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Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. ApoE in the brain is mainly generated by astrocytes, however, neurons can also produce ApoE under stres

Context. 55 Cnc e is a transiting super-Earth (radius 1.88 R⊕ and mass 8 M⊕) orbiting a G8V host star on a 17-h orbit. Spitzer observations of the planet's phase curve at 4.5 μm revealed a time-varying occultation depth, and MOST optical observations are consistent with a time-varying phase curve amplitude and phase offset of maximum light. Both broadband and high-resolution spectroscopic analyses

In this paper, we assess the relationship between the environmental pillar score (the ‘E’ in ESG) and stock returns in the Swedish stock market. Specifically, we analyze the OMXS60 index, which comprises the 60 most traded assets on the Nasdaq OMX Stockholm Exchange, examining how environmental ratings correlates with the development of returns. Additionally, we investigate how this relationship i

The botulinum neurotoxins are potent molecules that are not only responsible for the lethal paralytic disease botulism, but have also been harnessed for therapeutic uses in the treatment of an increasing number of chronic neurological and neuromuscular disorders, in addition to cosmetic applications. The toxins act at the cholinergic nerve terminals thanks to an efficient and specific mechanism of

The paper’s title evokes a conversation; in fact it has been constructed like a joint revisitation of Bianca Beccalli’s forty years work on labour, gender, and politics, reconsidering old challenges and facing emergent ones. The paper deals with two levels of analysis: a historical and sociological interpretation of social movements, work, and politics on the one side, while dealing on the other s

Monte Carlo models of DIS e-gamma scattering must describe hard emissions as well as the soft and collinear limits. Comparison with the observed experimental hadronic energy flow has shown that various models underestimate the high-p_T contribution, in particular at low-x. We have attempted to tune the Herwig, Pythia and Ariadne models to improve the agreement with the data, and to understand the

Abstract in ItalianNel 2017 Dennis C. Rasmussen ha pubblicato The Infidel and the Professor: David Hume, Adam Smith, and the Friend-ship that Shaped Modern Thought (Princeton-Oxford, Princeton University Press). Si tratta di uno studio destinato a suscitare un vivace dibattito sia per quel che concerne la re-visione dell’immagine canonica dei due filosofi, sia per le implicazioni teoriche ad essa

Per oltre quarant’anni, la scrittura della storia nei paesi dell’Europa orientaleè stata fortemente condizionata dagli imperativi ideologici e propagandisticidei regimi comunisti. La storia, più di ogni altra disciplina umanistica, offrivagiustifi cazioni, e quindi legittimità, al potere. Indagare il rapporto tra storia epotere in questo ambito signifi ca tanto addentrarsi nella storia dei sociali

The thesis, moving from several critical points of the Italian industrial relation system, studies in which way the rules that regulate those systems can influence the competitiveness of the enterprises. For this scope are compared several European experiences such as the Italian, Spanish and French ones, with particular attention to the changes that have been put in place after the 2008 economic