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Miljögifter: konsekvenser och riskhantering

Kemikalier släpps i allt snabbare takt ut i vår omgivning, i luft, mark och vatten. Detta kan få allvarliga konsekvenser för människor, djurliv och hela ekosystem. Ändå vet vi fortfarande väldigt lite om de processer som orsakar toxicitet och genererar negativa effekter, och hur akuta och kroniska effekter uppstår i olika arter. De begränsade kunskaperna gällande att korrekt bedöma risker med kemi

https://www.cec.lu.se/sv/forskning/forskningsteman/miljogifter-konsekvenser-och-riskhantering - 2026-08-23

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Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematotoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recommended that these patients should not receive AZA or 6-MP treatment for inflammatory bowel disease. W

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Objective: We investigated whether newborns respond differently to novel and deviant sounds during quiet sleep. Methods: Twelve healthy neonates were presented with a three-stimulus oddball paradigm, consisting of frequent standard (76%), infrequent deviant (12%), and infrequent novel stimuli (12%). The standards and deviants were counterbalanced between the newborns and consisted of 500 and 750 H

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1. The ability to resist infection is an important component of survival and lifetime reproductive success. Mounting and maintaining an immunological defence is assumed to be energetically costly and nutritional resources expended on immune function may induce trade-offs with other energetically expensive functions, including reproduction. Resource limitation may even have transgenerational effect

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Objective: To investigate if administration of CNI-1493, an inhibitor of the synthesis of proinflammatory cytokines and NO, protects against development of joint destruction in collagen induced arthritis ( CIA) in rats. Methods: In a placebo controlled experiment, CNI-1493 was given once daily intraperitoneally after onset of clinical arthritis in DA rats. Disease progression was studied by clinic

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Prognostic factors and treatment results were analysed in 72 consecutive patients with primary gastric lymphoma treated between 1970 and 1985. There were 37 patients in stage IE, 17 in IIE, 3 in IIES and 15 in stage IV. Histopathological re-evaluation and classification according to the TNM system were performed. We found that disseminated disease (stage IV), serosal penetration (T3), involvement