Filtyp
We study variational shrinkage in the sparse normal means model and compare it with the corresponding exact Bayes shrinkage rule. The focus is on the excess quadratic risk of the variational posterior mean. Using a squared-loss decomposition, we show that this excess risk is bounded by the discrepancy between the variational and exact Bayes estimators together with the benchmark Bayes risk. This y
Beamstopper-Integrated Sensors (BIS) based on silicon carbide (SiC) represent a novel class of compact, radiation hard devices that combine beam interception with real-time diagnostics. We present the first characterization of four-quadrant BIS designed for simultaneous intensity and position monitoring on synchrotron beamlines. Based on the established reliability of single-pixel BIS as intensity
Although stellar bars are prevalent in local galaxies, unbarred galaxies constitute a significant fraction, particularly at high redshifts. While some galaxies are unbarred by nature due to stability against the bar instability, several mechanisms capable of transforming barred galaxies into unbarred systems have also been proposed, such as central mass concentration, specific dark matter halo mor
The stellar-mass–halo-mass (SMHM) relation is central to our understanding of galaxy formation and the nature of dark matter. However, its normalization, slope, and scatter are highly uncertain at dwarf galaxy scales. In this paper, we present DarkLight, a new semi-empirical dwarf galaxy formation model designed to robustly predict the SMHM relation for the smallest galaxies. DarkLight harnesses a
This licentiate thesis is based on two papers related to convergence analysis of numerical schemes that contain stochasticity for problems under low-regularity assumptions. The first paper is about a randomized Runge-Kutta scheme for stiff ODEs. The second paper is on a domain decomposition method for parabolic SPDEs.In the first paper, we show that a two-stage singly diagonally implicit Runge-Kut
Magnetic fields are a key factor in the evolution of planets and their atmospheres, but they are still poorly constrained for exoplanets owing to limited direct observations. Ultra-hot Jupiters provide a new avenue to probe magnetic effects, as the circulation of their highly ionized atmospheres could be directly sensitive to the atmospheric magnetic field. However, it remains unclear whether the
The main goal of this compilation thesis has been to investigate the conformational ensemble of the intrinsically disordered protein (IDP) histatin 5 by using a mixture of experimental and computational techniques including, but not limited to, small-angle X-ray scattering (SAXS), circular dichroism (CD) spectroscopy, atomistic molecular dynamics (MD) simulations, and coarse-grained Monte Carlo (M
Protein–protein interactions are crucial in biology and play roles in for example, the immune system, signaling pathways, and enzyme regulation. Ultra-high affinity interactions (Kd <0.1 nM) occur in these systems, however, structures and energetics behind stability of ultra-high affinity protein–protein complexes are not well understood. Regulation of the starch debranching barley limit dextrinas
Jet substructure has provided new opportunities for searches and measurements at the LHC, and has seen continuous development since the optimization of the large-radius jet definition used by ATLAS was performed during Run 1. A range of new inputs to jet reconstruction, pile-up mitigation techniques and jet grooming algorithms motivate an optimisation of large-radius jet reconstruction for ATLAS.
A search for heavy resonances decaying into a pair of Z bosons leading to ℓ+ℓ-ℓ′ +ℓ′ - and ℓ+ℓ-νν¯ final states, where ℓ stands for either an electron or a muon, is presented. The search uses proton–proton collision data at a centre-of-mass energy of 13 TeV collected from 2015 to 2018 that corresponds to the integrated luminosity of 139 fb - 1 recorded by the ATLAS detector during Run 2 of the Lar
Low impact falls to the side are the main cause of hip fractures in elderly. Finite element (FE) models of the proximal femur may help in the assessment of patients at high risk for a hip fracture. However, extensive validation is essential before these models can be used in a clinical setting. This study aims to use strain measurements from bilateral digital image correlation to validate an FE mo
A measurement of the Bs0→J/ψϕ decay parameters using 80.5fb-1 of integrated luminosity collected with the ATLAS detector from 13 Te proton–proton collisions at the LHC is presented. The measured parameters include the CP-violating phase ϕs, the width difference Δ Γ s between the Bs0 meson mass eigenstates and the average decay width Γ s. The values measured for the physical parameters are combined
The results of a search for direct pair production of top squarks and for dark matter in events with two opposite-charge leptons (electrons or muons), jets and missing transverse momentum are reported, using 139 fb−1 of integrated luminosity from proton-proton collisions at s = 13 TeV, collected by the ATLAS detector at the Large Hadron Collider during Run 2 (2015–2018). This search considers the
We explore interactions between equally charged surfaces in the presence of simple salt and either neutral or monovalently charged polyampholytes. We consider the possibility of using these charged polymers as crude models of ion clusters. The latter have been hypothesized to form in concentrated aqueous salt solutions and are possibly related to anomalous underscreening. This phenomenon usually m
The Haro 11 galaxy merger is the closest known Lyman continuum (LyC) leaker and a strong Lyman-α (Lyα) emitter, making it an important analogue of the high-z galaxies that reionised the early Universe. To investigate how Haro 11’s properties arise, we perform a radiation hydrodynamics simulation of the merger, and create mock observations of LyC, Lyα, and Hα, from which we compute their luminositi
Ion clustering has been proposed as a mechanism leading to the peculiar "anomalous underscreening" phenomenon seen for electrostatic interactions between charged surfaces immersed in concentrated electrolytes. These interactions have been measured using the Surface Force Apparatus, according to which there are strong repulsive interactions between like-charged surfaces, with a range that increases
Working with pushbroom imagery in photogrammetry and remote sensing presents a fundamental challenge in object-to-image space transformation. For this transformation, accurate estimation of Exterior Orientation Parameters (EOPs) for each scanline is required. To tackle this challenge, Best Scanline Search or Determination (BSS/BSD) methods have been developed. However, the current BSS/BSD methods
The ALICE Collaboration reports measurements of the semi-inclusive distribution of charged-particle jets recoiling from a high transverse momentum (high pT) charged hadron, in pp and central Pb-Pb collisions at center-of-mass energy per nucleon-nucleon collision sNN=5.02 TeV. The large uncorrelated background in central Pb-Pb collisions is corrected using a data-driven statistical approach which e
We have compared the performance of 64 different computational methods, based on combined quantum mechanical (QM) and molecular mechanical (QM/MM) or QM-cluster calculations in a continuum solvent, to estimate the acid constant (pKa) of metal-bound ligands in proteins. As a calibration set, we use 12 experimental pKa values from six different proteins that involve Zn2+, Fe3+, or Fe4+. We employ tw
