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Objective: To explore the direct and Indirect costs in a cohort of 225 risperidone-treated patients with schizophrenia followed up annually during 5 years. Method: Data on costs for medication, hospitalization, sheltered living and productivity losses, as well as degree of social isolation, were collected. Results: The direct costs were dominated by hospitalization and sheltered living expenses, w
1 In the present study, the inhibitory effects of the selective beta 2-adrenoceptor agonists, salmeterol, formoterol and salbutamol, have been investigated on contractions of ferret trachea induced both by endogenous and exogenous acetylcholine. The aim of the study was to evaluate quantitative and/or qualitative differences in response which may indicate both pre-and post-junctional sites of acti
We describe a general approach to rapidly obtain the DNA sequence encoding the variable region of any immunoglobulin chain using the polymerase chain reaction and a mixture of upstream primers corresponding to the leader sequence, and one downstream primer designed from the conserved nucleotide sequence of the constant region. The approach was applied to five different hybridomas producing human m
Objective: To study antibodies to cyclic citrullinated peptides (anti-CCP) and rheumatoid factor in patients with active, severe extra-articular rheumatoid arthritis (ExRA) compared with controls without ExRA. Methods: 35 consecutive patients with severe ExRA manifestations according to predefined criteria were studied. 70 patients with rheumatoid arthritis, but no ExRA manifestations, individuall
In addition to the two known compounds neotautenol [2] and erythrinassinate B [4], two new compounds, an isoflavanone named sigmoidin J [1] and a coumestan derivative named sigmoidin K [3], have been isolated and characterized from the root bark of the Cameroonian medicinal plant Erythrina sigmoidea. Their structures have been established as 7, 4'-dihydroxy-2',5'-dimethoxy-6'(gamma, gamma-dimethyl
To investigate the epidemiology of infection with delta (delta) agent in a Swedish city, 181 chronic carriers of hepatitis B surface antigen (HBsAg) and 599 patients with acute, self-limited hepatitis B were analyzed for delta antigen and antibody to delta antigen (anti-delta). The study covered the period from 1970 to 1981. The delta agent was found to have been introduced to this population in 1
Src homology 2 (SH2) domains recognize phosphotyrosine (pY)-containing sequences and thereby mediate their association to ligands. Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase, in which mutations cause a hereditary immunodeficiency disease, X-linked agammaglobulinemia (XLA). Mutations have been found in all Btk domains, including SH2, We have analyzed the structural and
A set of fossil bones from Romania has been analysed by accelerator mass spectrometry and by neutron activation analysis in order to estimate their age. The temporal attributing of Malu Rosu archaeological settlement has been extensively analyzed. The radiocarbon age, determined by accelerator mass spectrometry, for this site is 5510+/-200 BP. This is in agreement with the age of 6000+/-2000 BP, o
Low-temperature absorption and fluorescence spectra of fully active cores and membrane-bound PS II preparations are compared. Detailed temperature dependence of fluorescence spectra between 5 and 70 K are presented as well as 1.7-K fluorescence line-narrowed (FLN) spectra of cores, confirming that PS II emission is composite. Spectra are compared to those reported for LHCII, CP43, CP47 and D1/D2/c
Olanzapine (Zyprexa(R)) was approved for general prescription in Sweden in November 1996, and an HPLC-based therapeutic drug monitoring (TDM) routine for serum olanzapine (OLA) and its major metabolite. N-demethylolanzapine (DMO) was established in February 1997. During 1997 to 1999, a total of 753 TDM requests for a total of 545 Swedish patients was analyi.ed. Additional patient information oil c
The aim of this study was to evaluate the relationship between respiratory symptoms, lung function and inflammatory markers in 'healthy' smokers. The study population was recruited from an epidemiological study with subjects of the same age, 60 years. Only smokers who considered themselves healthy (n=58) and a random sample of never-smokers (n=34) were investigated. All subjects underwent lung fun
Tropical forests provide essential ecosystem services, playing a critical role in climate regulation, biodiversity conservation, and regional hydrological cycles while also supporting livelihoods. However, they are increasingly threatened by deforestation and land-use change. Accurate land cover (LC) mapping is vital to monitor these changes, but mapping tropical forests is challenging due to comp
OBJECTIVE: To explore trajectories of 12-week adherence to a digital education and exercise therapy for knee and hip osteoarthritis (OA), associations with baseline characteristics, and trajectories of patient-reported outcomes measures (PROMs) up to 1-year follow-up.DESIGN: Retrospective cohort (registry) study.METHODS: Weekly data on adherence (i.e. the percentage of completed activities (exerc
The European spruce bark beetle is a major disturbance agent in Norway spruce forests in Europe, and with a changing climate it is predicted that damage will increase. To prevent the bark beetle population buildup, and to limit further spread during outbreaks, it is crucial to detect attacked trees early. In this study, we utilize Sentinel-2 data in combination with a risk map, created from geodat
Coating Ti-based implants with bioactive materials promotes joining between the prostheses and the bone as well as increasing long-term implant stability. In the present work, the interface between Ti-6Al-4V and bioactive silicate glass coatings, prepared using a simple enameling technique, is analyzed. High-resolution transmission electron microscopy of the glass/alloy interface shows the formati
We present a unique comparative analysis, and evaluation of vision, radio, and audio based localization algorithms. We create the first baseline for the aforementioned sensors using the recently published Lund University Vision, Radio, and Audio (LuViRA) dataset, where all the sensors are synchronized and measured in the same environment. Some of the challenges of using each specific sensor for in
China is a global leader in the manufacturing of clean energy. Unexpectedly, the severe environmental degradation occurring since the 1990s and the critical air pollution situation are now under control. Many steps still need to be taken in order to fix all the problems linked with the long-term environmental crisis. However, since Xi Jinping’s advent to power in 2012, Beijing has undertaken a sol
