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Apolipoprotein E (APOE) is a lipid-transport protein that functions as a key mediator of lipid transport and cholesterol metabolism. Recent studies have shown that peptides derived from human APOE display anti-inflammatory and antimicrobial effects. Here, we applied in vitro assays and fluorescent microscopy to investigate the anti-bacterial effects of full-length APOE. The interaction of APOE wit
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Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A
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In this article I conceptualise BDSM (Bondage, Domination and Submission, Discipline, Sadism and Masochism) practices within the frame of contemporary intimacies. This article draws from an empirical research in Milan, involving qualitative interviews and participant observations. Initially, I present a definition of BDSM drawn from contemporary sociological and anthropological literature. Then, I
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Las soluciones basadas en la naturaleza tienen el potencial de ofrecer múltiples ventajas de cara a diversos retos de sostenibilidad a los que se enfrentan las ciudades. Pueden ayudar a limitar el impacto del cambio climático, expandir la biodiversidad y mejorar la calidad medioambiental, así como contribuir a las actividades económicas y el bienestar social. Siga leyendo para descubrir en qué con
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The year was 2012 and we had just started the School of Industrial Design at the Faculty of engineering in Lund and we had no or little idea of what we were to experience. Three years have now passed by and we feel more enlightened than ever before. What we feel is a place where the learning technique has not just given us skills to become great designers, but also made us aware of how to embrace