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We examined the transduction efficiency of different adeno-associated virus (AAV) capsid serotypes encoding for green fluorescent protein (GFP) flanked by AAV2 inverted terminal repeats in the nonhuman primate basal ganglia as a prelude to translational studies, as well as clinical trials in patients with Parkinson's disease (PD). Six intact young adult cynomolgus monkeys received a single 10 mu l
In this paper, a novel method for analysing a bird’s song is presented. The song of male great reed warblers is used for developing and testing the methods. A robust method for detecting syllables is proposed and a classification of those syllables as compared to reference syllables is done. The extraction of classification features are based on the use of singular vectors in different time-freque
PURPOSE: To investigate a wavelet-based filtering scheme for denoising of arterial spin labeling (ASL) data, potentially enabling reduction of the required number of averages and the acquisition time. METHODS: ASL magnetic resonance imaging (MRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer. The signal difference between a labeled image, where inflowing arte
Several studies have shown the value of using proximity data to understand the social context of users. To simplify the use of social context in application development we have developed Proximates, a social context engine for mobile phones. It scans nearby Bluetooth peers to determine what devices are in proximity. We map Bluetooth MAC ids to user identities on existing social networks which then
When robots are working in dynamic environments, close to humans lacking extensive knowledge of robotics, there is a strong need to simplify the user interaction and make the system execute as autonomously as possible. For industrial robots working side-by-side with humans in manufacturing industry, AI systems are necessary to lower the demand on programming time and expertise. We are convinced th
The discovery of the role of α-synuclein in the pathogenesis of Parkinson's disease (PD) has opened new possibilities for the development of more authentic models of Parkinson's disease. Recombinant adeno-associated virus (AAV) and lentivirus (LV) vectors are efficient tools for expression of genes locally in subsets of neurons in the brain and can be used to express human wild-type or mutated α-s
Machine learning algorithms for myoelectric pattern recognition require substantial user-specific training data, limiting broader applications of electromyography (EMG) in human–computer interfacing. Here, we present a framework for EMG-mediated motor intent decoding designed to function for new users without collecting user-specific training data. We introduce a Transformer-based architecture, te
In 2025 Huminfra, Sweden’s national infrastructure for digital and experimental humanities, entered its second funding period, the consolidation phase, and successfully met all first-year targets.First, the Huminfra website, https://www.huminfra.se/, was further developed and maintained. This is the central gateway to Swedish digital and experimental research resources which collates and links to
Huminfra, Sweden’s national infrastructure for digital and experimental Humanities, consisting of 12 nodes, successfully met all its goals in 2024—the final year of its first funding period.First, the Huminfra website, https://www.huminfra.se/, which collates and links toSwedish digital and experimental research resources (instruments, tools, expertise, materials, training events) was further deve
Huminfra is a distributed national infrastructure led by Lund University, which brings together 12 nodes in the domains of digital and experimental Humanities. In its second year, 2023, Huminfra launched www.huminfra.se, a website which collates and links to Swedish digital and experimental research resources (instruments, tools, expertise, materials, and training events) drawing on an inventory m
Huminfra is a distributed national infrastructure led by Lund University, which brings together 12 nodes in the domains of digital and experimental Humanities. In its first year of existence, Huminfra has established an organisational management structure at multiple levels, drawn up policy documents, routines and workflows, and held consortium meetings as well as smaller more focused node meeting
Proteoglycans with their attached negatively charged glycosaminoglycans (GAGs) play a crucial role in proper tissue morphology and function throughout the body. Their complex meshwork exists either as thin sheet-like basement membranes lining epithelial cells as in airway bronchial and alveolar epithelial tissue or as a meshwork-like interstitial extracellular matrix (ECM) that forms porous three-
Altermagnetism represents a recently established class of collinear magnetism that combines zero net magnetization with momentum-dependent spin polarization, enabled by symmetry constraints rather than spin-orbit coupling. This distinctive behavior gives rise to sizable spin splitting even in materials composed of light, earth-abundant elements, offering promising prospects for next-generation spi
Time-dependent diffusion MRI enables the estimation of water exchange rates in vivo. Most studies attribute these estimates to membrane permeability. However, non-permeative geometric exchange may also contribute. The present study investigates the contribution of geometric exchange between dendritic spines and shafts to diffusion MRI-derived exchange estimates. Monte Carlo simulations were perfor
Abstract published in relation to the Nordic COnference on Forensic Medicine.
Fire is a global phenomenon and a key Earth system process. Extreme fire events have increased in recent years, and fire frequency and intensity are projected to rise across most regions and biomes, posing substantial challenges for ecosystems, the carbon cycle, and society. The Fire Model Intercomparison Project (FireMIP), launched in 2014, has advanced global fire modeling in Dynamic Global Vege
Background – Cognitive impairment is a clinically significant, non-motor symptom of Parkinson’s disease (PD) commonly associated with reduced quality of life, increased caregiver burden, and higher risk of progression to dementia. Mild cognitive impairment in PD (PD-MCI) is expressed heterogeneously, with likely prognostic implications. This pilot study evaluated the feasibility and preliminary di
Apparent diffusion coefficient (ADC)-fMRI offers a promising functional contrast, capable of mapping neuronal activity directly in both grey and white matter. However, previous studies have shown that diffusion-weighted fMRI (dfMRI), from which ADC-fMRI derives, is influenced by blood-oxygen level dependent (BOLD) effects, leading to a concern that the dfMRI contrast is still rooted in neurovascul
The outermost skin layer, the stratum corneum (SC), forms a responsive barrier where molecular transport depends on the structure and dynamics of its extracellular lipid matrix. SC lipids predominantly adopt a long-periodicity lamellar (LPP) phase across a wide hydration range, but how this structural resilience relates to the strong hydration dependence of skin permeability remains unclear. It is
