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The purpose of the present study was to investigate the amplifying function of the nucleus accumbens septi region (NAS) in 6-hydroxydopamine (6-OHDA)-induced rotational behaviour by implanting fetal dopamine (DA)-rich mesencephalic cell suspensions unilaterally in the NAS of rats previously subjected to combined mesostriatal (MS) and NAS 6-OHDA lesions. First, all the rats received a unilateral 6-
Eleven human primary rhabdomyosarcomas (RMSs), including all histological variants, were analyzed morphologically, immunohistochemically for intermediate filament proteins and actin isoforms, and by means of Northern blots with probes specific for total actin, alpha-skeletal (SK), alpha-cardiac (CARD), and alpha-smooth muscle actin messenger (m)RNAs. All tumors disclosed ultrastructural evidence o
Samples were prepared for ultrastructural studies of the intact interface between metallic implants and tissue by transmission electron microscopy. The method is based on plastic embedding of implant and tissue and subsequent removal of the bulk metal by electrochemical dissolution (electropolishing), to facilitate preparation of ultrathin sections for transmission electron microscopy. Surface sen
Miljö- och klimatpåverkan är idag centralt inom byggbranschen. För att uppnå de globala och nationella mål som existerar krävs fler åtgärder för att minska byggsektorns klimatpåverkan. Byggsektorn står idag för cirka 21 % av Sveriges totala utsläpp av växthusgaser. Klimatberäkningar är ett sätt att uppmärksamma aktörer på den klimatpåverkan branschen utgör och öka motivationen till förändring. I d
CCAAT-enhancer binding protein β (C/EBPβ) is a transcription factor that has a critical role in mammary gland development and breast cancer progression. Loss of C/EBPβ increases metastatic dissemination of mouse mammary tumor cells. However, the mechanism by which C/EBPβ expression affects metastasis formation remains unknown. This study aims at determining the relationship between C/EBPβ and surv
Superantigens are toxins produced by Staphylococcus aureus, called staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T cell receptor (TCR) and major histocompatibility complex class II, triggering a massive T cell activation and hence disease. Due to high stability and toxicity, superantigens are potential agents of bioterrorism. Hence, antagonists may not only be usefu
Diiron complexes bearing redox active diamine ligands have been studied as models of the active site of [FeFe]-hydrogenases. Heating [Fe2(CO)6(μ-edt)] (edt = 1,2-ethanedithiolate) with 2,2′-bipyridine (2,2′-bipy) or 1,10-phenanthroline (1,10-phen) in MeCN in the presence of Me3NO leads to the formation of [Fe2(CO)4(κ2-2,2′-bipy)(μ-edt)] (1-edt) and [Fe2(CO)4(κ2-1,10-phen)(μ-edt)] (2-edt), respecti
Patients and methods A comprehensive literature search was conducted. We measured pooled rate of lesion visualization improvement and improvement in lesion detection comparing FICE settings 1 – 3 and WLE, for angioectasias and ulcers/erosions. Pooled results were derived using the random-effects model because of high heterogeneity as measured by I 2. Repeated-measures analysis of variance (ANOVA)
DN DEBATT 15/3. Sedan industrialiseringens början har vi använt omkring fyra femtedelar av den mängd fossilt kol som får förbrännas för att vi ska klara Parisavtalet. Vi har bara en femtedel kvar och det är bråttom att kraftigt reducera utsläppen. Det har Greta Thunberg och de strejkande ungdomarna förstått. Därför stödjer vi deras krav, skriver 270 klimatforskare.
This chapter situates John Rawls’ just savings principle in a discussion about how much a nation-state should save. The main question addressed is whether this principle is a viable alternative to the dominant utilitarian theory of optimal growth. Rawls certainly gives savings a different aim (i.e., to create and maintain just institutions) and introduces additional permissibility conditions on re
Universitet har vanligen utvecklat etiska riktlinjer för undervisning, men dessa fokuserar ofta på att avskräcka från oärlighet genom upptäckt och bestraffning i stället för att uppmuntra till ett fruktbart beteende. Universitet, fakulteter, institutioner och lärare har ett stort ansvar för att sprida kunskap om akademisk hederlighet till sina studenter. En internetbaserad enkätundersökning genom
Developments in ambulatory electrocardiogram (ECG) technology have led to vast amounts of ECG data that currently need to be interpreted by human technicians. Here we tested an artificial intelligence (AI) algorithm for direct-to-physician reporting of ambulatory ECGs. Beat-by-beat annotation of 14,606 individual ambulatory ECG recordings (mean duration = 14 ± 10 days) was performed by certified E
The addition of a do-not-operate (DNO) section to current medical orders for life-sustaining treatment (MOLST) and physician orders for life-sustaining treatment (POLST) medical order forms would more completely document patients' wishes for invasive interventions at the end of life. We propose a modification of the MOLST and POLST forms, in addition to hospital and electronic medical records, to
