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Basal cell carcinoma (BCC) is the most common form of skin cancer with the current diagnostic procedures relying on surgical excisions and histopathological analyses. Incomplete removal of the tumor necessitates additional surgery, which is both costly and time-consuming. To address this, non-invasive diagnostic techniques capable of determining the dimensions of skin cancer preoperatively are urg
Tool Coating is a method for enhancing cutting efficiency and extending tool life, essential for machining hard materials. While Polycrystalline Cubic Boron Nitride (PcBN) tools are already well-suited for harsh machining conditions, their durability can be further improved with coatings. However, as the machining operation continues, tool coating loss occurs, reducing the durability of the tool a
In hard milling operations under severe conditions, polycrystalline cubic boron nitride (PcBN) tools are commonly used. Monitoring their degradation in real time is important to maintain process stability and to reduce tool costs. To use accelerometer data sampled with relatively low sampling frequency enables efficient data collection and analysis. However, the high noise levels in machining requ
Many vibration signals produced by rotating machines have been shown to be second-order cyclostationary. This means that the spectral correlation function can be used to identify cyclic frequencies associated with e.g. faulty machine parts. However, due to spectral leakage, the spectral correlation function often has poor localization of signal components, leading to sub-par fault detection. Recen
The acylative modification of IDN 5390 (3a), a 7,8-secotaxoid under preclinical development, was investigated. A modest decrease of potency was observed upon acylation of the primary and the enolic hydroxyls, suggesting that, just like in paclitaxel, the hydroxyl groups in the upper right-hand sector are not critical for cytotoxicity. The activity of these analogues, and especially of the chemical
OBJECTIVE: To present our results of non-surgical primary management of appendiceal abscesses using ultrasonic percutaneous drainage under local anaesthesia, and selective interval appendicectomy. DESIGN: Retrospective study. SETTING: University hospital, Sweden. SUBJECTS: 24 patients with appendiceal abscesses 3-12 cm in size. INTERVENTIONS: Primary ultrasonic percutaneous drainage under local an
Objective: To investigate prolactin levels and related side effects in 128 men and 90 women initially treated with risperidone. Method: Patients initially treated with risperidone were followed over 5 years, during which 45% were switched to other antipsychotic drugs. Results: Initially, prolactin levels were fivefold the norm in women, and threefold in men. Diagnosis did not affect the prolactin
Inhaled corticosteroid (ICS) therapy such as fluticasone propionate (FP) is effective in moderate-to-severe asthma, but for patients on ICS who still experience symptoms, treatment guidelines recommend either increasing the dose of ICS or adding a long-acting beta2-agonist such as salmeterol or formoterol. Several studies have now shown that adding salmeterol provides greater clinical benefit than
In neutron grating interferometry, the dark-field image visualizes the scattering properties of samples in the small-angle and ultra-small-angle scattering range. These angles correspond to correlation lengths from several hundred nanometers up to several tens of micrometers. In this article, we present an experimental study that demonstrates the potential of quantitative neutron dark-field imagin
Randomised control trials (RCTs) do not always reflect real-life outcomes for glucose-lowering drugs. In this work we compared RCT and real-life data on the efficacy of the dipeptidyl peptidase-IV (DPP-4) inhibitor vildagliptin or sulfonylureas when added to metformin.
Vascular endothelial cells that are in direct contact with blood flow are exposed to fluid shear stress and regulate vascular homeostasis. Studies report endothelial cells to release ATP in response to shear stress that in turn modulates cellular functions via P2 receptors with P2X4 mediating shear stress-induced calcium signaling and vasodilation. A recent study shows that a loss-of-function poly
The issue of natural and forced groundwater movements, and its effect on the performance of ground heat exchangers is of great importance for the design and sizing of borehole thermal energy systems (BTESs). In Scandinavia groundwater filled boreholes in hard rock are commonly used. In such boreholes one or more intersecting fractures provide a path for groundwater flow between the borehole and th
Mikhlin's method for solving Laplace's equation in domains exterior to a number of closed contours is discussed with particular emphasis on the Dirichlet-Neutnann map. In the literature there already exit tyro computational modes for Mikhlin's method. Here a new mode is presented. The new mode is at least as stable as the previous modes. Furthermore, its computational complexity in the number of c
Palaeoecological analyses from a small fen deposit, combined with pollen analysis from buried soil profiles under prehistoric burial mounds, have been used to investigate the timing and vegetation change associated with the Holocene development of a cultural landscape in southern Sweden. Traditional pollen analysis is complemented with plant macrofossil analysis and soil pollen analysis from withi
Problem: Kan den externa värderingen, i form av aktiekursen, förklaras av en enskild aktivitet eller av flera aktiviteter i läkemedelsföretagens produktlivscykler? Syfte: Syftet med denna uppsats är att pröva om förändringar i läkemedelsföretagens börskursutvecklingar kan förklaras av aktiviteter i företagens produktlivscykler. Metod: För att på bästa sätt uppfylla vårt syfte är uppsatsen indelad
Sammanfattning: Arbetets syfte var att göra en utvecklingshistorisk tolkning av området kring Örseryd, mellersta Blekinge. Ett 2000 x 600 m stort område ytkarterades, varefter olika enheter definierades och korrelerades med tidigare undersökningar utförda i Blekinge. Arbetet koncentrerades sedan till torvmarksområden påträffade under ytkarteringen. Tre torvmarksområden kan urskiljas inom undersöknSummary: The aim of this investigation was to study the Holocene history of a river valley near the village of Örseryd, situated in the middle part of the county of Blekinge in South Sweden. Covering 2000 x 600 m the area was investigated by survey mapping. Grain size analysis were made on representative samples and the different sediments were correlated to lithostratigraphic units defined in ear
Summary: The investigated area - the parish of Baldringe lies c. 10 km north of Ystad in the province of Skåne, southern Sweden. The area is a part of the inner hummocky landscape. Samples for pollen analysis were taken in an alder fen, surrounded by pastures. The locality is named Skogshejdan, and is situated within the former outlying land to the village Baldringe. The main purpose of the study
Since the early 1980’s and up until today many organizations have realized the importance of paying more and more attention to the effective strategic planning of the information systems resources. There are several reasons for this that where recognized by Pyburn (1983), one was the high speed of technological progress both in regards to IT and Telecoms facilities. Another key factor, which is ve
Absorption and fluorescence spectral properties of J-aggregates of core-tetrasubstituted perylene bisimide (PBI) dyes have been investigated in the temperature range from 300 to 5 K. A special feature of the present PBI J-aggregates is that, in contrast to classical J-aggregates like that of pseudoisocyanine (PIC), the chromophores are held together not only by van-der-Waals interactions but also
