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In the conceptual design phase, solutions are reached through an iterative, high-paced and often chaotic manner. Conventional advanced structural analysis software is often too advanced and insufficiently agile to follow this high-paced work pattern. Premature use of advanced structural analysis tools can negatively affect conceptual understanding and the quality of the conceptual design. The mult

Lytic polysaccharide monooxygenases (LPMOs) are copper enzymes that boost the degradation of different polysaccharides and play important roles in the sustainable production of biofuels, in human and plant pathogens, and potentially also in plastic degradation. Their activity depends on a co-substrate, where recent results show that hydrogen peroxide is the preferred co-substrate. Under typical ex

Globular clusters (GCs) are among the oldest and densest stellar systems in the Universe, yet how they form remains a mystery1. Here we present a suite of cosmological simulations in which both dark-matter-free GCs and dark-matter-rich dwarf galaxies naturally emerge in the Standard Cosmology. We show that these objects inhabit distinct locations in the size–luminosity plane and that they have sim

Joining Nic and Rebecca in this first episode of the third season of The Meridian is none other than NASA astronaut Jim Pawelczyk, professor at Penn State University in Kinesiology and Physiology, who looks into how the human body adapts when in space.In this third season we are also including some Cosmic Curiosities. These are some ideas, events or trivia from astronomic history that Ross, Victor

We introduce a novel unsteady shear protocol, which we name rotary shear (RS), where the flow and vorticity directions are continuously rotated around the velocity-gradient direction by imposing two out-of-phase oscillatory shears (OSs) in orthogonal directions. We perform numerical simulations of dense suspensions of rigid non-Brownian spherical particles at volume fractions between 0.40 and 0.55

Combined quantum mechanics and molecular mechanics (QM/MM) calculations are a popular approach to study reaction mechanisms of enzymes. However, recently, the reproducibility of such calculations has been questioned, comparing the results of two software: NWChem and Q-Chem. Here, we continue and extend this study by including three additional software─ComQum, ORCA, and AMBER─using the same test ca

Context. According to the well-established hierarchical framework for galaxy evolution, galaxies grow through mergers with other galaxies. The ΛCDM cosmological model predicts that the stellar halos of massive galaxies are rich in remnants resulting from minor mergers. Stellar Streams Legacy Survey (SSLS) has provided a first release of a catalogue with a statistically significant sample of stella

New extragalactic measurements of the cloud population-averaged star formation efficiency per free-fall time, Ïμff, from PHANGS show little sign of a theoretically predicted dependence on the gas virial level and weak variation with cloud-scale gas velocity dispersion. We explore ways to bring theory into consistency with the observations, particularly by highlighting systematic variations in inte

In order to understand and manipulate biological function at the molecular level, access to high-resolution structures of biological macromolecules is essential, as structure is intimately linked to function. The two main experimental techniques that can achieve atomic, or near-atomic, resolution are crystallography and electron microscopy. Unfortunately, the experimental data alone is typically n

Dust is essential to the evolution of galaxies and drives the formation of planetary systems. The challenge of inferring the origin of different pre-solar dust grains from meteoritic samples motivates forward modelling to understand the contributions of low- and high-mass stars to dust in our Solar system. In this work we follow the evolution of dust with tracer particles within a hydrodynamical s

We investigate the young stellar cluster population of M51 and how it is affected by encounters with giant molecular clouds (GMCs). We combine a galactic model with N-body simulations of 5000 unique clusters in the mass range [600-24000] M⊙. We simulate each cluster twice: with (CR) and without (CN) tidal perturbations from the GMCs. We are able to reproduce the majority of the observed mass- and

It is an open question whether small planets around M dwarfs are able to maintain atmospheres. The Hot Rocks Survey aims to address this question by observing nine rocky exoplanets orbiting M dwarfs with MIRI emission photometry to constrain the onset of atmospheres. In this paper, we present two MIRI F1500W (15 μm) eclipses of LTT 3780 b, an ultrashort-period super-Earth (P = 0.768 days, R = 1.32

Current star formation models are based on the structure of the interstellar medium (ISM), yet the details on how local physics propagates to galactic-scale properties are still debated. To investigate this, we use VINTERGATAN, a high-resolution cosmological zoom-in simulation of a Milky Way-like galaxy. We study how the velocity dispersion and density structure of the cold neutral ISM on 50–100 p