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Cathepsin E (CTSE), an aspartic proteinase, is differentially expressed in the metaplasia-dysplasia-neoplasia sequence of gastric and colon cancer. We evaluated CTSE in Barrett's esophagus (BE) and cancer because increased CTSE levels are linked to improved survival in several cancers, and other cathepsins are up-regulated in BE and esophageal adenocarcinoma (EAC). A total of 273 pretreatment tiss

Author: Amanda Petersson Title: “Hi I’m kind of depressed” - An Ethnographic Study of Adolescents’ Interaction Concerning Mental Illness on the Internet [Translated title] Supervisor: Gabriella Scaramuzzino Assessor: Torbjörn Hjort The aim of this study has been to examine how adolescents interact concerning mental illness on the Internet. I have spent time on one of the largest Internet forums t

Inappropriate surface expression of voltage-gated Ca(2+)channels (CaV) in pancreatic ß-cells may contribute to the development of type 2 diabetes. First, failure to increase intracellular Ca(2+) concentrations at the sites of exocytosis impedes insulin release. Furthermore, excessive Ca(2+) influx may trigger cytotoxic effects. The regulation of surface expression of CaV channels in the pancreatic

Winner of the 1938 Littoriali della Cultura e dell’Arte, the project for a Hotel-Refuge in Valmalenco (2000 m altitude) by Gianni Albricci (1916-2001) and Marco Zanuso (1916-2001) was conceived by two young students from the Faculty of Architecture at the Politecnico di Milano. The skillful design combines traditional alpine materials with innovative solutions, reflecting the autarkic policies of

Shared electric scooters (e-scooters) are widely promoted as a low-carbon urban transport solution. However, their environmental impact depends on lifespan, operations, and modal shift. This study evaluates life cycle greenhouse gas emissions of shared e-scooters operating in Dubai, UAE. A cradle-to-grave life cycle assessment is conducted, considering manufacturing, transportation, use phase elec

Endometrial prostaglandins (PGs) and the PGE2/PGF2alpha ratio play an important role in regulating the estrous cycle and establishment of pregnancy. The enzymes downstream of cyclooxygenase-2 may determine the PGE2/PGF2alpha ratio in the porcine uterus. Thus, we have cloned porcine PGF synthase (PGFS) and microsomal PGE synthase-1 (mPGES-1) and characterized their expression in porcine endometrium

Activation of receptor tyrosine kinases needs tight control by tyrosine phosphatases to keep their normal function. In this study, we investigated the regulation of activation of the type III receptor tyrosine kinase KIT by protein tyrosine phosphatase receptor type E (PTPRE). We found that PTPRE can associate with wild-type KIT and inhibit KIT activation in a dose-dependent manner, although the a

We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.

Moving from some Italian case law the article analyses several aspect linked to the transfers of undertaking such as its legal notion (and its differences between the transfers of a plurality of goods), the right to raise a legal claim following the Italian civil procedure and the consequences of the violation of the information duty of the trade unions.

This paper analysis sexual scripts theory in relation to gay men courtship, love relationships, and casual sex. The aim is to understand how gay masculinity is evolving in the 21st Century. Previous research has reinforced the concept that gay men follow heterosexual masculinity and scripts in their relationships with other men. Here, analysing data from the most used gay dating app ‘Grindr’, we t