of the weak polyelectrolyte to the more extended elec
Surface emissions of CO2 from fossil fuel combustion (ΦFFCO2) are estimated for the Netherlands for the period of May 2006-June 2009 using ambient atmospheric observations taken at station Lutjewad in the Netherlands (6°21'E, 53°24'N, 1 m. a.s.l.). Measurements of Δ14C on 2-weekly integrations of CO2 and CO mixing ratios are combined to construct a quasi-continuous proxy record (FFCO2*) from which
Selection can facilitate diversification by inducing character displacement in mate choice traits that reduce the probability of maladaptive mating between lineages. Although reproductive character displacement (RCD) has been demonstrated in two-taxa case studies, the frequency of this process in nature is still debated. Moreover, studies have focused primarily on visual and acoustic traits, despi
Under anställningsintervjuer ägnar individer stor uppmärksamhet åt sitt uppträdande. Intervjusituationen är alltså en extremt tydlig form av "impression management" som innebär att individerna uppträder och uttrycker sig på ett sätt som de tror andra tycker är högt värderat. I detta sammanhang kan man säga att individernas roller uppstår genom andras förväntningar och att det är de okont
The mechanisms of protein folding and aggregation are investigated by computer simulations of all-atom and reduced models with sequence-based potentials. A quasi local Monte Carlo update is developed in order to efficiently sample proteins in the folded phase. A small helical protein, the B-domain of staphylococcal protein A, is studied using a reduced model. In the thermodynamically favoured topo
Popular Abstract in Swedish Inom analytisk kemi är selektivitet en viktig fråga. Att kunna urskilja ett specifikt ämne av låg koncentration i ett komplicerat prov är viktigt inom t.ex. medicin, miljöanalys och livsmedelsindustri. Naturen har under miljontals år utvecklat selektiva system. Ett exempel på ett sådant system är antikropparna i människans immunförsvar; om ett främmande ämne kommer in iThe thesis is a bioelectrochemical study of heme enzymes, mainly peroxidases and cellobiose dehydrogenases (CDH). It covers both fundamental and applied aspects, viz. studies of the direct electron transfer and kinetics of enzymes on electrodes, and the development of amperometric enzyme-based biosensors. The kinetics of the direct and mediated electron transfer of a wide range of peroxidases (bo
Even if practitioners want to adopt new manufacturing technologies, there is a lack of comprehensive tools to support their decisions, regarding both cost and sustainability. This paper reviews and compares the practical use of Life Cycle Costing (LCC) with a performance part costing (PPC) model, chosen based upon the criteria of providing in-depth analysis capabilities and the prospect of integraIn today’s business environment, the trend towards more product variety and customization is unbroken. Due to this development, the need of agile and reconfigurable production systems emerged to cope with various products and product families. To design and optimize production systems as well as to choose the optimal product matches, product analysis methods are needed. Indeed, most of the known m
