Filtyp
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been sh
We study how close-in systems such as those detected by Kepler are affected by the dynamics of bodies in the outer system. We consider two scenarios: outer systems of giant planets potentially unstable to planet-planet scattering and wide binaries that may be capable of driving Kozai or other secular variations of outer planets' eccentricities. Dynamical excitation of planets in the outer system r
A pre-existing algebraic graphic statics method is extended to allow for interactive manipulations of the force diagram, from which an updated form diagram is determined. Newton's method is used to solve a set of non-linear equations, and the required Jacobian matrix is derived. Additional geometric constraints on the form diagram are introduced, and methods for improving the robustness of the met
We have studied the binding of 102 ligands to the farnesoid X receptor within the D3R Grand Challenge 2016 blind-prediction competition. First, we employed docking with five different docking software and scoring functions. The selected docked poses gave an average root-mean-squared deviation of 4.2 Å. Consensus scoring gave decent results with a Kendall’s τ of 0.26 ± 0.06 and a Spearman’s ρ of 0.
Impact of decisions in the design process is initially high and declines as the design matures. However, few computational tools are available for the early design phase, thus an opportunity exists to create such tools. New technology opens up new possibilities to create new and novel computational tools. In this work an existing application is adapted for a new novel 3D input device that is named
This paper presents a study exploring the capabilities of a new method, described by Åkesson and Alic [1], which extends the capabilities of the algebraic graphic statics method, by Van Mele and Block [11]. The new method extends the algebraic graphic statics method by making it bi-directional i.e. allowing for determination of an updated form diagram by making direct interactive manipulations of
Bubbles in DNA are involved in many important biological processes. In this work, a coarse-grained model is used for characterizing bubbles formed in DNA melting. The model resorts only to electrostatic interactions at the Debye-Hückel level, in combination with a short-ranged attractive interaction within a base pair. In spite of also omitting atomistic details, the model is able to capture exper
The partial reinforcement extinction effect (PREE) is an experimentally established phenomenon: behavioural response to a given stimulus is more persistent when previously inconsistently rewarded than when consistently rewarded. This phenomenon is, however, controversial in animal/human learning theory. Contradictory findings exist regarding when the PREE occurs. One body of research has found a w
This paper considers the role of digital recording methods and visualisation tools in the primary recording of archaeology at the Neolithic tell site of Çatalhöyük, Turkey. Operating within and building on Çatalhöyük Research Project's understanding of reflexive methods (Hodder 2000b, 2003; Berggren and Nilson 2014; Berggren et al. 2015) we incorporate elements of science and technology studies (P
Vibrations in a built environment can exceed the requirements for sensitive equipment in a building or can cause annoyance to residents. Hence, there is often a need for reducing such vibrations. The vibrations can originate from ambient sources such as motorway traffic, or from internal sources such as people walking inside the building. Disturbing vibrations can be reduced by reduction measures.
A method for form finding with dynamic relaxation and Non-Uniform Rational B-Splines (NURBS) based isogeometric membrane elements has been implemented and studied regarding the influence of the discretization and element shape on the form finding. The procedure allows for rapid form finding since NURBS describe the curved geometry well and it is shown that the form-finding can be performed using a
Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings geometry, massing, and overall form are usually made during the first phase. Considering structural performance requirements during conceptual design enhances interdisciplinary interac
