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Cyclin E is one of the key regulators of the G(1)/S transition in the cell cycle. Overexpression of cyclin E has been observed in several malignancies and is associated with high proliferation, aberrant expression of other cell cycle regulators and chromosomal instability in vitro. To explore potential associations between cyclin E deregulation and inactivation of the p53 tumor suppressor gene in
We analyze public-policy speeches in the Florentine Consulte e Pratiche, immediately prior to the Ciompi Revolt, for signs of elite factional conflict, in the context of self-proclaimed unity. We employ three statistical analyses of these speeches in Latin: namely, scatterplots of word frequencies, Wordfish scaling, and regressions on speech-similarities. Plus we employ two qualitative analyses: a
New methodologies based on supercritical fluid extraction (SFE) have been developed for the determination of fat-soluble vitamins in processed foods. The results obtained so far indicate that SFE is well suited to extraction of fat-soluble vitamins from food products, although validation work is required to establish accuracy and precision. The vitamins investigated were A, E and beta-carotene, an
This paper presents a search for the t-channel exchange of an R-parity violating scalar top quark ((t) over tilde) in the e(+/-)mu(-/+) continuum using 2.1 fb(-1) of data collected by the ATLAS detector in root s = 7 TeV pp collisions at the Large Hadron Collider. Data are found to be consistent with the expectation from the Standard Model backgrounds. Limits on R-parity-violating couplings at 95
Increasing impacts from hazards worldwide, including Sweden, have prompted international efforts to promote the development of national strategies for disaster risk reduction (DRR) and resilience to reduce associated impacts and support sustainable development. The development of such strategies is global target E of the Sendai Framework for DRR 2015-2030, which was adopted in 2015 by Sweden and o
Previous epidemiological studies suggest an inverse association between allergies, marked by elevated immunoglobulin (Ig) E levels, and non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent and prospective data are sparse. We examined the association between prediagnostic total (low: <20; intermediate: 20-100; high >100 kU/l) and specific IgE (negative: <0.35; positive ≥0.35 kU/I
BACKGROUND: A previous study has shown that pentoxifylline in combination with vitamin E can reverse radiation-induced fibrosis. The aim of the present study is to investigate if the same drugs could prevent radiation-induced side-effects in women with breast cancer. PATIENTS AND METHODS: A randomised, placebo-controlled, double-blind, parallel group trial was performed. Women with breast cancer w
The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence
The loop region of chymotrypsin inhibitor 2 from barley has been employed as a scaffold for testing the intrinsic propensity of a peptide fragment to form a secondary structure. The helix formation of the nine amino acid residue segment Lys-Gln- Ala-Val- Asp- Asn- Ala-Tyr-Ala of helix E from subtilisin Carlsberg has been studied by the construction of a hybrid consisting of chymotrypsin inhibitor
The inclusive top quark pair (t (t) over tilde) production cross-section sigma(t (t) over bar) has been measured in proton-proton collisions at root s = 7 TeV and root s = 8 TeV with the ATLAS experiment at the LHC, using t (t) over bar events with an opposite-charge e mu pair in the final state. The measurement was performed with the 2011 7 TeV dataset corresponding to an integrated luminosity of
The production cross sections of the inclusive Drell-Yan processes W-+/- -> l nu and Z/gamma* -> ll (l = e, mu) are measured in proton-proton collisions at root s = 7 TeV with the ATLAS detector. The cross sections are reported integrated over a fiducial kinematic range, extrapolated to the full range, and also evaluated differentially as a function of the W decay lepton pseudorapidity and the Z b
Sedan den första januari 2013 gäller nya avdragsbegränsningsregler för aktiebolag för koncerninterna räntor inom svensk skatterätt. Som huvudregel nekas avdrag för räntor som löper på alla typer av skulder till ett annat bolag inom koncernen. Ett av undantagen till begränsningen är fall där skuldförhållandet är affärsmässigt motiverat enligt den så kallade ventilen. Ventilen fick under lagens föSince the first of January 2013 the new interest deduction legislation on inter corporate loans has taken effect in Swedish tax law. In general, deduction of interest on inter corporate loans are from now on denied regardless what the loan is used to. As an exception interests on loans justified mainly by business reasons will still be granted deduction. This exception is called the valve (Swedish
Background and purpose - Vitamin E infused highly cross-linked polyethylene (VEPE) was introduced in order to enhance oxidative resistance in highly cross-linked polyethylene cups in total hip arthroplasty (THA). We have, with a follow-up of 5 years, evaluated wear characteristics of 2 identically designed cemented cups with the only difference being the material, VEPE or ultra-high molecular weig
In an attempt to identify subtypes of breast cancer and pinpoint patterns of cell cycle regulatory defects associated with clinical behaviour, proliferation and other transformation associated events, a multitude of cell cycle regulatory proteins were analysed in a material of 113 primary breast cancers. Increased proliferation was observed in two different scenarios; (1) with high cyclin D1 and e
Nos últimos anos, houve uma repressão contra defensores do meio ambiente em Uganda. Jornalistas, estudantes, agricultores e moradores da zona rural defendem o ambiente natural, protestando e mobilizando-se contra o tratamento injusto e a migração forçada causada por infraestruturas de combustíveis fósseis, agronegócio, energia hidrelétrica ou compensação de carbono. Essa situação colocou as autori
BACKGROUND: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.OBJECTIVE: We investigated the relation between dietary vitamin K(1) intake, APOE polymorphisms, and markers of bone health.DESIGN: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) in a cohort of Scottish wome
