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The pre-tetramerization loop (PTL) of the human tumor suppressor protein p53 is an intrinsically disordered region (IDR) necessary for the tetramerization process, and its flexibility contributes to the essential conformational changes needed. Although the IDR can be accurately simulated in the traditional manner of molecular dynamics (MD) with the end-to-end distance (EEdist) unhindered, we sough
Current literature show that frequency diverse arrays (FDAs) are able of producing range–angle-dependent and time-variant transmit beampatterns, but the resulting time and range dependencies and their characteristics are still not well understood. This paper examines the FDA transmission model with an emphasis on analyzing the beam auto-scanning characteristics and the equivalence with the MIMO be
In this paper, we considered the real-time modeling of an underwater channel impulse response (CIR), exploiting the inherent structure and sparsity of such channels. Building on the recent development in the modeling of acoustic channels using a Kronecker structure, we approximated the CIR using a structured and sparse model, allowing for a computationally efficient sparse block-updating algorithm
Accurately predicting terrestrial ecosystem responses to climate change over long-timescales is crucial for addressing global challenges. This relies on mechanistic modeling of ecosystem processes through land surface models (LSMs). Despite their importance, LSMs face significant uncertainties due to poorly constrained parameters, especially in carbon cycle predictions. This paper reviews the prog
Background: The development of a reactive tumour stroma is a hallmark of tumour progression and pronounced tumour stroma is generally considered to be associated with clinical aggressiveness. The variability between tumour types regarding stroma fraction, and its prognosis associations, have not been systematically analysed. Methods: Using an objective machine-learning method we quantified the tum
Tog köksvägen Lunds universitets magasin | Nr 5 | 2014 till juristprogrammet Berlin gav ny luft under vingarna Hur fungerar folkmördare? Motig medfinansiering 2 LUM nr 5 | 2014 LUM nr 5 | 2014 3 Under tre intensiva majdagar svepte Futuralkarnevalen in över Lund med 5.500 kreativa karnevalister som satte framtiden i fokus. LUM:s utsända summerar några av årets karnevals- trender. Regnbågstema: Det
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-5-2014.pdf - 2026-11-08
This work is concerned with determining optimal sensor placements that allow for an accurate location estimate of structured signal sources, taking into account the expected location areas and the typical range of the parameters detailing the signals. In the presentation, we illustrate the technique for tonal sound signals, exploiting the expected harmonic structure of such signals. To determine p
This study investigates possible structural changes of an intrinsically disordered protein (IDP) when it adsorbs to a solid surface. Experiments on IDPs primarily result in ensemble averages due to their high dynamics. Therefore, molecular dynamics (MD) simulations are crucial for obtaining more detailed information on the atomistic and molecular levels. An evaluation of seven different force
Kinesthetic teaching allows human operators to reprogram part of a robot’s trajectory by manually guiding the robot. To allow kinesthetic teaching, and also to avoid any harm to both the robot and its environment, Cartesian impedance control is here used for trajectory following. In this paper, we present an online method to modify the compliant behavior of a robot toward its environment, so that
ObjectivesProstate volume (PV) in combination with prostate specific antigen (PSA) yields PSA density which is an increasingly important biomarker. Calculating PV from MRI is a time-consuming, radiologist-dependent task. The aim of this study was to assess whether a deep learning algorithm can replace PI-RADS 2.1 based ellipsoid formula (EF) for calculating PV.MethodsEight different measures of PV
Part of the Northern Hemisphere has experienced widespread autumn cooling during the most recent decades despite overall warming, but how this contrasting temperature change has influenced the ecosystem carbon exchange remains unclear. Here, we show that autumn cooling has occurred over about half of the area north of 25° N since 2004, producing a weak cooling trend over the period 2004–2018. Mult
Land ecosystems contribute to climate change mitigation by taking up approximately 30% of anthropogenically emitted carbon. However, estimates of the amount and distribution of carbon uptake across the world's ecosystems or biomes display great uncertainty. The latter hinders a full understanding of the mechanisms and drivers of land carbon uptake, and predictions of the future fate of the land ca
Understanding uncertainties and sensitivities of projected ecosystem dynamics under environmental change is of immense value for research and climate change policy. Here, we analyze sensitivities (change in model outputs per unit change in inputs) and uncertainties (changes in model outputs scaled to uncertainty in inputs) of vegetation dynamics under climate change, projected by a state-of-the-ar
Increasing tree growth and mortality rates in Europe are still poorly understood and have been attributed to a variety of drivers. This study explored the role of climate drivers, management and age structure in driving changes in tree mortality rates in six Central European countries from 1985 to 2010, using the process-based vegetation model LPJ-GUESS. Simulations show a strong positive trend in
The recently developed Matched Phase Reassignment (MPR) gives a time-frequency local measure of phase difference between short oscillatory transient signals. However, the resulting phase estimate is not satisfactory as it has poor resolution for high oscillatory frequencies. The MPR is also sensitive to high noise levels and is computationally cumbersome. In this paper, a novel reassignment method
Recent advances in simultaneous estimation of both receiver and sender positions in ad-hoc sensor networks have made it possible to automatically calibrate node positions - a prerequisite for many applications. In man-made environments there are often large planar reflective surfaces that give significant reverberations. In this paper, we study geometric problems of receiver-sender node calibratio
This paper presents the Reassignment Vector Phase Difference Estimator (RVPDE), which gives noise robust relative phase estimates of oscillating transient signals in high noise levels. Estimation of relative phase information between signals is of interest for direction of arrival estimation, source separation and spatio-temporal decoding in neurology as well as for soundscape analysis. The RVPDE
An important issue in simultaneous localisation and mapping is how to match and merge individual local maps into one global map. This is addressed within the field of robotics and is crucial for multi-robot SLAM. There are a number of different ways to solve this task depending on the representation of the map. To take advantage of matching and merging methods that allow for deformations of the lo
Dickcissel (Spiza americana) males occupying territories in cropland sites produced songs that were less similar on average to other Dickcissel songs in their neighborhood than did Dickcissels living in grasslands, where conformity to the local vocal culture was higher. Further, Dickcissel vocal culture changed more quickly over time in cropland sites relative to grassland sites. These differences
