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The objective of this work was to describe requirements for inclusion of soluble biomarkers in osteoarthritis (OA) clinical trials and progress toward OA-related biomarker qualification. The Guidelines for Biomarkers Working Group, representing experts in the field of OA biomarker research from both academia and industry, convened to discuss issues related to soluble biomarkers and to make recomme

Using p-aminothiophenol (PATP) molecules on a gold substrate and high-vacuum tip-enhanced Raman spectroscopy (HV-TERS), we show that the vibrational spectra of these molecules are distinctly different from those in typical surface-enhanced Raman spectroscopy. Detailed first-principles calculations help to assign the Raman peaks in the TERS measurements as Raman-active and IR-active vibrational mod

Some pregnancy complications are characterized by increased levels of cell-free fetal (cffDNA) and maternal DNA (cfmDNA), the latter may also be elevated during physical strain. This study aims at assessing the impact of exercise and metformin intervention in pregnancy, and to compare the levels of cell free DNA in pregnant women with or without PCOS diagnosis.

Ex vivo lung perfusion (EVLP) is a novel procedure designed to rapidly assess and recondition unusable donor lungs for transplantation (LTx). EVLP may reduce graft immunogenicity and allorecognition via removal of passenger leukocytes. We aimed to explore this hypothesis using human EVLP and in vitro analysis.

Lifetimes of four short-lived levels belonging to the 4f(8)(F-7)6p configuration of Tb III have been measured using a two-step excitation time-resolved laser-induced fluorescence technique. They agree quite well with multiconfigurational relativistic Hartree-Fock calculations performed with inclusion of core-polarization effects. Using the experimental lifetimes and the theoretical branching fract

Increased morbidity among teenage smokers has been reported, but specific current health problems and medication use other than of alcohol and narcotics have received less attention. The aim of this study was to examine the association between health problems and daily smoking in teenagers. Ninety percent of all teenagers attending junior high or high schools participated in a cross-sectional stud

Background : Reduced taste and smell, chewing problems and swallowing dysfunction are common among elderly people and affect perception, food choice and the ability to eat. Objective : To study the preference for texture-modified carrot and meat products in elderly people aiming to meet the needs of people with impaired chewing and/or swallowing. Design : Data were collected using questionnaires

The impact of the optical properties on the annual performance of flat plate collectors in a Swedish climate has been estimated with the MINSUN program. The collector parameters were determined with a theoretically based calculation program verified from laboratory measurements. The importance of changes in solar absorptance and thermal emittance of the absorber, the addition of a teflon film or a

We investigate the observed depletion of red giants in the cores ofpost-core-collapse globular clusters. In particular, the evolutionaryscenario we consider is a binary consisting of two low-mass stars whichundergoes two common-envelope phases. The first common-envelope phaseoccurs when the primary is a red giant resulting in a helium white dwarfand main-sequence star in a detached binary. The sec

Field-growing silver birch (Betula pendula Roth) clones (clone 4 and 80) were exposed to elevated CO2 and O-3 in open-top chambers for three consecutive growing seasons (1999-2001). At the beginning of the OTC experiment, all trees were 7 years old. We studied the single and interaction effects of CO2 and O-3 on silver birch below-ground carbon pools (i.e. effects on fine roots and mycorrhizas, so

Haemophilia is a congenital disorder with bleeding episodes as its primary symptom. These episodes can result in negative outcomes including joint damage, loss of active days due to hospitalization and reduced quality of life. Effective treatment, however, can improve the outcome. Registries have been used as a valuable source of information regarding the monitoring of treatment and outcome. The t